Search Results - "elSohly, M"

Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPARγ and SUR agonists by Ibrahim, Mohammed K., Eissa, Ibrahim H., Abdallah, Abdallah E., Metwaly, Ahmed M., Radwan, M.M., ElSohly, M.A.

“…[Display omitted] •Eighteen compounds of novel quinoxaline derivatives were designed and synthesized.•Molecular docking and pharmacophore studies were carried…”
Get full text

Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors by Ibrahim, M.K., Taghour, M.S., Metwaly, A.M., Belal, A., Mehany, A.B.M., Elhendawy, M.A., Radwan, M.M., Yassin, A.M., El-Deeb, N.M., Hafez, E.E., ElSohly, M.A., Eissa, I.H.

“…New series of [1,2,4]triazolo [4,3-a]quinoxaline and bis([1,2,4]triazolo)[4,3-a:3′,4′-c]quinoxaline derivatives have been designed, synthesized and…”
Get full text

Liquid Chromatography-Tandem Mass Spectrometry Analysis of Urine Specimens for K2 (JWH-018) Metabolites by ElSohly, Mahmoud A., Gul, Waseem, ElSohly, Kareem M., Murphy, Timothy P., Madgula, Vamsi L.M., Khan, Shabana I.

“…Marijuana is the most widely used drug of abuse all over the world. The major active constituent of the drug is Δ9-tetrahydrocannabinol (Δ9-THC). Δ9-THC exerts…”
Get full text

Exposing the molecular heterogeneity of glycosylated biotherapeutics by Schachner, Luis F., Mullen, Christopher, Phung, Wilson, Hinkle, Joshua D., Beardsley, Michelle Irwin, Bentley, Tracy, Day, Peter, Tsai, Christina, Sukumaran, Siddharth, Baginski, Tomasz, DiCara, Danielle, Agard, Nicholas J., Masureel, Matthieu, Gober, Joshua, ElSohly, Adel M., Melani, Rafael, Syka, John E. P., Huguet, Romain, Marty, Michael T., Sandoval, Wendy

“…The heterogeneity inherent in today’s biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule’s safety and efficacy…”
Get full text

Synthetic approaches to oligomeric natural products by Snyder, Scott A, ElSohly, Adel M, Kontes, Ferenc

Get more information

Photoactivated Bioconjugation Between ortho-Azidophenols and Anilines: A Facile Approach to Biomolecular Photopatterning by El Muslemany, Kareem M, Twite, Amy A, ElSohly, Adel M, Obermeyer, Allie C, Mathies, Richard A, Francis, Matthew B

“…Methods for the surface patterning of small molecules and biomolecules can yield useful platforms for drug screening, synthetic biology applications,…”
Get full text

Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids by Ilan, A. B, Gevins, A, Coleman, M, ElSohly, M. A, de Wit, H

“…This study investigated the contribution of different cannabinoids to the subjective, behavioral and neurophysiological effects of smoked marijuana. Healthy…”
Get full text

Synthetic and Theoretical Investigations of Myrmicarin Biosynthesis by Snyder, Scott A, ElSohly, Adel M, Kontes, Ferenc

“…Off to a good start: Use of a carefully designed building block coupled with several highly selective reactions has enabled the syntheses of the monomeric…”
Get full text

Comparison of the subjective effects of Delta(9)-tetrahydrocannabinol and marijuana in humans by Wachtel, S R, ElSohly, M A, Ross, S A, Ambre, J, de Wit, H

“…There has been controversy about whether the subjective, behavioral or therapeutic effects of whole plant marijuana differ from the effects of its primary…”
Get full text

Pelargonium Oil and Methyl Hexaneamine (MHA): Analytical Approaches Supporting the Absence of MHA in Authenticated Pelargonium graveolens Plant Material and Oil by ElSohly, Mahmoud A., Gul, Waseem, ElSohly, Kareem M., Murphy, Timothy P., Weerasooriya, Aroona, Chittiboyina, Amar G., Avula, Bharathi, Khan, Ikhlas, Eichner, Amy, Bowers, Larry D

“…Methylhexaneamine (MHA) has been marketed in dietary supplements based on arguments that it is a constituent of geranium (Pelargonium graveolens) leaves,…”
Get full text

Prevalence of Drugs Used in Cases of Alleged Sexual Assault by ElSohly, M.A., Salamone, S.J.

