Search Results - "den Hertog, Jeroen"

Evolution-Informed Discovery of the Naphthalenone Biosynthetic Pathway in Fungi by Mosunova, Olga V, Navarro-Muñoz, Jorge C, Haksar, Diksha, van Neer, Jacq, Hoeksma, Jelmer, den Hertog, Jeroen, Collemare, Jérôme

“…Fungi produce a wide diversity of secondary metabolites with interesting biological activities for the health, industrial, and agricultural sectors. While…”
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Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects by Solman, Maja, Blokzijl-Franke, Sasja, Piques, Florian, Yan, Chuan, Yang, Qiqi, Strullu, Marion, Kamel, Sarah M, Ak, Pakize, Bakkers, Jeroen, Langenau, David M, Cavé, Hélène, den Hertog, Jeroen

“…Gain-of-function mutations in the protein-tyrosine phosphatase SHP2 are the most frequently occurring mutations in sporadic juvenile myelomonocytic leukemia…”
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In-depth Qualitative and Quantitative Profiling of Tyrosine Phosphorylation Using a Combination of Phosphopeptide Immunoaffinity Purification and Stable Isotope Dimethyl Labeling by Boersema, Paul J., Foong, Leong Yan, Ding, Vanessa M.Y., Lemeer, Simone, van Breukelen, Bas, Philp, Robin, Boekhorst, Jos, Snel, Berend, den Hertog, Jeroen, Choo, Andre B.H., Heck, Albert J.R.

“…Several mass spectrometry-based assays have emerged for the quantitative profiling of cellular tyrosine phosphorylation. Ideally, these methods should reveal…”
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Berkchaetoazaphilone B has antimicrobial activity and affects energy metabolism by Ouyang, Xudong, Hoeksma, Jelmer, van der Velden, Gisela, Beenker, Wouter A. G., van Triest, Maria H., Burgering, Boudewijn M. T., den Hertog, Jeroen

“…Antimicrobial resistance has become one of the major threats to human health. Therefore, there is a strong need for novel antimicrobials with new mechanisms of…”
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Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects by Jopling, Chris, van Geemen, Daphne, den Hertog, Jeroen

“…Shp2 is a cytoplasmic protein-tyrosine phosphatase that is essential for normal development. Activating and inactivating mutations have been identified in…”
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Laminin-α4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells by KNOLL, Ralph, POSTEL, Ruben, KUBE, Dieter, KNOLL, Gudrun, SCHÄFER, Katrin, HAYASHI, Takeharu, HOLM, Torbjorn, KIMURA, Akinori, SCHORK, Nicholas, MOHAMMAD REZA TOLIAT, NÜRNBERG, Peter, SCHULTHEISS, Heinz-Peter, JIANMING WANG, SCHAPER, Wolfgang, SCHAPER, Jutta, BOS, Erik, DEN HERTOG, Jeroen, VAN EEDEN, Fredericus J. M, PETERS, Peter J, HASENFUSS, Gerd, CHIEN, Kenneth R, BAKKERS, Jeroen, KRÄTZNER, Ralph, HENNECKE, Gerrit, VACARU, Andrei M, VAKEEL, Padmanabhan, SCHUBERT, Cornelia, MURTHY, Kenton, RANA, Brinda K

“…Background— Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying…”
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Distinct and overlapping functions of ptpn11 genes in Zebrafish development by Bonetti, Monica, Rodriguez-Martinez, Virginia, Paardekooper Overman, Jeroen, Overvoorde, John, van Eekelen, Mark, Jopling, Chris, Hertog, Jeroen den

“…The PTPN11 (protein-tyrosine phosphatase, non-receptor type 11) gene encodes SHP2, a cytoplasmic PTP that is essential for vertebrate development. Mutations in…”
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A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development by Ciarlo, Christie, Kaufman, Charles K, Kinikoglu, Beste, Michael, Jonathan, Yang, Song, D Amato, Christopher, Blokzijl-Franke, Sasja, den Hertog, Jeroen, Schlaeger, Thorsten M, Zhou, Yi, Liao, Eric, Zon, Leonard I

“…The neural crest is a dynamic progenitor cell population that arises at the border of neural and non-neural ectoderm. The inductive roles of FGF, Wnt, and BMP…”
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Protein tyrosine phosphatases: regulatory mechanisms by Hertog, Jeroen den, Östman, Arne, Böhmer, Frank-D

