Association Between Mast Cells and Collagen Maturation in Chronic Periodontitis in Humans
Mast cells (MCs) can influence the maturation of collagen fibers. This study evaluated the relationship between the distribution and degranulation of MCs and collagen maturation in human gingival tissue in chronic periodontitis. A total of 16 specimens of patients clinically diagnosed as periodontit...
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| Published in: | The journal of histochemistry and cytochemistry Vol. 66; no. 6; pp. 467 - 475 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Los Angeles, CA
SAGE Publications
01-06-2018
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Mast cells (MCs) can influence the maturation of collagen fibers. This study evaluated the relationship between the distribution and degranulation of MCs and collagen maturation in human gingival tissue in chronic periodontitis. A total of 16 specimens of patients clinically diagnosed as periodontitis and 18 controls clinically diagnosed as healthy or gingivitis were included. Immunohistochemistry and Picrosirius staining were performed to identify MCs and assess collagen fibers, respectively. Chi-square, t test, and Pearson’s correlation test (p<0.05) were used. In control specimens, there was a positive association between MCs in the connective tissue and the presence of immature collagen (p=0.001); in periodontitis samples, this association was not confirmed (p≥0.12). There was no significant relationship between periodontal diagnosis and collagen maturation or MC degranulation (p≥0.35). MC density was significantly higher (p=0.04) in periodontitis tissue (339.01 ± 188.94 MCs/mm2) than in control tissue (211.14 ± 131.13 MCs/mm2) in the area of connective tissue containing inflammatory infiltrate. There was a correlation between the number of MCs and probing depth (r = 0.34, p=0.04). MCs are involved in the pathogenesis of periodontal diseases and might be associated with collagen maturation in periodontal tissue during the early stages of periodontal disease pathogenesis. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0022-1554 1551-5044 |
| DOI: | 10.1369/0022155418765131 |