Haloperidol-loaded lipid-core polymeric nanocapsules reduce DNA damage in blood and oxidative stress in liver and kidneys of rats

Haloperidol-loaded lipid-core polymeric nanocapsules reduce DNA damage in blood and oxidative stress in liver and kidneys of rats

Haloperidol (HP) nanoencapsulation improves therapeutic efficacy, prolongs the drug action time, and reduces its motor side effects. However, in a view of HP toxicity in organs like liver and kidneys in addition to the lack of knowledge regarding the toxicity of polymeric nanocapsules, our aim was t...

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Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology Vol. 17; no. 4; p. 1
Main Authors: Roversi, Katiane, Benvegnú, Dalila M., Roversi, Karine, Trevizol, Fabíola, Vey, Luciana T., Elias, Fabiana, Fracasso, Rafael, Motta, Mariana H., Ribeiro, Roseane F., dos S. Hausen, Bruna, Moresco, Rafael N., Garcia, Solange C., da Silva, Cristiane B., Burger, Marilise E.
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-04-2015
Springer Nature B.V
Subjects:
Blood
Characterization and Evaluation of Materials
Chemistry and Materials Science
Chronic toxicity
Deoxyribonucleic acid
DNA
Inorganic Chemistry
Kidneys
Lasers
Liver
Materials Science
Nanoparticles
Nanotechnology
Optical Devices
Optics
Oxidative stress
Peroxidation
Photonics
Physical Chemistry
Research Paper
Side effects
Cellular integrity
Oxidative stress
Polymeric nanocapsules
Haloperidol
Nanotoxicology
Nanomedicine
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Summary:Haloperidol (HP) nanoencapsulation improves therapeutic efficacy, prolongs the drug action time, and reduces its motor side effects. However, in a view of HP toxicity in organs like liver and kidneys in addition to the lack of knowledge regarding the toxicity of polymeric nanocapsules, our aim was to verify the influence of HP-nanoformulation on toxicity and oxidative stress markers in the liver and kidneys of rats, also observing the damage caused in the blood. For such, 28 adult male Wistar rats were designated in four experimental groups ( n  = 7) and treated with vehicle (C group), free haloperidol suspension (FH group), blank nanocapsules suspension (B-Nc group), and haloperidol-loaded lipid-core nanocapsules suspension (H-Nc group). The nanocapsules formulation presented the size of approximately 250 nm. All suspensions were administered to the animals (0.5 mg/kg/day-i.p.) for a period of 28 days. Our results showed that FH caused damage in the liver, evidenced by increased lipid peroxidation, plasma levels of aspartate aminotransferase, and alanine aminotransferase, as well as decreased cellular integrity and vitamin C levels. In kidneys, FH treatment caused damage to a lesser extent, observed by decreased activity of δ-aminolevulinate dehydratase (ALA-D) and levels of VIT C. In addition, FH treatment was also related to a higher DNA damage index in blood. On the other hand, animals treated with H-Nc and B-Nc did not show damage in liver, kidneys, and DNA. Our study indicates that the nanoencapsulation of haloperidol was able to prevent the sub-chronic toxicity commonly observed in liver, kidneys, and DNA, thus reflecting a pharmacological superiority in relation to free drug.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-015-2979-4