“…Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted…”
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Phosphoproteomics-mediated identification of Fer kinase as a target of mutant Shp2 in Noonan and LEOPARD syndrome by Paardekooper Overman, Jeroen, Preisinger, Christian, Prummel, Karin, Bonetti, Monica, Giansanti, Piero, Heck, Albert, den Hertog, Jeroen

“…Noonan syndrome (NS) and LEOPARD syndrome (LS) cause congenital afflictions such as short stature, hypertelorism and heart defects. More than 50% of NS and…”
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Online Automated in Vivo Zebrafish Phosphoproteomics: From Large-Scale Analysis Down to a Single Embryo by Lemeer, Simone, Pinkse, Martijn W. H, Mohammed, Shabaz, van Breukelen, Bas, den Hertog, Jeroen, Slijper, Monique, Heck, Albert J. R

“…In the developing embryo, as in many other biological processes, complex signaling pathways are under tight control of reversible phosphorylation, guiding cell…”
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Knocking down low molecular weight protein tyrosine phosphatase (LMW-PTP) reverts chemoresistance through inactivation of Src and Bcr-Abl proteins by Ferreira, Paula A, Ruela-de-Sousa, Roberta R, Queiroz, Karla C S, Souza, Ana Carolina S, Milani, Renato, Pilli, Ronaldo Aloise, Peppelenbosch, Maikel P, den Hertog, Jeroen, Ferreira, Carmen V

“…The development of multidrug resistance (MDR) limits the efficacy of continuous chemotherapeutic treatment in chronic myelogenous leukemia (CML). Low molecular…”
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Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects by Runtuwene, Vincent, van Eekelen, Mark, Overvoorde, John, Rehmann, Holger, Yntema, Helger G, Nillesen, Willy M, van Haeringen, Arie, van der Burgt, Ineke, Burgering, Boudewijn, den Hertog, Jeroen

“…Noonan syndrome is a relatively common developmental disorder that is characterized by reduced growth, wide-set eyes and congenital heart defects. Noonan…”
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Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development by Stumpf, Miriam, den Hertog, Jeroen

“…The lipid- and protein phosphatase PTEN is one of the most frequently mutated tumor suppressor genes in human cancers and many mutations found in tumor samples…”
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Protein tyrosine phosphatases in health and disease by Hendriks, Wiljan J. A. J, Elson, Ari, Harroch, Sheila, Pulido, Rafael, Stoker, Andrew, den Hertog, Jeroen

“…Protein tyrosine phosphatases (PTPs) represent a super‐family of enzymes that play essential roles in normal development and physiology. In this review, we…”
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Gregatins, a Group of Related Fungal Secondary Metabolites, Inhibit Aspects of Quorum Sensing in Gram-Negative Bacteria by Beenker, Wouter A. G., Hoeksma, Jelmer, den Hertog, Jeroen

“…Quorum sensing (QS) is a process that regulates gene expression based on cell density. In bacteria, QS facilitates collaboration and controls a large number of…”
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Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells by Blokzijl-Franke, Sasja, Ponsioen, Bas, Schulte-Merker, Stefan, Herbomel, Philippe, Kissa, Karima, Choorapoikayil, Suma, den Hertog, Jeroen

“…Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the…”
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Studying Protein-Tyrosine Phosphatases in Zebrafish by Hale, Alexander James, den Hertog, Jeroen

“…Protein-tyrosine phosphatases (PTPs) are a large family of signal transduction regulators that have an essential role in normal development and physiology…”
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Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis by Stumpf, Miriam, Blokzijl-Franke, Sasja, den Hertog, Jeroen

“…The lipid- and protein phosphatase PTEN is an essential tumor suppressor that is highly conserved among all higher eukaryotes. As an antagonist of the PI3K/Akt…”
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Harzianic acid exerts antimicrobial activity against Gram-positive bacteria and targets the cell membrane by Ouyang, Xudong, Hoeksma, Jelmer, Beenker, Wouter A G, van der Beek, Samantha, den Hertog, Jeroen

“…The thermophilic fungus is a saprobe that is commonly isolated from soil. Here, we identified a Gram-positive bacteria-selective antimicrobial secondary…”
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