Search Results - "di Guilmi, Mariano N"

Enhancement of the Medial Olivocochlear System Prevents Hidden Hearing Loss by Boero, Luis E, Castagna, Valeria C, Di Guilmi, Mariano N, Goutman, Juan D, Elgoyhen, Ana Belén, Gómez-Casati, María Eugenia

“…Cochlear synaptopathy produced by exposure to noise levels that cause only transient auditory threshold elevations is a condition that affects many people and…”
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Volume electron microscopy reveals age-related circuit remodeling in the auditory brainstem by Chequer Charan, Daniela, Hua, Yunfeng, Wang, Haoyu, Huang, Wenqing, Wang, Fangfang, Elgoyhen, Ana Belén, Boergens, Kevin M, Di Guilmi, Mariano N

“…The medial nucleus of the trapezoid body (MNTB) is an integral component of the auditory brainstem circuitry involved in sound localization. The giant…”
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Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i by Di Guilmi, Mariano N, Wang, Tiantian, Inchauspe, Carlota Gonzalez, Forsythe, Ian D, Ferrari, Michel D, van den Maagdenberg, Arn M J M, Borst, J Gerard G, Uchitel, Osvaldo D

“…Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated CaV2.1 channels, are associated with familial hemiplegic migraine…”
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Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse by González-Inchauspe, Carlota, Urbano, Francisco J, Di Guilmi, Mariano N, Uchitel, Osvaldo D

“…Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. We found that these channels can be…”
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Acute modulation of calcium currents and synaptic transmission by gabapentinoids by Uchitel, Osvaldo D., Di Guilmi, Mariano N., Urbano, Francisco J., Gonzalez-Inchauspe, Carlota

“…Gabapentin and pregabalin are anticonvulsant drugs that are extensively used for the treatment of several neurological and psychiatric disorders…”
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Deletion of dopamine D₂ receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes by Tomasella, Eugenia, Bechelli, Lucila, Ogando, Mora Belén, Mininni, Camilo, Di Guilmi, Mariano N., De Fino, Fernanda, Zanutto, Silvano, Elgoyhen, Ana Belén, Marin-Burgin, Antonia, Gelman, Diego M.

“…Excessive dopamine neurotransmission underlies psychotic episodes as observed in patients with some types of bipolar disorder and schizophrenia. The…”
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Strengthening of the Efferent Olivocochlear System Leads to Synaptic Dysfunction and Tonotopy Disruption of a Central Auditory Nucleus by Di Guilmi, Mariano N, Boero, Luis E, Castagna, Valeria C, Rodríguez-Contreras, Adrián, Wedemeyer, Carolina, Gómez-Casati, María Eugenia, Elgoyhen, Ana Belén

“…The auditory system in many mammals is immature at birth but precisely organized in adults. Spontaneous activity in the inner ear plays a critical role in…”
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A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity by Wedemeyer, Carolina, Vattino, Lucas G, Moglie, Marcelo J, Ballestero, Jimena, Maison, Stéphane F, Di Guilmi, Mariano N, Taranda, Julian, Liberman, M Charles, Fuchs, Paul A, Katz, Eleonora, Elgoyhen, Ana Belén

“…Gain control of the auditory system operates at multiple levels. Cholinergic medial olivocochlear (MOC) fibers originate in the brainstem and make synaptic…”
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Deletion of dopamine D 2 receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes by Tomasella, Eugenia, Bechelli, Lucila, Ogando, Mora Belén, Mininni, Camilo, Di Guilmi, Mariano N, De Fino, Fernanda, Zanutto, Silvano, Elgoyhen, Ana Belén, Marin-Burgin, Antonia, Gelman, Diego M

“…Excessive dopamine neurotransmission underlies psychotic episodes as observed in patients with some types of bipolar disorder and schizophrenia. The…”
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Pregabalin modulation of neurotransmitter release is mediated by change in intrinsic activation/inactivation properties of ca(v)2.1 calcium channels by Di Guilmi, Mariano N, Urbano, Francisco J, Inchauspe, Carlota Gonzalez, Uchitel, Osvaldo D

“…In this work, we studied the effects of the anticonvulsant and analgesic drug pregabalin (PGB) on excitatory postsynaptic currents (EPSCs) at principal neurons…”
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Acute effects of pregabalin on the function and cellular distribution of Ca(V)2.1 in HEK293t cells by Weissmann, Carina, Di Guilmi, Mariano N, Urbano, Francisco J, Uchitel, Osvaldo D

