Search Results - "dos Santos, Bruna"
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ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles
Published in Pharmaceutical research (01-11-2019)“…Purpose Apolipoprotein E2 (ApoE2) gene therapy is a potential disease-modifying therapy for Alzheimer’s disease (AD). We investigated the potential of plasmid…”
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Dual functionalized liposomes for efficient co-delivery of anti-cancer chemotherapeutics for the treatment of glioblastoma
Published in Journal of controlled release (10-08-2019)“…Glioblastoma is a hostile brain tumor associated with high infiltration leading to poor prognosis. Anti-cancer chemotherapeutic agents have limited access into…”
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3
Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties
Published in International journal of nanomedicine (01-01-2019)“…The potential of gene therapy for treatment of neurological disorders can be explored using designed lipid-based nanoparticles such as liposomes, which have…”
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Efficient neuronal targeting and transfection using RVG and transferrin-conjugated liposomes
Published in Brain research (01-05-2020)“…Effective transport of therapeutic nucleic acid to brain has been a challenge for the success of gene therapy for treating brain diseases. In this study, we…”
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Adult human neurogenesis: early studies clarify recent controversies and go further
Published in Metabolic brain disease (2022)“…Evidence on adult mammalian neurogenesis and scarce studies with human brains led to the idea that adult human neurogenesis occurs in the subgranular zone…”
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Ectonucleotidase activity driven by acid ectophosphatase in luminal A MCF‐7 breast cancer cells
Published in Cell biology international (01-11-2024)“…Ectophosphatases catalyse the hydrolysis of phosphorylated molecules, such as phospho‐amino acids, in the extracellular environment. Nevertheless, the…”
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Seasonal and elevational variability in the induction of specialized compounds from mountain birch (Betula pubescens var. pumila) by winter moth larvae (Operophtera brumata)
Published in Tree physiology (07-06-2021)“…Abstract The mountain birch [Betula pubescens var. pumila (L.)] forest in the Subarctic is periodically exposed to insect outbreaks, which are expected to…”
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Immune response of adult horses, pregnant mares and foals to an experimental vaccine with recombinant EMA-2 protein of Theileria equi
Published in Research in veterinary science (01-10-2021)“…Equine theileriosis, caused by the Theileria equi protozoan, is a disease of worldwide importance. T. equi expresses surface proteins, of which the EMA-2…”
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Genetic susceptibility in Juvenile Myoclonic Epilepsy: Systematic review of genetic association studies
Published in PloS one (21-06-2017)“…Several genetic association investigations have been performed over the last three decades to identify variants underlying Juvenile Myoclonic Epilepsy (JME)…”
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Nursing interventions in autologous stem cell transplantation for autoimmune diseases
Published in Journal of advanced nursing (01-12-2020)“…Aims To identify clinical symptoms and nursing interventions for stem cell therapy in autoimmune diseases. Design This is a retrospective, cross‐sectional…”
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Serum biochemistry panel of free‐living red‐handed howler monkeys (Alouatta belzebul) in the Eastern Amazon
Published in Journal of medical primatology (01-02-2022)“…Background The red‐handed howler monkey (Alouatta belzebul) is one of 116 imperiled Brazilian primate species. We aimed to determine the serum biochemical…”
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In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach
Published in International journal of molecular sciences (01-05-2021)“…The liver is among the most frequently targeted organs by noxious chemicals of diverse nature. Liver toxicity testing using laboratory animals not only raises…”
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13
Zinc deficiency disrupts pain signaling promoting nociceptive but not inflammatory pain in mice
Published in Anais da Academia Brasileira de Ciências (01-01-2023)“…Abstract Zinc (Zn) is an essential micronutrient involved in the physiology of nervous system and pain modulation. There is little evidence for the role of…”
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Glucocorticoid modulates oxidative and thermogenic function of rat brown adipose tissue and human brown adipocytes
Published in Journal of cellular physiology (01-09-2024)“…Chronic and excessive glucocorticoid (GC) exposure can cause Cushing's syndrome, resulting in fat accumulation in selected body areas. Particularly in the…”
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Metabolic profile and body condition score of Crioulo horses finalists in the Freio de Ouro competition
Published in Semina. Ciências agrárias : revista cultural e científica da Universidade Estadual de Londrina (01-11-2023)“…The aim of this study was to assess the body condition score (BCS) and metabolic profile of finalists in the Freio de Ouro competition, stratified by sex. This…”
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Hepatic glycogen storage diseases are associated to microbial dysbiosis
Published in PloS one (02-04-2019)“…The gut microbiome has been related to several features present in Glycogen Storage Diseases (GSD) patients including obesity, inflammatory bowel disease (IBD)…”
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Data Instrumentation from IoT Network Traffic as Support for Security Management
Published in IEEE eTransactions on network and service management (01-06-2023)“…The Internet of Things revolutionizes human life by inaugurating scenarios such as smart homes. However, IoT devices contain much sensitive information about…”
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Expression and Functionality of Connexin-Based Channels in Human Liver Cancer Cell Lines
Published in International journal of molecular sciences (10-11-2021)“…Liver cancer cell lines are frequently used in vitro tools to test candidate anti-cancer agents as well as to elucidate mechanisms of liver carcinogenesis…”
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Global neonatal care and access to human milk
Published in Jornal de pediatria (01-11-2022)Get full text
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Prevalence of the Metabolic Syndrome and its components in the Brazilian adult population
Published in Ciência & saude coletiva (01-11-2020)Get full text
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