Search Results - "del Zoppo, GJ"

Thrombolysis for acute ischaemic stroke by Wardlaw, Joanna M, Murray, Veronica, Berge, Eivind, del Zoppo, Gregory J

“…Most strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before major brain…”
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Thrombolysis for acute ischaemic stroke by Wardlaw, Joanna M, Murray, Veronica, Berge, Eivind, Del Zoppo, Gregory J

“…The majority of strokes are due to blockage of an artery in the brain by a blood clot. Prompt treatment with thrombolytic drugs can restore blood flow before…”
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Alteplase for ischaemic stroke—responses by Wardlaw, Joanna M, Murray, Veronica, Berge, Eivind, Del Zoppo, Gregory J

“…Roger Shinton is worried about the adequacy of blinding of treatment allocation in the trials. In the earlier Cochrane review, we noted that saline was not an…”
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Thrombolysis for Acute Ischemic Stroke, Update August 2014 by Wardlaw, Joanna M., Murray, Veronica, Berge, Eivind, del Zoppo, Gregory J.

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PROACT: A Phase II Randomized Trial of Recombinant Pro-Urokinase by Direct Arterial Delivery in Acute Middle Cerebral Artery Stroke by del Zoppo, Gregory J., Higashida, Randall T., Furlan, Anthony J., Pessin, Michael S., Rowley, Howard A., Gent, Michael

“…Background and Purpose —To test the safety and recanalization efficacy of intra-arterial local delivery of plasminogen activators in acute ischemic stroke, a…”
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Thrombolysis for Acute Ischemic Stroke by Wardlaw, Joanna M., Murray, Veronica, Berge, Eivind, del Zoppo, Gregory J.

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In stroke, complement will get you nowhere by del Zoppo, Gregory J

“…The complement cascade has been proposed as another participant in the inflammatory events leading to neural tissue damage after stroke. But only time, and…”
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Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials by Emberson, Jonathan, PhD, Lees, Kennedy R, Prof, Lyden, Patrick, Prof, Blackwell, Lisa, BSc, Albers, Gregory, Prof, Bluhmki, Erich, Prof, Brott, Thomas, Prof, Cohen, Geoff, MSc, Davis, Stephen, Prof, Donnan, Geoffrey, Prof, Grotta, James, Prof, Howard, George, Prof, Kaste, Markku, Prof, Koga, Masatoshi, MD, von Kummer, Ruediger, Prof, Lansberg, Maarten, MD, Lindley, Richard I, Prof, Murray, Gordon, Prof, Olivot, Jean Marc, Prof, Parsons, Mark, Prof, Tilley, Barbara, Prof, Toni, Danilo, MD, Toyoda, Kazunori, Prof, Wahlgren, Nils, Prof, Wardlaw, Joanna, Prof, Whiteley, William, MD, del Zoppo, Gregory J, Prof, Baigent, Colin, Prof, Sandercock, Peter, Prof, Hacke, Werner, Prof

“…Summary Background Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times since stroke onset, in…”
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The neurovascular unit in the setting of stroke by Del Zoppo, G. J.

“…del Zoppo GJ (University of Washington, Seattle, WA, USA). The neurovascular unit in the setting of stroke (Review). J Intern Med 2010; 267: 156–171. . …”
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Inflammation and the neurovascular unit in the setting of focal cerebral ischemia by del Zoppo, G.J

“…Abstract Responses to focal cerebral ischemia by neurons and adjacent microvessels are rapid, simultaneous, and topographically related. Recent observations…”
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Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis by Whiteley, William N, BM, Emberson, Jonathan, PhD, Lees, Kennedy R, Prof, Blackwell, Lisa, BSc, Albers, Gregory, Prof, Bluhmki, Erich, Prof, Brott, Thomas, Prof, Cohen, Geoff, MSc, Davis, Stephen, Prof, Donnan, Geoffrey, Prof, Grotta, James, MD, Howard, George, Prof, Kaste, Markku, Prof, Koga, Masatoshi, MD, von Kummer, Rüdiger, Prof, Lansberg, Maarten G, Prof, Lindley, Richard I, Prof, Lyden, Patrick, Prof, Olivot, Jean Marc, Prof, Parsons, Mark, Prof, Toni, Danilo, Prof, Toyoda, Kazunori, Prof, Wahlgren, Nils, Prof, Wardlaw, Joanna, Prof, del Zoppo, Gregory J, Prof, Sandercock, Peter, Prof, Hacke, Werner, Prof, Baigent, Colin, Prof

