Search Results - "dos Santos Guilherme, Malena"

Shotgun lipidomics of liver and brain tissue of Alzheimer’s disease model mice treated with acitretin by Lauer, Anna A., Janitschke, Daniel, dos Santos Guilherme, Malena, Nguyen, Vu Thu Thuy, Bachmann, Cornel M., Qiao, Sen, Schrul, Bianca, Boehm, Ulrich, Grimm, Heike S., Hartmann, Tobias, Endres, Kristina, Grimm, Marcus O. W.

“…Alzheimer’s disease (AD) is a very frequent neurodegenerative disorder characterized by an accumulation of amyloid-β (Aβ). Acitretin, a retinoid-derivative and…”
Get full text

Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease by Rosales Jubal, Eduardo, Schwalm, Miriam, dos Santos Guilherme, Malena, Schuck, Florian, Reinhardt, Sven, Tose, Amanda, Barger, Zeke, Roesler, Mona K., Ruffini, Nicolas, Wierczeiko, Anna, Schmeisser, Michael J., Schmitt, Ulrich, Endres, Kristina, Stroh, Albrecht

“…Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed in microcircuits…”
Get full text

Behavioral Phenotyping of Bbs6 and Bbs8 Knockout Mice Reveals Major Alterations in Communication and Anxiety by Rödig, Nathalie, Sellmann, Kristin, Dos Santos Guilherme, Malena, Nguyen, Vu Thu Thuy, Cleppien, Dirk, Stroh, Albrecht, May-Simera, Helen Louise, Endres, Kristina

“…The primary cilium is an organelle with a central role in cellular signal perception. Mutations in genes that encode cilia-associated proteins result in a…”
Get full text

Dietary Wheat Amylase Trypsin Inhibitors Impact Alzheimer's Disease Pathology in 5xFAD Model Mice by Dos Santos Guilherme, Malena, Zevallos, Victor F, Pesi, Aline, Stoye, Nicolai M, Nguyen, Vu Thu Thuy, Radyushkin, Konstantin, Schwiertz, Andreas, Schmitt, Ulrich, Schuppan, Detlef, Endres, Kristina

“…Wheat amylase trypsin inhibitors (ATIs) represent a common dietary protein component of gluten-containing cereals (wheat, rye, and barley). They act as…”
Get full text

Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse by dos Santos Guilherme, Malena, Todorov, Hristo, Osterhof, Carina, Möllerke, Anton, Cub, Kristina, Hankeln, Thomas, Gerber, Susanne, Endres, Kristina

“…Alzheimer’s disease (AD) is the most common form of dementia. Besides its cognitive phenotype, AD leads to crucial changes in gut microbiome composition in…”
Get full text

The Influence of Acitretin on Brain Lipidomics in Adolescent Mice-Implications for Pediatric and Adolescent Dermatological Therapy by Lauer, Anna A, Nguyen, Vu Thu Thuy, Janitschke, Daniel, Dos Santos Guilherme, Malena, Bachmann, Cornel M, Grimm, Heike S, Hartmann, Tobias, Endres, Kristina, Grimm, Marcus O W

“…Administration of systemic retinoids such as acitretin has not been approved yet for pediatric patients. An adverse event of retinoid-therapy that occurs with…”
Get full text

Identification of Patulin from Penicillium coprobium as a Toxin for Enteric Neurons by Brand, Benjamin, Stoye, Nicolai M, Guilherme, Malena Dos Santos, Nguyen, Vu Thu Thuy, Baumgaertner, Julia C, Schüffler, Anja, Thines, Eckhard, Endres, Kristina

“…The identification and characterization of fungal commensals of the human gut (the mycobiota) is ongoing, and the effects of their various secondary…”
Get full text

The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients by Dos Santos Guilherme, Malena, Stoye, Nicolai M, Rose-John, Stefan, Garbers, Christoph, Fellgiebel, Andreas, Endres, Kristina

“…These days, the important role of retinoids in adult brain functionality and homeostasis is well accepted and has been proven by genomic as well as non-genomic…”
Get full text

