Search Results - "el Kouni, M H"

Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis by EL KOUNI, M. H, DIOP, D, O'SHEA, P, CARLISLE, R, SOMMADOSSI, J.-P

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Uridine phosphorylase from Schistosoma mansoni by el Kouni, M H, Naguib, F N, Niedzwicki, J G, Iltzsch, M H, Cha, S

“…Uridine phosphorylase is the only pyrimidine nucleoside cleaving activity that can be detected in extracts of Schistosoma mansoni. The enzyme is distinct from…”
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Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate by El Kouni, M.H, Diop, D, Cha, S

“…Schistosoma mansoni, administration of nitrobenzylthioinosine 5'-monophosphate with high doses of tubercidin (lethal doses if injected alone) by…”
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Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii by EL KOUNI, M. H, GUARCELLO, V, AL SAFARJALANI, O. N, NAGUIB, F. N. M

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Antiviral Activity and Intracellular Metabolism of Bis(tButylSATE) Phosphotriester of β-L-2′,3'Dideoxyadenosine, a Potent Inhibitor of HIV and HBV Replication by Placidi, L, Faraj, A, Loi, AG, Pierra, C, Egron, D, Cretton-Scott, E, Gosselin, G, Périgaud, C, Martin, LT, Schinazi, RF, Imbach, JL, el Kouni, MH, Bryant, ML, Sommadossi, JP

“…The β-L-nucleoside analogue β-L-2′,3′-dideoxy adenosine (β-L-ddA) has been shown to exhibit limited antiviral activities. This was attributed to its rapid…”
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Uridine phosphorylase inhibitors: Chemical modification of benzyloxybenzyl-barbituric acid and its effects on UrdPase inhibition by Guerin, David J., Mazeas, Daniel, Musale, Manoj S., Naguib, Fardos N.M., Al Safarjalani, Omar N., el Kouni, Mahmoud H., Panzica, Raymond P.

“…5-( o-Benzyloxy)benzylbarbituric acid ( 6) and 5-( p-benzyloxy)benzylbarbituric acid ( 7) were prepared and their inhibitory activities compared to 5-(…”
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Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy by AL SAFARJALANI, Omar N, ZHOU, Xiao-Jian, NAGUIB, Fardos N. M, GOUDGAON, Naganna M, SCHINAZI, Raymond F, EL KOUNI, Mahmoud H

“…The purpose of this investigation was to evaluate the ability of oral PTAU, 5-(phenylthio)acyclouridine, to increase the concentration of endogenous plasma…”
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Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii by Iltzsch, Max H., Uber, Sheri S., Tankersley, Kevin O., el Kouni, Mahmoud H.

“…One hundred and twenty-eight purine nucleoside analogs were evaluated as ligands of Toxoplasma gondii adenosine kinase (EC 2.7.1.20) by examining their ability…”
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Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from toxoplasma gondii by Javaid, Zahid Z, el Kouni, Mahmoud H, Iltzsch, Max H

“…Sixty-seven pyrimidine nucleobase analogues were evaluated as ligands of Toxoplasma gondii orotate phosphoribosyltransferase (OPRTase, EC 2.4.2.10) by…”
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Effect of the N-glycosidic bond conformation and modifications in the pentose moiety on the binding of nucleoside ligands to uridine phosphorylase by el Kouni, M H, Naguib, F N, Chu, S H, Cha, S M, Ueda, T, Gosselin, G, Imbach, J L, Shealy, Y F, Otter, B A

“…Several arabinosyl-, xylosyl-, lyxosyl, 5'-deoxy-, acyclo-, 2,2'-anhydro-, 2,3'-anhydro-2'-deoxy-, 2,5'-anhydro-, 6,5'-cyclo-, and carbocyclic analogues of…”
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5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase by el Kouni, Mahmoud H, Goudgaon, Naganna M, Rafeeq, Mohammad, Al Safarjalani, Omar N, Schinazi, Raymond F, Naguib, Fardos N.M

“…5-Phenylthioacyclouridine (PTAU or 1-[(2-hydroxyethoxy)methyl]-5-phenylthiouracil) was synthesized as a highly specific and potent inhibitor of uridine…”
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Enzymes of uracil catabolism in normal and neoplastic human tissues by NAGUIB, F. N. M, EL KOUNI, M. H, SUNGMAN CHA

“…Enzymes of the pyrimidine base catabolism, dihydrouracil dehydrogenase (EC 1.3.1.2), dihydropyrimidinase (EC 3.5.2.2), and beta-ureidopropionase (EC 3.5.1.6)…”
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Isolation and Partial Characterization of a 5′-nucleotidase Specific for Orotidine-5′-monophosphate by El Kouni, Mahmoud H., Cha, Sungman

“…A previously unknown 5′-nucleotidase (5′-ribonucleotide phosphohydrolase, EC 3.1.3.5) (5′-Nase) specific for orotidine 5′-monophosphate (OMP) has been…”
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Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri- O-acetyluridine, a prodrug of uridine by Ashour, Osama M, Naguib, Fardos N.M, Panzica, Raymond P, Al Safarjalani, Omar N, el Kouni, Mahmoud H

“…Administration of 200 mg/kg of 5-fluorouracil (FUra) to mice bearing human colon carcinoma DLD-1 xenografts resulted in 100% mortality. Oral administration of…”
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Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity by PLACIDI, L, CRETTON-SCOTT, E, GOSSELIN, G, PIERRA, C, SCHINAZI, R. F, IMBACH, J.-L, EL KOUNI, M. H, SOMMADOSSI, J.-P

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Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase : relevance to chemotherapy by ASHOUR, O. M, AL SAFARJALANI, O. N, NAGUIB, F. N. M, GOUDGAON, N. M, SCHINAZI, R. F, EL KOUNI, M. H

“…The purpose of this investigation was to evaluate the efficacy of oral 5-(phenylselenenyl)-acyclouridine (PSAU) in increasing endogenous plasma uridine…”
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Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii by el Kouni, Mahmoud H., Naguib, Fardos N.M., Panzica, Raymond P., Otter, Brian A., Chu, Shih-Hsi, Gosselin, Gilles, Chu, Chung K., Schinazi, Raymond F., Shealy, Y.Fulmer, Goudgaon, Naganna, Ozerov, Alexander A., Ueda, Tohru, Iltzsch, Max H.

“…One hundred and fifty analogues of uridine, with various modifications to the uracil and pentose moieties, have been tested and compared with uridine with…”
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Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2′-deoxyuridine against murine colon tumor C26–10 by Ashour, Osama M, Naguib, Fardos N.M, Goudgaon, Naganna M, Schinazi, Raymond F, el Kouni, Mahmoud H

“…The effect of co-administration of 5-(phenylselenenyl)acyclouridine (PSAU), a new uridine phosphorylase (UrdPase, EC 2.4.2.3) inhibitor, on the efficacy of…”
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Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2', 3', 5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy by ASHOUR, O. M, NAGUIB, F. N. M, GOUDGAON, N. M, SCHINAZI, R. F, EL KOUNI, M. H

“…The purpose of this investigation was to study the effects of combining oral 5-(phenylselenenyl)acyclouridine (PSAU) with 2',3',5'-tri-O-acetyluridine (TAU) on…”
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The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression by Chiang, C W, Carter, N, Sullivan, Jr, W J, Donald, R G, Roos, D S, Naguib, F N, el Kouni, M H, Ullman, B, Wilson, C M

“…Purine transport into the protozoan parasite Toxoplasma gondii plays an indispensable nutritional function for this pathogen. To facilitate genetic and…”
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