“…Summary Background Randomised trials have shown that alteplase improves the odds of a good outcome when delivered within 4·5 h of acute ischaemic stroke…”
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Cerebral Microvessel Responses to Focal Ischemia by del Zoppo, Gregory J, Mabuchi, Takuma

“…Cerebral microvessels have a unique ultrastructure form, which allows for the close relationship of the endothelium and blood elements to the neurons they…”
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Guidelines for the early management of patients with ischemic stroke: A scientific statement from the Stroke Council of the American Stroke Association by ADAMS, Harold P, ADAMS, Robert J, MARLER, John R, HADEMENOS, George J, BROTT, Thomas, DEL ZOPPO, Gregory J, FURLAN, Anthony, GOLDSTEIN, Larry B, GRUBB, Robert L, HIGASHIDA, Randall, KIDWELL, Chelsea, KWIATKOWSKI, Thomas G

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Focal cerebral ischemia induces active proteases that degrade microvascular matrix by FUKUDA, Shunichi, FINI, Catherine A, MABUCHI, Takuma, KOZIOL, James A, EGGLESTON, Leonard L, DEL ZOPPO, Gregory J

“…Focal cerebral ischemia causes microvessel matrix degradation and generates proteases known to degrade this matrix. However, proof that the proteases generated…”
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Increased expression of fibronectin and the alpha 5 beta 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia by Milner, Richard, Hung, Stephanie, Erokwu, Bernadette, Dore-Duffy, Paula, LaManna, Joseph C, del Zoppo, Gregory J

“…The extracellular matrix (ECM) is an important regulator of angiogenesis and vascular remodeling. We showed previously that angiogenic capillaries in the…”
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Role for Matrix Metalloproteinase 9 After Focal Cerebral Ischemia: Effects of Gene Knockout and Enzyme Inhibition With BB-94 by Asahi, Minoru, Asahi, Kazuko, Jung, Jae-Chang, del Zoppo, Gregory J., Fini, M. Elizabeth, Lo, Eng H.

“…It has been shown recently that matrix metalloproteinases (MMPs) are elevated after cerebral ischemia. In the current study, we investigated the…”
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Hemorrhagic transformation within 36 hours of a cerebral infarct : Relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) Cohort by FIORELLI, M, BASTIANELLO, S, VON KUMMER, R, DEL ZOPPO, G. J, LARRUE, V, LESAFFRE, E, RINGLEB, A. P, LORENZANO, S, MANELFE, C, BOZZAO, L

“…The clinical correlates of the varying degrees of early hemorrhagic transformation of a cerebral infarct are unclear. We investigated the cohort of a…”
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Recommendations for standards regarding preclinical neuroprotective and restorative drug development by Finklestein, Seth P, Fisher, Marc, Furlan, Anthony J, Goldstein, Larry B

“…The plethora of failed clinical trials with neuroprotective drugs for acute ischemic stroke have raised justifiable concerns about how best to proceed for the…”
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Bleeding in the brain: Amyloid-β may keep clots away by del Zoppo, Gregory J

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Matrix Metalloproteinases Increase Very Early During Experimental Focal Cerebral Ischemia by Heo, Ji Hoe, Lucero, Jacinta, Abumiya, Takeo, Koziol, James A., Copeland, Brian R., del Zoppo, Gregory J.

“…Microvascular integrity is lost during focal cerebral ischemia. The degradation of the basal lamina and extracellular matrix are, in part, responsible for the…”
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