Gabapentin, a Synthetic Analogue of Gamma Aminobutyric Acid, Reverses Systemic Acute Inflammation and Oxidative Stress in Mice

The aim of this study was to investigate the potential anti-inflammatory and anti-oxidant effects of gabapentin (GBP) in mice. The anti-inflammatory and anti-oxidant effects were evaluated using various mediators that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, proinflammato...

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Bibliographic Details
Published in:	Inflammation Vol. 37; no. 5; pp. 1826 - 1836
Main Authors:	Dias, Jordana Maia, de Brito, Tarcisio Vieira, de Aguiar Magalhães, Diva, da Silva Santos, Pammela Weryka, Batista, Jalles Arruda, do Nascimento Dias, Eulina Gabriela, de Barros Fernandes, Heliana, Damasceno, Samara Rodrigues Bonfim, Silva, Renan O., Aragão, Karoline S., Souza, Marcellus H. L. P., Medeiros, Jand-Venes R., Barbosa, André Luiz R.
Format:	Journal Article
Language:	English
Published:	Boston Springer US 01-10-2014 Springer Nature B.V
Subjects:	Acute Disease Amines - pharmacology Amines - therapeutic use Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biomedical and Life Sciences Biomedicine Cyclohexanecarboxylic Acids - pharmacology Cyclohexanecarboxylic Acids - therapeutic use Edema - chemically induced Edema - drug therapy Edema - metabolism gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - pharmacology gamma-Aminobutyric Acid - therapeutic use Immunology Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Internal Medicine Male Mice Oxidative Stress - drug effects Oxidative Stress - physiology Pathology Pharmacology/Toxicology Random Allocation Rheumatology anti-oxidant action gabapentin anti-inflammatory effect
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Summary:	The aim of this study was to investigate the potential anti-inflammatory and anti-oxidant effects of gabapentin (GBP) in mice. The anti-inflammatory and anti-oxidant effects were evaluated using various mediators that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, proinflammatory cytokine levels, glutathione (GSH) consumption, and malondialdehyde (MDA) production in mice. Pretreatment of mice with GBP (1 mg/kg) significantly reduced carrageenan or dextran-induced paw edema ( P < 0.05) when compared to vehicle group. Adding to this, GBP (1 mg/kg) significantly inhibited paw edema induced by histamine, serotonin, bradikinin, 48/80 compound, and prostaglandin E 2 . In the carrageenan-induced peritonitis model, GBP significantly decreased total and differential leukocyte counts and reduced the levels of MPO activity in the plantar tissue and IL-1β and TNF-α concentrations in the peritoneal exudate. The same dose of GBP also decreased the MDA concentration and increased the levels of GSH into the peritoneal fluid. In summary, our results demonstrated that GBP exhibited anti-inflammatory activity in mice by reducing the action of inflammatory mediators, neutrophil migration and proinflammatory cytokine levels, and anti-oxidant properties by decreasing the concentration of MDA and increasing the GSH content. These observations raise the possibility that GBP could be used to improve tissue resistance to damage during inflammatory conditions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0360-3997 1573-2576
DOI:	10.1007/s10753-014-9913-2