Search Results - "eLife"

Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3 by Beghini, Francesco, McIver, Lauren J, Blanco-Míguez, Aitor, Dubois, Leonard, Asnicar, Francesco, Maharjan, Sagun, Mailyan, Ana, Manghi, Paolo, Scholz, Matthias, Thomas, Andrew Maltez, Valles-Colomer, Mireia, Weingart, George, Zhang, Yancong, Zolfo, Moreno, Huttenhower, Curtis, Franzosa, Eric A, Segata, Nicola

“…Culture-independent analyses of microbial communities have progressed dramatically in the last decade, particularly due to advances in methods for biological…”
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New tools for automated high-resolution cryo-EM structure determination in RELION-3 by Zivanov, Jasenko, Nakane, Takanori, Forsberg, Björn O, Kimanius, Dari, Hagen, Wim Jh, Lindahl, Erik, Scheres, Sjors Hw

“…Here, we describe the third major release of RELION. CPU-based vector acceleration has been added in addition to GPU support, which provides flexibility in use…”
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Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants by Weisblum, Yiska, Schmidt, Fabian, Zhang, Fengwen, DaSilva, Justin, Poston, Daniel, Lorenzi, Julio Cc, Muecksch, Frauke, Rutkowska, Magdalena, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Luchsinger, Larry, Hillyer, Christopher D, Caskey, Marina, Robbiani, Davide F, Rice, Charles M, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against…”
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SARS-CoV-2 (COVID-19) by the numbers by Bar-On, Yinon M, Flamholz, Avi, Phillips, Rob, Milo, Ron

“…The COVID-19 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a…”
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The MR-Base platform supports systematic causal inference across the human phenome by Hemani, Gibran, Zheng, Jie, Elsworth, Benjamin, Wade, Kaitlin H, Haberland, Valeriia, Baird, Denis, Laurin, Charles, Burgess, Stephen, Bowden, Jack, Langdon, Ryan, Tan, Vanessa Y, Yarmolinsky, James, Shihab, Hashem A, Timpson, Nicholas J, Evans, David M, Relton, Caroline, Martin, Richard M, Davey Smith, George, Gaunt, Tom R, Haycock, Philip C

“…Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian…”
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A connectome and analysis of the adult Drosophila central brain by Scheffer, Louis K, Xu, C Shan, Januszewski, Michal, Lu, Zhiyuan, Takemura, Shin-Ya, Hayworth, Kenneth J, Huang, Gary B, Shinomiya, Kazunori, Maitlin-Shepard, Jeremy, Berg, Stuart, Clements, Jody, Hubbard, Philip M, Katz, William T, Umayam, Lowell, Zhao, Ting, Ackerman, David, Blakely, Tim, Bogovic, John, Dolafi, Tom, Kainmueller, Dagmar, Kawase, Takashi, Khairy, Khaled A, Leavitt, Laramie, Li, Peter H, Lindsey, Larry, Neubarth, Nicole, Olbris, Donald J, Otsuna, Hideo, Trautman, Eric T, Ito, Masayoshi, Bates, Alexander S, Goldammer, Jens, Wolff, Tanya, Svirskas, Robert, Schlegel, Philipp, Neace, Erika, Knecht, Christopher J, Alvarado, Chelsea X, Bailey, Dennis A, Ballinger, Samantha, Borycz, Jolanta A, Canino, Brandon S, Cheatham, Natasha, Cook, Michael, Dreher, Marisa, Duclos, Octave, Eubanks, Bryon, Fairbanks, Kelli, Finley, Samantha, Forknall, Nora, Francis, Audrey, Hopkins, Gary Patrick, Joyce, Emily M, Kim, SungJin, Kirk, Nicole A, Kovalyak, Julie, Lauchie, Shirley A, Lohff, Alanna, Maldonado, Charli, Manley, Emily A, McLin, Sari, Mooney, Caroline, Ndama, Miatta, Ogundeyi, Omotara, Okeoma, Nneoma, Ordish, Christopher, Padilla, Nicholas, Patrick, Christopher M, Paterson, Tyler, Phillips, Elliott E, Phillips, Emily M, Rampally, Neha, Ribeiro, Caitlin, Robertson, Madelaine K, Rymer, Jon Thomson, Ryan, Sean M, Sammons, Megan, Scott, Anne K, Scott, Ashley L, Shinomiya, Aya, Smith, Claire, Smith, Kelsey, Smith, Natalie L, Sobeski, Margaret A, Suleiman, Alia, Swift, Jackie, Takemura, Satoko, Talebi, Iris, Tarnogorska, Dorota, Tenshaw, Emily, Tokhi, Temour, Walsh, John J, Yang, Tansy, Horne, Jane Anne, Li, Feng, Parekh, Ruchi, Rivlin, Patricia K, Jayaraman, Vivek, Costa, Marta, Jefferis, Gregory Sxe

