Search Results - "den Boon, Johan A."

MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins by Sengupta, Srikumar, den Boon, Johan A, Chen, I. How, Newton, Michael A, Stanhope, Stephen A, Cheng, Yu-Juen, Chen, Chien-Jen, Hildesheim, Allan, Sugden, Bill, Ahlquist, Paul

“…Using highly sensitive microarray-based procedures, we identified eight microRNAs (miRNAs) showing robust differential expression between 31…”
Get full text

Cryo-electron tomography reveals novel features of a viral RNA replication compartment by Ertel, Kenneth J, Benefield, Desirée, Castaño-Diez, Daniel, Pennington, Janice G, Horswill, Mark, den Boon, Johan A, Otegui, Marisa S, Ahlquist, Paul

“…Positive-strand RNA viruses, the largest genetic class of viruses, include numerous important pathogens such as Zika virus. These viruses replicate their RNA…”
Get full text

Organelle-Like Membrane Compartmentalization of Positive-Strand RNA Virus Replication Factories by DEN BOON, Johan A, AHLQUIST, Paul

“…Positive-strand RNA virus genome replication is invariably associated with extensively rearranged intracellular membranes. Recent biochemical and electron…”
Get full text

Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling by den Boon, Johan A., Pyeon, Dohun, Wang, Sophia S., Horswill, Mark, Schiffman, Mark, Sherman, Mark, Zuna, Rosemary E., Wang, Zhishi, Hewitt, Stephen M., Pearson, Rachel, Schott, Meghan, Chung, Lisa, He, Qiuling, Lambert, Paul, Walker, Joan, Newton, Michael A., Wentzensen, Nicolas, Ahlquist, Paul

“…To study the multistep process of cervical cancer development, we analyzed 128 frozen cervical samples spanning normalcy, increasingly severe cervical…”
Get full text

Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen by Spurgeon, Megan E., den Boon, Johan A., Horswill, Mark, Barthakur, Sonalee, Forouzan, Omid, Rader, Janet S., Beebe, David J., Roopra, Avtar, Ahlquist, Paul, Lambert, Paul F.

“…High-risk human papillomaviruses (HPVs) infect epithelial cells and are causally associated with cervical cancer, but HPV infection is not sufficient for…”
Get full text

Crowning Touches in Positive-Strand RNA Virus Genome Replication Complex Structure and Function by Nishikiori, Masaki, den Boon, Johan A, Unchwaniwala, Nuruddin, Ahlquist, Paul

“…Positive-strand RNA viruses, the largest genetic class of eukaryotic viruses, include coronaviruses and many other established and emerging pathogens. A major…”
Get full text

Key aspects of papillomavirus infection influence the host cervicovaginal microbiome in a preclinical murine papillomavirus (MmuPV1) infection model by Spurgeon, Megan E, Townsend, Elizabeth C, Blaine-Sauer, Simon, McGregor, Stephanie M, Horswill, Mark, den Boon, Johan A, Ahlquist, Paul, Kalan, Lindsay, Lambert, Paul F

“…Human papillomaviruses (HPVs) are the most common sexually transmitted infection in the United States and are a major etiological agent of cancers in the…”
Get full text

Multifunctional Protein A Is the Only Viral Protein Required for Nodavirus RNA Replication Crown Formation by den Boon, Johan A, Zhan, Hong, Unchwaniwala, Nuruddin, Horswill, Mark, Slavik, Kailey, Pennington, Janice, Navine, Amanda, Ahlquist, Paul

“…Positive-strand RNA virus RNA genome replication occurs in membrane-associated RNA replication complexes (RCs). Nodavirus RCs are outer mitochondrial membrane…”
Get full text

Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers by PYEON, Dohun, NEWTON, Michael A, KELSEY, Karl T, TUREK, Lubomir P, AHLQUIST, Paul, LAMBERT, Paul F, DEN BOON, Johan A, SENGUPTA, Srikumar, MARSIT, Carmen J, WOODWORTH, Craig D, CONNOR, Joseph P, HAUGEN, Thomas H, SMITH, Elaine M

“…Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30% of head and neck cancers (HNC), and other cancers. Because HNCs also…”
Get full text

Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancer by Bodelon, Clara, Vinokurova, Svetlana, Sampson, Joshua N, den Boon, Johan A, Walker, Joan L, Horswill, Mark A, Korthauer, Keegan, Schiffman, Mark, Sherman, Mark E, Zuna, Rosemary E, Mitchell, Jason, Zhang, Xijun, Boland, Joseph F, Chaturvedi, Anil K, Dunn, S Terence, Newton, Michael A, Ahlquist, Paul, Wang, Sophia S, Wentzensen, Nicolas