“…We established a cell model to study the acute effects of pregabalin (PGB), a drug widely used in epilepsy and neuropathic pain, on voltage gated Ca(V)2.1…”
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Presynaptic CaV2.1 calcium channels carrying familial hemiplegic migraine mutation R192Q allow faster recovery from synaptic depression in mouse calyx of Held by Inchauspe, Carlota González, Urbano, Francisco J, Di Guilmi, Mariano N, Ferrari, Michel D, van den Maagdenberg, Arn M J M, Forsythe, Ian D, Uchitel, Osvaldo D

“…Ca(V)2.1 Ca(2+) channels have a dominant and specific role in initiating fast synaptic transmission at central excitatory synapses, through a close association…”
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Gain of function in FHM-1 Cav2.1 knock-in mice is related to the shape of the action potential by Inchauspe, Carlota González, Urbano, Francisco J, Di Guilmi, Mariano N, Forsythe, Ian D, Ferrari, Michel D, van den Maagdenberg, Arn M J M, Uchitel, Osvaldo D

“…Familial hemiplegic migraine type-1 FHM-1 is caused by missense mutations in the CACNA1A gene that encodes the alpha(1A) pore-forming subunit of Ca(V)2.1…”
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Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice by Inchauspe, Carlota González, Pilati, Nadia, Di Guilmi, Mariano N., Urbano, Francisco J., Ferrari, Michel D., van den Maagdenberg, Arn M.J.M., Forsythe, Ian D., Uchitel, Osvaldo D.

“…CaV2.1 Ca2+ channels play a key role in triggering neurotransmitter release and mediating synaptic transmission. Familial hemiplegic migraine type-1 (FHM-1) is…”
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Calcium channels and synaptic transmission in familial hemiplegic migraine type 1 animal models by Uchitel, Osvaldo D., González Inchauspe, Carlota, Di Guilmi, Mariano N.

“…One of the outstanding developments in clinical neurology has been the identification of ion channel mutations as the origin of a wide variety of inherited…”
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CaV2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis by Uchitel, Osvaldo D., Inchauspe, Carlota González, Urbano, Francisco J., Di Guilmi, Mariano N.

“…► Mutations in CaV2.1 Ca2+ channels cause familial hemiplegic migraine type 1 (FHM1). ► CaV2.1 channels with the human FHM1 mutations activate at more…”
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Deletion of dopamine D^sub 2^ receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes by Tomasella, Eugenia, Bechelli, Lucila, Ogando, Mora Belén, Mininni, Camilo, di Guilmi, Mariano N, de Fino, Fernanda, Zanutto, Silvano, Elgoyhen, Ana Belén, Marin-Burgin, Antonia, Gelman, Diego M

“…Excessive dopamine neurotransmission underlies psychotic episodes as observed in patients with some types of bipolar disorder and schizophrenia. The…”
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Acute effects of pregabalin on the function and cellular distribution of CaV2.1 in HEK293t cells by Weissmann, Carina, Di Guilmi, Mariano N., Urbano, Francisco J., Uchitel, Osvaldo D.

“…► PGB induced acute changes in localization of CaV2.1 channels in a HEK cell model. ► PGB-induced CaV2.1 channels internalization correlates with a reversible…”
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Synaptic Gain-of-Function Effects of Mutant Ca v 2.1 Channels in a Mouse Model of Familial Hemiplegic Migraine Are Due to Increased Basal [Ca 2+ ] i by Di Guilmi, Mariano N., Wang, Tiantian, Inchauspe, Carlota Gonzalez, Forsythe, Ian D., Ferrari, Michel D., van den Maagdenberg, Arn M.J.M., Borst, J. Gerard G., Uchitel, Osvaldo D.

“…Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated Ca V 2.1 channels, are associated with familial hemiplegic migraine…”
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Synaptic Gain-of-Function Effects of Mutant Ca sub(v) 2.1 Channels in a Mouse Model of Familial Hemiplegic Migraine Are Due to Increased Basal [Ca super(2+)] sub(i) by Di Guilmi, Mariano N, Wang, Tiantian, Inchauspe, Carlota Gonzalez, sythe, Ian D, Ferrari, Michel D, van den Maagdenberg, Arn MJM, Borst, J Gerard G, Uchitel, Osvaldo D

“…Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated Ca sub(V) 2.1 channels, are associated with familial hemiplegic…”
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