Search Results - "dos Santos, Ália"

DNA damage alters nuclear mechanics through chromatin reorganization by dos Santos, Ália, Cook, Alexander W, Gough, Rosemarie E, Schilling, Martin, Olszok, Nora A, Brown, Ian, Wang, Lin, Aaron, Jesse, Martin-Fernandez, Marisa L, Rehfeldt, Florian, Toseland, Christopher P

“…Abstract DNA double-strand breaks drive genomic instability. However, it remains unknown how these processes may affect the biomechanical properties of the…”
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Myosin VI regulates the spatial organisation of mammalian transcription initiation by Hari-Gupta, Yukti, Fili, Natalia, dos Santos, Ália, Cook, Alexander W., Gough, Rosemarie E., Reed, Hannah C. W., Wang, Lin, Aaron, Jesse, Venit, Tomas, Wait, Eric, Grosse-Berkenbusch, Andreas, Gebhardt, J. Christof M., Percipalle, Piergiorgio, Chew, Teng-Leong, Martin-Fernandez, Marisa, Toseland, Christopher P.

“…During transcription, RNA Polymerase II (RNAPII) is spatially organised within the nucleus into clusters that correlate with transcription activity. While this…”
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Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription by dos Santos, Ália, Rollins, Daniel E., Hari-Gupta, Yukti, McArthur, Hannah, Du, Mingxue, Ru, Sabrina Yong Zi, Pidlisna, Kseniia, Stranger, Ane, Lorgat, Faeeza, Lambert, Danielle, Brown, Ian, Howland, Kevin, Aaron, Jesse, Wang, Lin, Ellis, Peter J. I., Chew, Teng-Leong, Martin-Fernandez, Marisa, Pyne, Alice L. B., Toseland, Christopher P.

“…NDP52 is an autophagy receptor involved in the recognition and degradation of invading pathogens and damaged organelles. Although NDP52 was first identified in…”
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A Targeted and Tuneable DNA Damage Tool Using CRISPR/Cas9 by Emmanouilidis, Ioannis, Fili, Natalia, Cook, Alexander W, Hari-Gupta, Yukti, Dos Santos, Ália, Wang, Lin, Martin-Fernandez, Marisa L, Ellis, Peter J I, Toseland, Christopher P

“…Mammalian cells are constantly subjected to a variety of DNA damaging events that lead to the activation of DNA repair pathways. Understanding the molecular…”
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Regulation of Nuclear Mechanics and the Impact on DNA Damage by Dos Santos, Ália, Toseland, Christopher P

“…In eukaryotic cells, the nucleus houses the genomic material of the cell. The physical properties of the nucleus and its ability to sense external mechanical…”
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Binding partners regulate unfolding of myosin VI to activate the molecular motor by Dos Santos, Ália, Fili, Natalia, Hari-Gupta, Yukti, Gough, Rosemarie E, Wang, Lin, Martin-Fernandez, Marisa, Aaron, Jesse, Wait, Eric, Chew, Teng-Leong, Toseland, Christopher P

“…Myosin VI is the only minus-end actin motor and it is coupled to various cellular processes ranging from endocytosis to transcription. This multi-potent nature…”
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Atomic Force Microscopy micro-rheology reveals large structural inhomogeneities in single cell-nuclei by Lherbette, Michael, dos Santos, Ália, Hari-Gupta, Yukti, Fili, Natalia, Toseland, Christopher P., Schaap, Iwan A. T.

“…During growth, differentiation and migration of cells, the nucleus changes size and shape, while encountering forces generated by the cell itself and its…”
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NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription by Fili, Natalia, Hari-Gupta, Yukti, dos Santos, Ália, Cook, Alexander, Poland, Simon, Ameer-Beg, Simon M., Parsons, Maddy, Toseland, Christopher P.