“…In recent years, there has been an increase in the number of reports in the U.S. of the use of drugs, often in conjunction with alcohol, to commit sexual…”
Get full text

Development of Oxidative Coupling Strategies for Site-Selective Protein Modification by ElSohly, Adel M, Francis, Matthew B

“…As the need to prepare ever more complex but well-defined materials has increased, a similar need for reliable synthetic strategies to access them has arisen…”
Get full text

Mechanistic Investigations of the Cyclocondensation Step of the Knorr Pyrrole Synthesis by A. Snyder, Scott, Kontes, Ferenc, M. ElSohly, Adel

Get full text

LC-MS-(TOF) Analysis Method for Benzodiazepines in Urine Samples from Alleged Drug-Facilitated Sexual Assault Victims by ElSohly, Mahmoud A., Gul, Waseem, ElSohly, Kareem M., Avula, Bharathi, Khan, Ikhlas A.

“…In recent years there has been an increase in the number of reports in the U.S. of the use of drugs to commit sexual assault. In 1994, a nationwide urine…”
Get full text

In vitro germplasm conservation of elite Stevia rebaudiana Bertoni by Lata, H, Chandra, S, Wang, Y. H, ElSohly, M. A, Khan, I. A

“…Germplasm conservation of elite Stevia rebaudiana Bert. was attempted by using synthetic seed technology and medium with added osmotic agents. Explants of…”
Get full text

LC-MS-MS Analysis of N, -Diethylphenethylamine (N, -ETH) and Its Positional Isomer N, -Diethylphenethylamine (N, -ETH) in Dietary Supplements by ElSohly, M. A., Murphy, T. P., ElSohly, K. M., Gul, W.

Get full text

Enzymatic Modification of N‑Terminal Proline Residues Using Phenol Derivatives by Maza, Johnathan C, Bader, Daniel L. V, Xiao, Lifeng, Marmelstein, Alan M, Brauer, Daniel D, ElSohly, Adel M, Smith, Matthew J, Krska, Shane W, Parish, Craig A, Francis, Matthew B

“…A convenient enzymatic strategy is reported for the modification of proline residues in the N-terminal positions of proteins. Using a tyrosinase enzyme…”
Get full text

ortho-Methoxyphenols as Convenient Oxidative Bioconjugation Reagents with Application to Site-Selective Heterobifunctional Cross-Linkers by ElSohly, Adel M, MacDonald, James I, Hentzen, Nina B, Aanei, Ioana L, El Muslemany, Kareem M, Francis, Matthew B

“…The synthesis of complex protein-based bioconjugates has been facilitated greatly by recent developments in chemoselective methods for biomolecular…”
Get full text

An Efficient Approach to the Securinega Alkaloids Empowered by Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis by ElSohly, Adel M., Wespe, Daniel A., Poore, Tyler J., Snyder, Scott A.

“…Folding it all together: Most of the syntheses developed for the securinega alkaloid class require lengthy sequences to create their bridging butenolide…”
Get full text

High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry by Shi, Rachel Liuqing, Dillon, Michael A, Compton, Philip D, Sawyer, William S, Thorup, John R, Kwong, Mandy, Chan, Pamela, Chiu, Cecilia P C, Li, Ran, Yadav, Rajbharan, Lee, Genee Y, Gober, Joshua G, Li, Zhiyu, ElSohly, Adel M, Ovacik, Ayse Meric, Koerber, James T, Spiess, Christoph, Josephs, Jonathan L, Tran, John C

“…Intact protein mass spectrometry (MS) coupled with liquid chromatography was applied to characterize the pharmacokinetics and stability profiles of therapeutic…”
Get full text