Search Results - "den Hamer, Anniek"

Small‐Molecule‐Induced and Cooperative Enzyme Assembly on a 14‐3‐3 Scaffold by den Hamer, Anniek, Lemmens, Lenne J. M., Nijenhuis, Minke A. D., Ottmann, Christian, Merkx, Maarten, de Greef, Tom F. A., Brunsveld, Luc

“…Scaffold proteins regulate cell signalling by promoting the proximity of putative interaction partners. Although they are frequently applied in cellular…”
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Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome by Rosier, Bas J. H. M., Markvoort, Albert J., Gumí Audenis, Berta, Roodhuizen, Job A. L., den Hamer, Anniek, Brunsveld, Luc, de Greef, Tom F. A.

“…Living cells regulate key cellular processes by spatial organization of catalytically active proteins in higher-order signalling complexes. These act as…”
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Bright Bioluminescent BRET Sensor Proteins for Measuring Intracellular Caspase Activity by den Hamer, Anniek, Dierickx, Pieterjan, Arts, Remco, de Vries, Joost S. P. M, Brunsveld, Luc, Merkx, Maarten

“…FRET-based caspase activity probes have become important tools to monitor apoptotic cell signaling. However, their dependence on external illumination is…”
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Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation by Xu, Xiaolu, Lemmens, Lenne J. M., den Hamer, Anniek, Merkx, Maarten, Ottmann, Christian, Brunsveld, Luc

“…Phosphorylation is a key regulation event in cellular signaling. Sensing the underlying kinase activity is of crucial importance for its fundamental…”
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Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation† †Electronic supplementary information (ESI) available: Experimental details, supporting figures and supporting discussion. See DOI: 10.1039/d0sc00074d by Xu, Xiaolu, Lemmens, Lenne J. M., den Hamer, Anniek, Merkx, Maarten, Ottmann, Christian, Brunsveld, Luc

“…Phosphorylation is a key regulation event in cellular signaling. To sense the underlying kinase activity, we engineered modular and easy adaptable serine…”
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Improved Immunoassay Sensitivity in Serum as a Result of Polymer-Entrapped Quantum Dots: ‘Papaya Particles’ by Ranzoni, Andrea, den Hamer, Anniek, Karoli, Tomislav, Buechler, Joseph, Cooper, Matthew. A

“…Fluorescent labels are widely employed in biomarker quantification and diagnostics, however they possess narrow Stokes shifts and can photobleach, limiting…”
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Protease-Activatable Scaffold Proteins as Versatile Molecular Hubs in Synthetic Signaling Networks by Aper, Stijn J. A, den Hamer, Anniek, Wouters, Simone F. A, Lemmens, Lenne J. M, Ottmann, Christian, Brunsveld, Luc, Merkx, Maarten

“…Protease signaling and scaffold-induced control of protein–protein interactions represent two important mechanisms for intracellular signaling. Here we report…”
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Current techniques for management of transverse displaced olecranon fractures by den Hamer, Anniek, Heusinkveld, Maarten, Traa, Willeke, Oomen, Pim, Oliva, Francesco, Del Buono, Angelo, Maffulli, Nicola

“…displaced transverse fractures of the olecranon are the most common fractures occurring in the elbow in adults that requires operative intervention. a…”
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Treatment of transverse patellar fractures: a comparison between metallic and non-metallic implants by Heusinkveld, Maarten H G, den Hamer, Anniek, Traa, Willeke A, Oomen, Pim J A, Maffulli, Nicola

“…Several methods of transverse patellar fixation have been described. This study compares the clinical outcome and the occurrence of complications of various…”
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Biomechanical studies on transverse olecranon and patellar fractures: a systematic review with the development of a new scoring method by Traa, Willeke A, Oomen, Pim J A, den Hamer, Anniek, Heusinkveld, Maarten H G, Maffulli, Nicola

“…Several methods of transverse patellar and olecranon fixation have been described. This article compares biomechanical studies of various fixation methods…”
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Modular bioengineered kinase sensors scaffold protein-mediated split-luciferase complementation by Xu, Xiaolu, Lemmens, Lenne J. M, den Hamer, Anniek, Merkx, Maarten, Ottmann, Christian, Brunsveld, Luc

“…Phosphorylation is a key regulation event in cellular signaling. Sensing the underlying kinase activity is of crucial importance for its fundamental…”
Get full text