“…Myosin VI (MVI) has been found to be overexpressed in ovarian, breast and prostate cancers. Moreover, it has been shown to play a role in regulating cell…”
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Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function by Fili, Natalia, Hari-Gupta, Yukti, Aston, Bjork, dos Santos, Ália, Gough, Rosemarie E., Alamad, Bana, Wang, Lin, Martin-Fernandez, Marisa L., Toseland, Christopher P.

“…Myosin VI is involved in many cellular processes ranging from endocytosis to transcription. This multifunctional potential is achieved through alternative…”
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Organization of the extracellular portion of the macrophage galactose receptor: a trimeric cluster of simple binding sites for N-acetylgalactosamine by Jégouzo, Sabine A F, Quintero-Martínez, Adrián, Ouyang, Xiangyu, dos Santos, Ália, Taylor, Maureen E, Drickamer, Kurt

“…The properties of the human macrophage galactose receptor have been investigated. Specificity for N-acetylgalactosamine (GalNAc) residues with exposed 3- and…”
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Oligomerization domains in the glycan‐binding receptors DC‐SIGN and DC‐SIGNR: Sequence variation and stability differences by dos Santos, Ália, Hadjivasiliou, Andreas, Ossa, Felipe, Lim, Novandy K., Turgut, Aylin, Taylor, Maureen E., Drickamer, Kurt

“…Human dendritic cell‐specific intercellular adhesion molecule‐1 grabbing nonintegrin, DC‐SIGN, and the sinusoidal endothelial cell receptor DC‐SIGNR or L‐SIGN,…”
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High-throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays by dos Santos, Ália, Fili, Natalia, Pearson, David S., Hari-Gupta, Yukti, Toseland, Christopher P.

“…Mechanobiology is focused on how the physical forces and mechanical properties of proteins, cells, and tissues contribute to physiology and disease. Although…”
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Magnetic Tweezers in a Microplate Format by Dos Santos, Ália, Toseland, Christopher P

“…Mechanobiology describes how the physical forces and mechanical properties of biological material contribute to physiology and disease. Typically, these…”
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Comparative stability of Major Facilitator Superfamily transport proteins by Harris, Nicola J., Findlay, Heather E., Sanders, Michael R., Kedzierski, Mateusz, dos Santos, Ália, Booth, Paula J.

“…Membrane transporters are a vital class of proteins for which there is little available structural and thermodynamic information. The Major Facilitator…”
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Measuring Nuclear Organization of Proteins with STORM Imaging and Cluster Analysis by Dos Santos, Ália, Gough, Rosemarie E, Wang, Lin, Toseland, Christopher P

“…Super-resolution microscopy enables the high-precision localization of proteins. Therefore, it is possible to investigate the spatial organization of proteins…”
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Spatial and Physical Organisation of the Mammalian Nucleus by dos Santos, Ália

“…The nucleus is a dynamic and highly adaptable structure, essential for eukaryotic cell survival and function. As the largest and stiffest organelle in the…”
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Measuring Nuclear Mechanics with Atomic Force Microscopy by Dos Santos, Ália, Rehfeldt, Florian, Toseland, Christopher P

“…Atomic force microscopy is an ideal tool to map topography and mechanical properties of materials on the micro- and nanoscale. Here, we describe its…”
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Nuclear Ndp52 - a Putative Transcription Regulator by dos Santos, Alia, Wang, Lin, Toseland, Christopher P.

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Nuclear Myosin VI Stabilizes RNA Polymerase II in Transcription Factories by Hari Gupta, Yukti, Fili, Natalia, dos Santos, Alia, Chew, Teng-Leong, Aaron, Jesse, Wang, Lin, Toseland, Christopher P.

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Nuclear Myosin VI Regulates Estrogen Receptor Driven Gene Expression by Hari Gupta, Yukti, Fili, Natalia, dos Santos, Alia, Chew, Teng-Leong, Aaron, Jesse, Wang, Lin, Toseland, Christopher P.

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