“…The relationship between chromosomal instability and integration of the human papillomavirus (HPV) DNA into the host genome is not well understood. We found…”
Get full text

Random-Set Methods Identify Distinct Aspects of the Enrichment Signal in Gene-Set Analysis by Newton, Michael A., Quintana, Fernando A., Johan A. den Boon, Srikumar Sengupta, Ahlquist, Paul

“…A prespecified set of genes may be enriched, to varying degrees, for genes that have altered expression levels relative to two or more states of a cell…”
Get full text

An amphipathic alpha-helix controls multiple roles of brome mosaic virus protein 1a in RNA replication complex assembly and function by Liu, Ling, Westler, William M, den Boon, Johan A, Wang, Xiaofeng, Diaz, Arturo, Steinberg, H Adam, Ahlquist, Paul

“…Brome mosaic virus (BMV) protein 1a has multiple key roles in viral RNA replication. 1a localizes to perinuclear endoplasmic reticulum (ER) membranes as a…”
Get full text

Intersection of the Multivesicular Body Pathway and Lipid Homeostasis in RNA Replication by a Positive-Strand RNA Virus by Wang, Xiaofeng, Diaz, Arturo, Hao, Linhui, Gancarz, Brandi, den Boon, Johan A, Ahlquist, Paul

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

An infectious arterivirus cDNA clone: identification of a replicase point mutation that abolishes discontinuous mRNA transcription by Dinten, L.C. van (Leiden Univ., Leiden, Netherlands.), Boon, J.A. den, Wassenaar, A.L.M, Spaan, W.J.M, Snijder, E.J

“…Equine arteritis virus (EAV) is a positive-strand RNA virus that uses a discontinuous transcription mechanism to generate a nested set of six subgenomic mRNAs…”
Get full text

Positive-strand RNA virus genome replication organelles: structure, assembly, control by den Boon, Johan A., Nishikiori, Masaki, Zhan, Hong, Ahlquist, Paul

“…Many aspects of the life cycle and genetics of (+)RNA viruses are directed by their genome replication organelles (ROs), which form as spherular membrane…”
Get full text

Cytoplasmic viral replication complexes by den Boon, Johan A, Diaz, Arturo, Ahlquist, Paul

“…Many viruses that replicate in the cytoplasm compartmentalize their genome replication and transcription in organelle-like structures that enhance replication…”
Get full text

Genes Involved in DNA Repair and Nitrosamine Metabolism and Those Located on Chromosome 14q32 Are Dysregulated in Nasopharyngeal Carcinoma by DODD, Lori E, SENGUPTA, Srikumar, AHLQUIST, Paul, HILDESHEIM, Allan, CHEN, I-How, DEN BOON, Johan A, CHENG, Yu-Juen, WESTRA, William, NEWTON, Michael A, MITTL, Beth F, MCSHANE, Lisa, CHEN, Chien-Jen

“…Polymorphisms in nitrosamine metabolism, DNA repair, and immune response genes have been associated with nasopharyngeal carcinoma (NPC). Studies have suggested…”
Get full text

Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication by Unchwaniwala, Nuruddin, Zhan, Hong, Pennington, Janice, Horswill, Mark, den Boon, Johan A., Ahlquist, Paul

“…For positive-strand RNA [(+)RNA] viruses, the major target for antiviral therapies is genomic RNA replication, which occurs at poorly understood membrane-bound…”
Get full text

Nodavirus RNA replication crown architecture reveals proto-crown precursor and viral protein A conformational switching by Zhan, Hong, Unchwaniwala, Nuruddin, Rebolledo-Viveros, Andrea, Pennington, Janice, Horswill, Mark, Broadberry, Roma, Myers, Jonathan, den Boon, Johan A, Grant, Timothy, Ahlquist, Paul

“…Positive-strand RNA viruses replicate their genomes in virus-induced membrane vesicles, and the resulting RNA replication complexes are a major target for…”
Get full text

Cryo-electron microscopy of nodavirus RNA replication organelles illuminates positive-strand RNA virus genome replication by Unchwaniwala, Nuruddin, Zhan, Hong, den Boon, Johan A, Ahlquist, Paul

“…The nodavirus flock house virus recently provided a well-characterized model for the first cryo-electron microscope tomography of membrane-bound,…”
Get full text