Search Results - "du Plessis, Lissinda"

Review of natural compounds for potential skin cancer treatment by Chinembiri, Tawona N, du Plessis, Lissinda H, Gerber, Minja, Hamman, Josias H, du Plessis, Jeanetta

“…Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive…”
Get full text

The Potential Use of Natural and Structural Analogues of Antimicrobial Peptides in the Fight against Neglected Tropical Diseases by Lewies, Angélique, Wentzel, Johannes F, Jacobs, Garmi, Du Plessis, Lissinda H, Angélique, Lewies, Frederik, Wentzel Johannes, Garmi, Jacobs, Hester, Du Plessis Lissinda

“…Recently, research into the development of new antimicrobial agents has been driven by the increase in resistance to traditional antibiotics and Emerging…”
Get full text

The influence of viscosity of hydrogels on the spreading and migration of cells in 3D bioprinted skin cancer models by Du Plessis, Lissinda H, Gouws, Chrisna, Nieto, Daniel

“…Various three-dimensional (3D) tissue culture models of human and diseased skin exist. Nevertheless, there is still room for the development and improvement of…”
Get full text

Immunogenic profile of a plant-produced nonavalent African horse sickness viral protein 2 (VP2) vaccine in IFNAR-/- mice by O'Kennedy, Martha M, Roth, Robyn, Ebersohn, Karen, du Plessis, Lissinda H, Mamputha, Sipho, Rutkowska, Daria A, du Preez, Ilse, Verschoor, Jan A, Lemmer, Yolandy

“…A safe, highly immunogenic multivalent vaccine to protect against all nine serotypes of African horse sickness virus (AHSV), will revolutionise the AHS vaccine…”
Get full text

Intestinal Drug Absorption Enhancement by Aloe vera Gel and Whole Leaf Extract: In Vitro Investigations into the Mechanisms of Action by Haasbroek, Anja, Willers, Clarissa, Glyn, Matthew, du Plessis, Lissinda, Hamman, Josias

“…The co-administration of absorption enhancing agents with macromolecular drugs (e.g., protein and peptide drugs) has been identified as a means to improve the…”
Get full text

Developing Self-Nanoemulsifying Drug Delivery Systems Comprising an Artemether-Lumefantrine Fixed-Dose Combination to Treat Malaria by Viljoen, Joe M, Cilliers, Lauren, du Plessis, Lissinda H

“…Despite attempts to control malaria, poor drug bioavailability means malaria still places enormous pressure on health globally. It has been found that the…”
Get full text

Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro by Wentzel, Johannes F., Lewies, Angélique, Bronkhorst, Abel J., van Dyk, Etresia, du Plessis, Lissinda H., Pretorius, Piet J.

“…In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase…”
Get full text

Eudragit® L100/N-trimethylchitosan chloride microspheres for oral insulin delivery by Marais, Etienne, Hamman, Josias, Plessis, Lissinda du, Lemmer, Righard, Steenekamp, Jan

“…Effective oral delivery of protein and peptide drugs remains an active topic in scientific research. In this study, matrix type microspheres were prepared with…”
Get full text

Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria by Seo, Eun Bin, du Plessis, Lissinda H, Viljoen, Joe M

“…Malaria affects millions of people annually, especially in third-world countries. The mainstay of treatment is oral anti-malarial drugs and vaccination. An…”
Get full text

Anti-Melanoma Activities of Artemisone and Prenylated Amino-Artemisinins in Combination With Known Anticancer Drugs by Wong, Ho Ning, Lewies, Angélique, Haigh, Michaela, Viljoen, Joe M., Wentzel, Johannes F., Haynes, Richard K., du Plessis, Lissinda H.

“…The most frequently occurring cancers are those of the skin, with melanoma being the leading cause of death due to skin cancer. Breakthroughs in chemotherapy…”
Get full text

Topical Delivery of Withania somnifera Crude Extracts in Niosomes and Solid Lipid Nanoparticles by Chinembiri, Tawona N, Gerber, Minja, du Plessis, Lissinda H, du Preez, Jan L, Hamman, Josias H, du Plessis, Jeanetta

“…is a medicinal plant native to India and is known to have anticancer properties. It has been investigated for its anti-melanoma properties, and since melanoma…”
Get full text

Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion by Wilkins, Christi A., du Plessis, Lissinda H., Viljoen, Joe M.

“…Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden,…”
Get full text

Development of a Plant-Expressed Subunit Vaccine against Brucellosis by Rutkowska, Daria A, Du Plessis, Lissinda H, Suleman, Essa, O'Kennedy, Martha M, Thimiri Govinda Raj, Deepak B, Lemmer, Yolandy

“…Brucellosis is an important bacterial disease of livestock and the most common zoonotic disease. The current vaccines are effective but unsafe, as they result…”
Get full text

Antimicrobial Peptides: the Achilles’ Heel of Antibiotic Resistance? by Lewies, Angélique, Du Plessis, Lissinda H., Wentzel, Johannes F.

“…Antibiotic resistance is an imminent threat to the effective treatment of bacterial infections, and alternative antibiotic strategies are urgently required…”
Get full text

Characterization of the cell-free DNA released by cultured cancer cells by Bronkhorst, Abel Jacobus, Wentzel, Johannes F., Aucamp, Janine, van Dyk, Etresia, du Plessis, Lissinda, Pretorius, Piet J.

“…The most prominent factor that delays the translation of cell-free DNA (cfDNA) analyses to clinical practice is the lack of knowledge regarding its origin and…”
Get full text

In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum by Du Plessis, Lissinda H, van Niekerk, Anel C, Maritz, Marlene M, Kotzé, Awie F

“…The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been…”
Get full text

Direct compression of chitosan: process and formulation factors to improve powder flow and tablet performance by Buys, Gerhard M, du Plessis, Lissinda H, Marais, Andries F, Kotze, Awie F, Hamman, Josias H

“…Chitosan is a polymer derived from chitin that is widely available at relatively low cost, but due to compression challenges it has limited application for the…”
Get more information

Flow cytometry as an analytical method of drug-induced apoptosis in 3D bioprinted melanoma cells by de Villiers, Maryke, Du Plessis, Lissinda H

“…Three-dimensional (3D) cell culture systems have gained increasing interest in drug discovery and tissue engineering due to its inherent advantages in…”
Get more information

Evaluation of the cytotoxic properties, gene expression profiles and secondary signalling responses of cultured cells exposed to fumonisin B1, deoxynivalenol and zearalenone mycotoxins by Wentzel, Johannes F., Lombard, Martani J., Du Plessis, Lissinda H., Zandberg, Lizelle

“…Mycotoxins are toxic secondary metabolites produced by a range of fungi and are common contaminants of agricultural crops. These toxins are chemically diverse…”
Get full text

In vivo efficacy and bioavailability of lumefantrine: Evaluating the application of Pheroid technology by du Plessis, Lissinda H., Govender, Katya, Denti, Paolo, Wiesner, Lubbe

“…[Display omitted] The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is typically limited by the dissolution rate in the…”
Get full text