“…The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain…”
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The Human Cell Atlas by Regev, Aviv, Teichmann, Sarah A, Lander, Eric S, Amit, Ido, Benoist, Christophe, Birney, Ewan, Bodenmiller, Bernd, Campbell, Peter, Carninci, Piero, Clatworthy, Menna, Clevers, Hans, Deplancke, Bart, Dunham, Ian, Eberwine, James, Eils, Roland, Enard, Wolfgang, Farmer, Andrew, Fugger, Lars, Göttgens, Berthold, Hacohen, Nir, Haniffa, Muzlifah, Hemberg, Martin, Kim, Seung, Klenerman, Paul, Kriegstein, Arnold, Lein, Ed, Linnarsson, Sten, Lundberg, Emma, Lundeberg, Joakim, Majumder, Partha, Marioni, John C, Merad, Miriam, Mhlanga, Musa, Nawijn, Martijn, Netea, Mihai, Nolan, Garry, Pe'er, Dana, Phillipakis, Anthony, Ponting, Chris P, Quake, Stephen, Reik, Wolf, Rozenblatt-Rosen, Orit, Sanes, Joshua, Satija, Rahul, Schumacher, Ton N, Shalek, Alex, Shapiro, Ehud, Sharma, Padmanee, Shin, Jay W, Stegle, Oliver, Stratton, Michael, Stubbington, Michael J T, Theis, Fabian J, Uhlen, Matthias, van Oudenaarden, Alexander, Wagner, Allon, Watt, Fiona, Weissman, Jonathan, Wold, Barbara, Xavier, Ramnik, Yosef, Nir

“…The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is…”
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Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission by Rivett, Lucy, Sridhar, Sushmita, Sparkes, Dominic, Routledge, Matthew, Jones, Nick K, Forrest, Sally, Young, Jamie, Pereira-Dias, Joana, Hamilton, William L, Ferris, Mark, Torok, M Estee, Meredith, Luke, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Samworth, Richard J, Bradley, John R, Dougan, Gordon, Smith, Kenneth Gc, Lehner, Paul J, Matheson, Nicholas J, Wright, Giles, Goodfellow, Ian G, Baker, Stephen, Weekes, Michael P

“…Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening…”
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Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset by Karlinsky, Ariel, Kobak, Dmitry

“…Comparing the impact of the COVID-19 pandemic between countries or across time is difficult because the reported numbers of cases and deaths can be strongly…”
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A consensus guide to capturing the ability to inhibit actions and impulsive behaviors in the stop-signal task by Verbruggen, Frederick, Aron, Adam R, Band, Guido Ph, Beste, Christian, Bissett, Patrick G, Brockett, Adam T, Brown, Joshua W, Chamberlain, Samuel R, Chambers, Christopher D, Colonius, Hans, Colzato, Lorenza S, Corneil, Brian D, Coxon, James P, Dupuis, Annie, Eagle, Dawn M, Garavan, Hugh, Greenhouse, Ian, Heathcote, Andrew, Huster, René J, Jahfari, Sara, Kenemans, J Leon, Leunissen, Inge, Li, Chiang-Shan R, Logan, Gordon D, Matzke, Dora, Morein-Zamir, Sharon, Murthy, Aditya, Paré, Martin, Poldrack, Russell A, Ridderinkhof, K Richard, Robbins, Trevor W, Roesch, Matthew, Rubia, Katya, Schachar, Russell J, Schall, Jeffrey D, Stock, Ann-Kathrin, Swann, Nicole C, Thakkar, Katharine N, van der Molen, Maurits W, Vermeylen, Luc, Vink, Matthijs, Wessel, Jan R, Whelan, Robert, Zandbelt, Bram B, Boehler, C Nico

