Search Results - "du Bois, R"

Strategies for treating idiopathic pulmonary fibrosis by du Bois, R. M

“…Key Points Idiopathic pulmonary fibrosis (IPF) is the most common form of idiopathic interstitial pneumonia (IIP), a group of diseases of unknown cause that…”
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Marginal decline in forced vital capacity is associated with a poor outcome in idiopathic pulmonary fibrosis by Zappala, C. J, Latsi, P. I, Nicholson, A. G, Colby, T. V, Cramer, D, Renzoni, E. A, Hansell, D. M, du Bois, R. M, Wells, A. U

“…In therapeutic studies in idiopathic pulmonary fibrosis (IPF), the low prevalence of significant change in pulmonary functional tests (PFTs) has been a major…”
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Approaches to the treatment of some of the troublesome manifestations of sarcoidosis by Eklund, A., Bois, R. M.

“…Sarcoidosis can be a major therapeutic challenge given its multiplicity of clinical presentations, variable combination of organ involvement and severity, and…”
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Echocardiography and pulmonary function as screening tests for pulmonary arterial hypertension in systemic sclerosis by Mukerjee, D., St. George, D., Knight, C., Davar, J., Wells, A. U., Du Bois, R. M., Black, C. M., Coghlan, J. G.

“…Objective. A prospective study to evaluate echocardiography and gas transfer (DLCO) by comparison with cardiac catheterization in discriminating between…”
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Variations in histological patterns of interstitial pneumonia between connective tissue disorders and their relationship to prognosis by Tansey, D, Wells, A U, Colby, T V, Ip, S, Nikolakoupolou, A, Du Bois, R M, Hansell, D M, Nicholson, A G

“…Aims and methods:  Pulmonary parenchymal disease is common in patients with connective tissue disorders (CTDs). However, most reports precede recognition of…”
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Genetics of fibrosing lung diseases by Grutters, J. C, du Bois, R. M

“…Genetic studies in familial lung fibrosis have demonstrated an association with surfactant protein C genes: two mutations have been found resulting in protein…”
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Clinical response to morphine in cancer patients and genetic variation in candidate genes by Ross, J R, Rutter, D, Welsh, K, Joel, S P, Goller, K, Wells, A U, Du Bois, R, Riley, J

“…Morphine is the analgesic of choice for moderate to severe cancer pain; however, 10-30% of patients do not tolerate morphine. This study evaluated genetic…”
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Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF by Lawson, W E, Grant, S W, Ambrosini, V, Womble, K E, Dawson, E P, Lane, K B, Markin, C, Renzoni, E, Lympany, P, Thomas, A Q, Roldan, J, Scott, T A, Blackwell, T S, Phillips, J A, Loyd, J E, du Bois, R M

“…Background: While idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease, the aetiology of IPF is poorly understood…”
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CARD15/NOD2 polymorphisms are associated with severe pulmonary sarcoidosis by Sato, H, Williams, H. R. T, Spagnolo, P, Abdallah, A, Ahmad, T, Orchard, T. R, Copley, S. J, Desai, S. R, Wells, A. U, du Bois, R. M, Welsh, K. I

“…Sarcoidosis and Crohn's disease are heterogeneous systemic diseases characterised by granulomatous inflammation. Caspase recruitment domain (CARD)15 is a major…”
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Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis by Beirne, P, Pantelidis, P, Charles, P, Wells, A. U, Abraham, D. J, Denton, C. P, Welsh, K. I, Shah, P. L, du Bois, R. M, Kelleher, P

“…Multiplex protein technology has the potential to identify biomarkers for the differentiation, classification and improved understanding of the pathogenesis of…”
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T-helper cell type-1 transcription factor T-bet is upregulated in pulmonary sarcoidosis by KRIEGOVA, E, FILLEROVA, R, TOMANKOVA, T, HUTYROVA, B, MRAZEK, F, TICHY, T, KOLEK, V, DU BOIS, R. M, PETREK, M

“…Upregulation of genes for interferon (IFN)-γ and CXC chemokine receptor (CXCR)3 expression, two crucial molecules in sarcoid inflammation and granuloma…”
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Quality of life and dyspnoea in patients treated with bosentan for idiopathic pulmonary fibrosis (BUILD-1) by Raghu, G, King, T. E., Jr, Behr, J, Brown, K. K, du Bois, R. M, Leconte, I, Roux, S, Swigris, J

“…No therapy is known to improve health-related quality of life (HRQoL) or dyspnoea in patients with idiopathic pulmonary fibrosis. The present study…”
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X‑ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly by Yang, Hyunjun, Wierzbicki, Michał, Du Bois, Derek R, Nowick, James S

“…This paper describes the X-ray crystallographic structure of a derivative of the antibiotic teixobactin and shows that its supramolecular assembly through the…”
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Increased epithelial permeability in pulmonary fibrosis in relation to disease progression by GOH, N. S. L, DESAI, S. R, ANAGNOSTOPOULOS, C, HANSELL, D. M, HOYLES, R. K, SATO, H, DENTON, C. P, BLACK, C. M, DU BOIS, R. M, WELLS, A. U

“…Epithelial injury contributes to pathogenesis in idiopathic pulmonary fibrosis (IPF) but its role in the interstitial lung disease (ILD) of systemic sclerosis…”
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Desquamative interstitial pneumonia, respiratory bronchiolitis and their relationship to smoking by Craig, P J, Wells, A U, Doffman, S, Rassl, D, Colby, T V, Hansell, D M, Du Bois, R M, Nicholson, A G

“…Aims : Respiratory bronchiolitis (RB) and desquamative interstitial pneumonia (DIP) are closely associated histological patterns of interstitial pneumonia,…”
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Sarcoidosis by Baughman, Robert P, Lower, Elyse E, du Bois, Roland M

“…There have been several new insights into the cause and treatment of sarcoidosis. Studies of genetic variation have shown that specific genetic polymorphisms…”
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A common haplotype of the C‐C chemokine receptor 2 gene and HLA‐DRB10301 are independent genetic risk factors for Löfgren’s syndrome by Spagnolo, P., Sato, H., Grunewald, J., Brynedal, B., Hillert, J., Mañá, J., Wells, A. U., Eklund, A., Welsh, K. I., Du Bois, R. M.

“… Aim.  Sarcoidosis is a heterogeneous disorder with a strong genetic influence. Genetic factors are also thought to influence disease severity and outcome. We…”
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Is there a role for microorganisms in the pathogenesis of sarcoidosis? by Du Bois, R. M., Goh, N., McGrath, D., Cullinan, P.

“…  du Bois RM, Goh N, McGrath D, Cullinan P (Royal Brompton Hospital and Imperial College, London, UK). Is there a role for microorganisms in the pathogenesis…”
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BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia by Veeraraghavan, S, Latsi, P.I, Wells, A.U, Pantelidis, P, Nicholson, A.G, Colby, T.V, Haslam, P.L, Renzoni, E.A, du Bois, R.M

“…Idiopathic pulmonary fibrosis (IPF), which has the histological pattern of usual interstitial pneumonia (UIP), is a progressive interstitial lung disease with…”
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Exercise peripheral oxygen saturation (SpO2) accurately reflects arterial oxygen saturation (SaO2) and predicts mortality in systemic sclerosis by Swigris, J J, Zhou, X, Wamboldt, F S, du Bois, R, Keith, R, Fischer, A, Cosgrove, G P, Frankel, S K, Curran-Everett, D, Brown, K K

“…Measures of oxygenation have not been assessed for prognostic significance in systemic sclerosis-related interstitial lung disease (SSc-ILD). 83 subjects with…”
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