Search Results - "di Paola, Eugenio Donato"

Safety profile of biologic drugs for psoriasis in clinical practice: An Italian prospective pharmacovigilance study by Iannone, Luigi Francesco, Bennardo, Luigi, Palleria, Caterina, Roberti, Roberta, De Sarro, Caterina, Naturale, Maria Diana, Dastoli, Stefano, Donato, Luca, Manti, Antonia, Valenti, Giancarlo, D'Amico, Domenico, D'Attola, Santo, De Francesco, Adele Emanuela, Bosco, Vincenzo, Donato Di Paola, Eugenio, Nisticò, Steven Paul, Citraro, Rita, Russo, Emilio, De Sarro, Giovambattista

“…Psoriasis is an inflammatory and chronic skin disorder associated with physical and psychological burden impairing patients' quality of life. In the last…”
Get full text

Safety profiles of biologic agents for inflammatory bowel diseases: a prospective pharmacovigilance study in Southern Italy by Roberti, Roberta, Iannone, Luigi Francesco, Palleria, Caterina, De Sarro, Caterina, Spagnuolo, Rocco, Barbieri, Maria Antonietta, Vero, Ada, Manti, Antonia, Pisana, Valentina, Fries, Walter, Trifirò, Gianluca, Naturale, Maria Diana, Larussa, Tiziana, De Francesco, Adele Emanuela, Bosco, Vincenzo, Donato di Paola, Eugenio, Citraro, Rita, Luzza, Francesco, Bennardo, Luigi, Rodinò, Stefano, Doldo, Patrizia, Spina, Edoardo, Russo, Emilio, De Sarro, Giovambattista

“…Inflammatory bowel diseases (IBDs) are a public health issue with over 3.5 million patients in Europe, but the advent of several biologic agents has completely…”
Get full text

Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity by Russo, Emilio, Citraro, Rita, Davoli, Alessandro, Gallelli, Luca, Donato Di Paola, Eugenio, De Sarro, Giovambattista

“…Aripiprazole (APZ) is regarded as a first-line atypical antipsychotic used for the treatment of first and multiple episodes of schizophrenia to improve…”
Get full text

The Anticonvulsant Activity of a Flavonoid-Rich Extract from Orange Juice Involves both NMDA and GABA-Benzodiazepine Receptor Complexes by Citraro, Rita, Navarra, Michele, Leo, Antonio, Donato Di Paola, Eugenio, Santangelo, Ermenegildo, Lippiello, Pellegrino, Aiello, Rossana, Russo, Emilio, De Sarro, Giovambattista

“…The usage of dietary supplements and other natural products to treat neurological diseases has been growing over time, and accumulating evidence suggests that…”
Get full text

Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization by Conti, Paola, Pinto, Andrea, Tamborini, Lucia, Madsen, Ulf, Nielsen, Birgitte, Bräuner-Osborne, Hans, Hansen, Kasper B., Landucci, Elisa, Pellegrini-Giampietro, Domenico E., De Sarro, Giovambattista, Donato Di Paola, Eugenio, De Micheli, Carlo

“…The design and synthesis of new N1‐substituted 3‐carboxy‐ and 3‐phosphonopyrazoline and pyrazole amino acids that target the glutamate binding site of NMDA…”
Get full text

Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study by van Oosterom, Allan T, Judson, Ian, Verweij, Jaap, Stroobants, Sigrid, di Paola, Eugenio Donato, Dimitrijevic, Sasa, Martens, Marc, Webb, Andrew, Sciot, Raf, Van Glabbeke, Martine, Silberman, Sandra, Nielsen, Ole S

“…Gastrointestinal stromal tumours (GISTs) are rare tumours of the gastrointestinal tract characterised by cell-surface expression of the tyrosine kinase KIT…”
Get full text

The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment by Leo, Antonio, Citraro, Rita, Marra, Rosario, Palma, Ernesto, Paola, Eugenio Di Donato, Constanti, Andrew, De Sarro, Giovambattista, Russo, Emilio

“…It is currently known that erythrocytes are the major source of sphingosine 1-phosphate (S1P) in the body. S1P acts both extracellularly as a cellular mediator…”
Get more information

Exploring the effects of DPP-4 inhibitors on the kidney from the bench to clinical trials by Coppolino, Giuseppe, Leporini, Christian, Rivoli, Laura, Ursini, Francesco, di Paola, Eugenio Donato, Cernaro, Valeria, Arturi, Franco, Bolignano, Davide, Russo, Emilio, De Sarro, Giovambattista, Andreucci, Michele

“…[Display omitted] Dipeptidyl-peptidase-4 (DPP-4) inhibitors are a relatively new class of non-insulin glucose-lowering agents, belonging to the incretin…”
Get full text

Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study by Tassone, Pierfrancesco, Di Martino, Maria Teresa, Arbitrio, Mariamena, Fiorillo, Lucia, Staropoli, Nicoletta, Ciliberto, Domenico, Cordua, Alessia, Scionti, Francesca, Bertucci, Bernardo, Salvino, Angela, Lopreiato, Mariangela, Thunarf, Fredrik, Cuomo, Onofrio, Zito, Maria Cristina, De Fina, Maria Rosanna, Brescia, Amelia, Gualtieri, Simona, Riillo, Caterina, Manti, Francesco, Caracciolo, Daniele, Barbieri, Vito, Di Paola, Eugenio Donato, Di Francesco, Adele Emanuela, Tagliaferri, Pierosandro