“…Response inhibition is essential for navigating everyday life. Its derailment is considered integral to numerous neurological and psychiatric disorders, and…”
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SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway by Khan, Shahanshah, Shafiei, Mahnoush S, Longoria, Christopher, Schoggins, John W, Savani, Rashmin C, Zaki, Hasan

“…The pathogenesis of COVID-19 is associated with a hyperinflammatory response; however, the precise mechanism of SARS-CoV-2-induced inflammation is poorly…”
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Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics by Barton, Michael I, MacGowan, Stuart A, Kutuzov, Mikhail A, Dushek, Omer, Barton, Geoffrey John, van der Merwe, P Anton

“…The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of…”
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N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2 by Tian, Fang, Tong, Bei, Sun, Liang, Shi, Shengchao, Zheng, Bin, Wang, Zibin, Dong, Xianchi, Zheng, Peng

“…SARS-CoV-2 has been spreading around the world for the past year. Recently, several variants such as B.1.1.7 (alpha), B.1.351 (beta), and P.1 (gamma), which…”
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YTHDC1 mediates nuclear export of N 6 -methyladenosine methylated mRNAs by Roundtree, Ian A, Luo, Guan-Zheng, Zhang, Zijie, Wang, Xiao, Zhou, Tao, Cui, Yiquang, Sha, Jiahao, Huang, Xingxu, Guerrero, Laura, Xie, Phil, He, Emily, Shen, Bin, He, Chuan

“…-methyladenosine (m A) is the most abundant internal modification of eukaryotic messenger RNA (mRNA) and plays critical roles in RNA biology. The function of…”
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Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data by Racle, Julien, de Jonge, Kaat, Baumgaertner, Petra, Speiser, Daniel E, Gfeller, David

“…Immune cells infiltrating tumors can have important impact on tumor progression and response to therapy. We present an efficient algorithm to simultaneously…”
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Common activation mechanism of class A GPCRs by Zhou, Qingtong, Yang, Dehua, Wu, Meng, Guo, Yu, Guo, Wanjing, Zhong, Li, Cai, Xiaoqing, Dai, Antao, Jang, Wonjo, Shakhnovich, Eugene I, Liu, Zhi-Jie, Stevens, Raymond C, Lambert, Nevin A, Babu, M Madan, Wang, Ming-Wei, Zhao, Suwen

“…Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human physiology. Understanding receptor activation mechanism is critical for…”
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COVID-19 medical papers have fewer women first authors than expected by Andersen, Jens Peter, Nielsen, Mathias Wullum, Simone, Nicole L, Lewiss, Resa E, Jagsi, Reshma

“…The COVID-19 pandemic has resulted in school closures and distancing requirements that have disrupted both work and family life for many. Concerns exist that…”
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Brian 2, an intuitive and efficient neural simulator by Stimberg, Marcel, Brette, Romain, Goodman, Dan Fm

“…Brian 2 allows scientists to simply and efficiently simulate spiking neural network models. These models can feature novel dynamical equations, their…”
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Ten simple rules for the computational modeling of behavioral data by Wilson, Robert C, Collins, Anne Ge

“…Computational modeling of behavior has revolutionized psychology and neuroscience. By fitting models to experimental data we can probe the algorithms…”
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CaImAn an open source tool for scalable calcium imaging data analysis by Giovannucci, Andrea, Friedrich, Johannes, Gunn, Pat, Kalfon, Jérémie, Brown, Brandon L, Koay, Sue Ann, Taxidis, Jiannis, Najafi, Farzaneh, Gauthier, Jeffrey L, Zhou, Pengcheng, Khakh, Baljit S, Tank, David W, Chklovskii, Dmitri B, Pnevmatikakis, Eftychios A

“…Advances in fluorescence microscopy enable monitoring larger brain areas in-vivo with finer time resolution. The resulting data rates require reproducible…”
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