Search Results - "du Plessis, Lissinda H."

Review of natural compounds for potential skin cancer treatment by Chinembiri, Tawona N, du Plessis, Lissinda H, Gerber, Minja, Hamman, Josias H, du Plessis, Jeanetta

“…Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive…”
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The influence of viscosity of hydrogels on the spreading and migration of cells in 3D bioprinted skin cancer models by Du Plessis, Lissinda H, Gouws, Chrisna, Nieto, Daniel

“…Various three-dimensional (3D) tissue culture models of human and diseased skin exist. Nevertheless, there is still room for the development and improvement of…”
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Immunogenic profile of a plant-produced nonavalent African horse sickness viral protein 2 (VP2) vaccine in IFNAR-/- mice by O'Kennedy, Martha M, Roth, Robyn, Ebersohn, Karen, du Plessis, Lissinda H, Mamputha, Sipho, Rutkowska, Daria A, du Preez, Ilse, Verschoor, Jan A, Lemmer, Yolandy

“…A safe, highly immunogenic multivalent vaccine to protect against all nine serotypes of African horse sickness virus (AHSV), will revolutionise the AHS vaccine…”
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Developing Self-Nanoemulsifying Drug Delivery Systems Comprising an Artemether-Lumefantrine Fixed-Dose Combination to Treat Malaria by Viljoen, Joe M, Cilliers, Lauren, du Plessis, Lissinda H

“…Despite attempts to control malaria, poor drug bioavailability means malaria still places enormous pressure on health globally. It has been found that the…”
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Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro by Wentzel, Johannes F., Lewies, Angélique, Bronkhorst, Abel J., van Dyk, Etresia, du Plessis, Lissinda H., Pretorius, Piet J.

“…In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase…”
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Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria by Seo, Eun Bin, du Plessis, Lissinda H, Viljoen, Joe M

“…Malaria affects millions of people annually, especially in third-world countries. The mainstay of treatment is oral anti-malarial drugs and vaccination. An…”
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Direct compression of chitosan: process and formulation factors to improve powder flow and tablet performance by Buys, Gerhard M, du Plessis, Lissinda H, Marais, Andries F, Kotze, Awie F, Hamman, Josias H

“…Chitosan is a polymer derived from chitin that is widely available at relatively low cost, but due to compression challenges it has limited application for the…”
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Anti-Melanoma Activities of Artemisone and Prenylated Amino-Artemisinins in Combination With Known Anticancer Drugs by Wong, Ho Ning, Lewies, Angélique, Haigh, Michaela, Viljoen, Joe M., Wentzel, Johannes F., Haynes, Richard K., du Plessis, Lissinda H.

“…The most frequently occurring cancers are those of the skin, with melanoma being the leading cause of death due to skin cancer. Breakthroughs in chemotherapy…”
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Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion by Wilkins, Christi A., du Plessis, Lissinda H., Viljoen, Joe M.

“…Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden,…”
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In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum by Du Plessis, Lissinda H, van Niekerk, Anel C, Maritz, Marlene M, Kotzé, Awie F

“…The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been…”
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Development of a Plant-Expressed Subunit Vaccine against Brucellosis by Rutkowska, Daria A, Du Plessis, Lissinda H, Suleman, Essa, O'Kennedy, Martha M, Thimiri Govinda Raj, Deepak B, Lemmer, Yolandy

“…Brucellosis is an important bacterial disease of livestock and the most common zoonotic disease. The current vaccines are effective but unsafe, as they result…”
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Lewies, A., et al. The Potential Use of Natural and Structural Analogues of Antimicrobial Peptides in the Fight against Neglected Tropical Diseases. Molecules 2015, 20, 15392–15433 by Lewies, Angélique, Wentzel, Johannes, Jacobs, Garmi, Plessis, Lissinda

“…The authors wish to make the following corrections to this paper [1]: [...]…”
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Antimicrobial Peptides: the Achilles’ Heel of Antibiotic Resistance? by Lewies, Angélique, Du Plessis, Lissinda H., Wentzel, Johannes F.

“…Antibiotic resistance is an imminent threat to the effective treatment of bacterial infections, and alternative antibiotic strategies are urgently required…”
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Applications of lipid based formulation technologies in the delivery of biotechnology-based therapeutics by du Plessis, Lissinda H, Marais, Etienne B, Mohammed, Faruq, Kotzé, Awie F

“…In the last decades several new biotechnologically-based therapeutics have been developed due to progress in genetic engineering. A growing challenge facing…”
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Flow cytometry as an analytical method of drug-induced apoptosis in 3D bioprinted melanoma cells by de Villiers, Maryke, Du Plessis, Lissinda H

“…Three-dimensional (3D) cell culture systems have gained increasing interest in drug discovery and tissue engineering due to its inherent advantages in…”
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Evaluation of the cytotoxic properties, gene expression profiles and secondary signalling responses of cultured cells exposed to fumonisin B1, deoxynivalenol and zearalenone mycotoxins by Wentzel, Johannes F., Lombard, Martani J., Du Plessis, Lissinda H., Zandberg, Lizelle

“…Mycotoxins are toxic secondary metabolites produced by a range of fungi and are common contaminants of agricultural crops. These toxins are chemically diverse…”
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In vivo efficacy and bioavailability of lumefantrine: Evaluating the application of Pheroid technology by du Plessis, Lissinda H., Govender, Katya, Denti, Paolo, Wiesner, Lubbe

“…[Display omitted] The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is typically limited by the dissolution rate in the…”
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Characterization of solid lipid dispersions prepared by hot fusion containing a double-fixed dose combination of artemether and lumefantrine by Wilkins, Christi A., du Plessis, Lissinda H., Viljoen, Joe M.

“…The World Health Organization has called for the development of novel drug delivery systems to combat malaria - the fourth most prevalent cause of death…”
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In‐vitro cytotoxicity of various Siphonochilus aethiopicus (Schweinf.) B.L. Burtt extracts in combination with selected tableting excipients by Erasmus, Mandi, Plessis, Lissinda H., Viljoen, Joe M.

“…Objectives To investigate the cytotoxic potential of S. aethiopicus extracts in combination with chitosan and Pharmacel®101, on two cell lines. Methods…”
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In vitro evaluation of the cytotoxic and apoptogenic properties of aloe whole leaf and gel materials by du Plessis, Lissinda H., Hamman, Josias H.

“…Abstract Aloe gel and whole-leaf materials have shown biological effects with potential therapeutic applications, and recently, their drug-absorption…”
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