“…We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-miR-221) with a full phosphorothioate (PS)-modified backbone. This agent…”
Get full text

Pazopanib a tyrosine kinase inhibitor with strong anti-angiogenetic activity: A new treatment for metastatic soft tissue sarcoma by Ranieri, Girolamo, Mammì, Maria, Donato Di Paola, Eugenio, Russo, Emilio, Gallelli, Luca, Citraro, Rita, Gadaleta, Cosmo Damiano, Marech, Ilaria, Ammendola, Michele, De Sarro, Giovambattista

“…Abstract Soft tissue sarcomas (STS) are rare tumors with mesenchymal origin, accounting for 1% of all human cancer. Local control of STS can be obtained…”
Get full text

Pharmacodynamic potentiation of antiepileptic drugs’ effects by some HMG-CoA reductase inhibitors against audiogenic seizures in DBA/2 mice by Russo, Emilio, Donato di Paola, Eugenio, Gareri, Pietro, Siniscalchi, Antonio, Labate, Angelo, Gallelli, Luca, Citraro, Rita, De Sarro, Giovambattista

“…It is known that the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are effective in both the primary and the secondary…”
Get full text

Perampanel chronic treatment does not induce tolerance and decreases tolerance to clobazam in genetically epilepsy prone rats by Citraro, Rita, De Sarro, Caterina, Leo, Antonio, Donato di Paola, Eugenio, Palma, Ernesto, Russo, Emilio, De Sarro, Giovambattista

“…•Perampanel is efficacious against audiogenic seizures in GEPR-9 s rats.•Perampanel effects are maintained over 10 weeks of treatment.•Perampanel…”
Get full text

Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice by De Sarro, Giovambattista, Russo, Emilio, Ferreri, Guido, Giuseppe, Bruzzese, Flocco, Maria Antonietta, Di Paola, Eugenio Donato, De Sarro, Angela

“…In the present study, the susceptibility of knockout interleukin-6 (IL-6 −/−) mice to various convulsant stimuli has been evaluated and compared with other…”
Get full text

Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice by De Sarro, Giovambattista, Paola, Eugenio Donato Di, Gratteri, Santo, Gareri, Pietro, Rispoli, Vincenzo, Siniscalchi, Antonio, Tripepi, Giovanni, Gallelli, Luca, Citraro, Rita, Russo, Emilio

“…The renin–angiotensin system (RAS) exists in the brain and it may be involved in pathogenesis of neurological and psychiatric disorders including seizures. The…”
Get full text

Imatinib pharmacokinetics in patients with gastrointestinal stromal tumour: a retrospective population pharmacokinetic study over time. EORTC Soft Tissue and Bone Sarcoma Group by JUDSON, Ian, PEIMING MA, VAN OOSTEROM, Allan, BIN PENG, VERWEIJ, Jaap, RACINE, Amy, DI PAOLA, Eugenio Donato, VAN GLABBEKE, Martine, DIMITRIJEVIC, Sasa, SCURR, Michelle, DUMEZ, Herlinde

“…Imatinib pharmacokinetics (PK) may be affected by a number of factors that are related to the disease being treated and to the response of that disease to…”
Get full text

Update of phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: a report of the EORTC Soft Tissue and Bone Sarcoma Group by van Oosterom, Allan T., Judson, Ian R., Verweij, Jaap, Stroobants, Sigrid, Dumez, Herlinde, Donato di Paola, Eugenio, Sciot, Raf, Van Glabbeke, Martine, Dimitrijevic, Sasa, Nielsen, Ole S.

“…In a phase I study conducted by the EORTC Soft Tissue and Bone Sarcoma Group, 40 patients with advanced soft tissue sarcomas, most of whom had gastrointestinal…”
Get full text

Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice by De Sarro, Giovambattista, Ibbadu, Guido Ferreri, Marra, Rosario, Rotiroti, Domenicantonio, Loiacono, Antonella, Donato Di Paola, Eugenio, Russo, Emilio

“…In the present study, the susceptibility of the mdx mouse, a dystrophin-deficient genetic model of Duchenne muscular dystrophy (DMD), to various convulsant…”
Get full text

Pharmacovigilance in pharmaceutical companies: An overview by Mammì, Maria, Citraro, Rita, Torcasio, Giovanni, Cusato, Gennaro, Palleria, Caterina, di Paola, Eugenio Donato

“…Pharmacovigilance is responsible for monitoring the safety of medicines in normal clinical use and during clinical trials. In the light of the experience…”
Get full text

Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy by Russo, Emilio, Citraro, Rita, Fazio, Salvatore De, Marra, Rosario, Gitto, Rosaria, Chimirri, Alba, De Sarro, Giovambattista, Paola, Eugenio Donato Di

“…Abstract N -Acetyl-1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (THIQ-10c) is a noncompetitive…”
Get full text

Influence of levetiracetam on the anticonvulsant efficacy of conventional antiepileptic drugs against audiogenic seizures in DBA/2 mice by Donato Di Paola, Eugenio, Gareri, Pietro, Davoli, Alessandro, Gratteri, Santo, Scicchitano, Francesca, Naccari, Clara, De Sarro, Giovambattista

“…Summary Levetiracetam (LEV, [S]-alpha-ethyl-2-oxo-1-pyrrolidine acetamide) is a new antiepileptic that has been used as adjunctive therapy to treat patients…”
Get full text