Resilience and the Gut Microbiome: Insights from Chronically Socially Stressed Wild-Type Mice by dos Santos Guilherme, Malena, Valeri, Francesco, Winter, Jennifer, Müller, Marianne B, Schwiertz, Andreas, Endres, Kristina

“…The microbiome is an important player within physiological homeostasis of the body but also in pathophysiological derailments. Chronic social stress is a…”
Get full text

Selective targeting of chronic social stress-induced activated neurons identifies neurogenesis-related genes to be associated with resilience in female mice by dos Santos Guilherme, Malena, Tsoutsouli, Theodora, Chongtham, Monika Chanu, Winter, Jennifer, Gerber, Susanne, Müller, Marianne B., Endres, Kristina

“…Prolonged social stress is a major cause for depression in humans and is associated with a wide range of subsequent pathophysiological changes such as elevated…”
Get full text

Influence of Acetylcholine Esterase Inhibitors and Memantine, Clinically Approved for Alzheimer's Dementia Treatment, on Intestinal Properties of the Mouse by Nguyen, Vu Thu Thuy, Sallbach, Jason, Dos Santos Guilherme, Malena, Endres, Kristina

“…Four drugs are currently approved for the treatment of Alzheimer's disease (AD) by the FDA. Three of these drugs-donepezil, rivastigmine, and…”
Get full text

Primary Cilia Structure Is Prolonged in Enteric Neurons of 5xFAD Alzheimer's Disease Model Mice by Nguyen, Vu Thu Thuy, Brücker, Lena, Volz, Ann-Kathrin, Baumgärtner, Julia C, Dos Santos Guilherme, Malena, Valeri, Francesco, May-Simera, Helen, Endres, Kristina

“…Neurodegenerative diseases such as Alzheimer's disease (AD) have long been acknowledged as mere disorders of the central nervous system (CNS). However, in…”
Get full text

Impact of Gut Microbiome Manipulation in 5xFAD Mice on Alzheimer's Disease-Like Pathology by Guilherme, Malena Dos Santos, Nguyen, Vu Thu Thuy, Reinhardt, Christoph, Endres, Kristina

“…The gut brain axis seems to modulate various psychiatric and neurological disorders such as Alzheimer's disease (AD). Growing evidence has led to the…”
Get full text

Impact of the Age of Cecal Material Transfer Donors on Alzheimer's Disease Pathology in 5xFAD Mice by Valeri, Francesco, Dos Santos Guilherme, Malena, He, Fuqian, Stoye, Nicolai M, Schwiertz, Andreas, Endres, Kristina

“…Alzheimer's disease is a progressive neurodegenerative disorder affecting around 30 million patients worldwide. The predominant sporadic variant remains…”
Get full text

N6 -Methyladenosine Modification in Chronic Stress Response Due to Social Hierarchy Positioning of Mice by dos Santos Guilherme, Malena, Tsoutsouli, Theodora, Todorov, Hristo, Teifel, Sina, Nguyen, Vu Thu Thuy, Gerber, Susanne, Endres, Kristina

“…Appropriately responding to stressful events is essential for maintaining health and well-being of any organism. Concerning social stress, the response is not…”
Get full text

Alzheimer's disease in the gut—Major changes in the gut of 5xFAD model mice with ApoA1 as potential key player by Stoye, Nicolai M., Santos Guilherme, Malena, Endres, Kristina

“…Alzheimer's disease (AD) affects around 33 million people worldwide, which makes it the most prominent form of dementia. The main focus of AD research has been…”
Get full text

Apolipoprotein A1 in Cerebrospinal Fluid Is Insufficient to Distinguish Alzheimer’s Disease from Other Dementias in a Naturalistic, Clinical Setting by Stoye, Nicolai Maximilian, Jung, Patrick, Guilherme, Malena dos Santos, Lotz, Johannes, Fellgiebel, Andreas, Endres, Kristina

“…Apolipoprotein A1 (ApoA1) is the major protein component of the high-density lipoprotein and involved in cholesterol transport. Disruption of cholesterol…”
Get full text