Search Results - "el Bahhaj, Fatima"

Vorinostat–Polymer Conjugate Nanoparticles for Acid-Responsive Delivery and Passive Tumor Targeting by Denis, Iza, el Bahhaj, Fatima, Collette, Floraine, Delatouche, Régis, Gueugnon, Fabien, Pouliquen, Daniel, Pichavant, Loic, Héroguez, Valérie, Grégoire, Marc, Bertrand, Philippe, Blanquart, Christophe

“…In vivo histone deacetylase (HDAC) inhibition by vorinostat under clinically acceptable dosing is limited by its poor pharmacokinetics properties. A new type…”
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Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy by El Bahhaj, Fatima, Denis, Iza, Pichavant, Loic, Delatouche, Régis, Collette, Floraine, Linot, Camille, Pouliquen, Daniel, Grégoire, Marc, Héroguez, Valérie, Blanquart, Christophe, Bertrand, Philippe

“…Fast clearance, metabolism and systemic toxicity are major limits for the clinical use of anti-cancer drugs. Histone deacetylase inhibitors (HDACi) present…”
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Histone deacetylase inhibitor-polymer conjugate nanoparticles for acid-responsive drug delivery by Denis, Iza, el Bahhaj, Fatima, Collette, Floraine, Delatouche, Régis, Gueugnon, Fabien, Pouliquen, Daniel, Pichavant, Loic, Héroguez, Valérie, Grégoire, Marc, Bertrand, Philippe, Blanquart, Christophe

“…We report the synthesis of acid–responsive polymeric nanoparticles (NPs) consisting of a polymer-histone deacetylase inhibitor conjugate. An innovative aspect…”
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Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy by Delatouche, Régis, Denis, Iza, Grinda, Marion, Bahhaj, Fatima El, Baucher, Estelle, Collette, Floraine, Héroguez, Valérie, Grégoire, Marc, Blanquart, Christophe, Bertrand, Philippe

“…The aim of this study was to develop clickable prodrugs bearing a tunable pH responsive linker designed for acidic pH-mediated release of histone deacetylase…”
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Delivery of epidrugs by el Bahhaj, Fatima, Dekker, Frank J., Martinet, Nadine, Bertrand, Philippe

“…•This review covers prodrugs and nanoparticle-based drug delivery of small molecule epigenetic inhibitors.•A brief overview on epigenetic targets having known…”
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Chemistry for oncotheranostic gold nanoparticles by Trouiller, Anne Juliette, Hebié, Seydou, el Bahhaj, Fatima, Napporn, Teko W., Bertrand, Philippe

“…This review presents in a comprehensive ways the chemical methods used to functionalize gold nanoparticles with focus on anti-cancer applications. The review…”
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Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities by El Bahhaj, Fatima, Désiré, Jérôme, Blanquart, Christophe, Martinet, Nadine, Zwick, Vincent, Simões-Pires, Claudia, Cuendet, Muriel, Grégoire, Marc, Bertrand, Philippe

“…An innovative synthesis of psammaplin-like structure is proposed based on original methodologies using superacid, microwaves, and S-ene chemistry. The new…”
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