Search Results - "del Rincón, Sonia V."

Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism by Dahabieh, Michael S., Di Pietro, Erminia, Jangal, Maïka, Goncalves, Christophe, Witcher, Michael, Braverman, Nancy E., del Rincón, Sonia V.

“…Cancer is irrevocably linked to aberrant metabolic processes. While once considered a vestigial organelle, we now know that peroxisomes play a central role in…”
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MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma by Zhan, Yao, Guo, Jun, Yang, William, Goncalves, Christophe, Rzymski, Tomasz, Dreas, Agnieszka, Żyłkiewicz, Eliza, Mikulski, Maciej, Brzózka, Krzysztof, Golas, Aniela, Kong, Yan, Ma, Meng, Huang, Fan, Huor, Bonnie, Guo, Qianyu, da Silva, Sabrina Daniela, Torres, Jose, Cai, Yutian, Topisirovic, Ivan, Su, Jie, Bijian, Krikor, Alaoui-Jamali, Moulay A, Huang, Sidong, Journe, Fabrice, Ghanem, Ghanem E, Miller, Jr, Wilson H, Del Rincón, Sonia V

“…Melanoma can be stratified into unique subtypes based on distinct pathologies. The acral/mucosal melanoma subtype is characterized by aberrant and constitutive…”
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Peroxisome disruption alters lipid metabolism and potentiates antitumor response with MAPK-targeted therapy in melanoma by Huang, Fan, Cai, Feiyang, Dahabieh, Michael S, Gunawardena, Kshemaka, Talebi, Ali, Dehairs, Jonas, El-Turk, Farah, Park, Jae Yeon, Li, Mengqi, Goncalves, Christophe, Gagnon, Natascha, Su, Jie, LaPierre, Judith H, Gaub, Perrine, Joyal, Jean-Sebastien, Mitchell, John J, Swinnen, Johannes V, Miller, Wilson H., Jr, del Rincon, Sonia V

“…Melanomas reprogram their metabolism to rapidly adapt to therapy-induced stress conditions, allowing them to persist and ultimately develop resistance. We…”
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Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy by Bartish, Margarita, Del Rincón, Sonia V, Rudd, Christopher E, Saragovi, H Uri

“…Though a healthy immune system is capable of recognizing and eliminating emergent cancerous cells, an established tumor is adept at escaping immune…”
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Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis by Dahabieh, Michael S, Ha, ZongYi, Di Pietro, Erminia, Nichol, Jessica N, Bolt, Alicia M, Goncalves, Christophe, Dupéré-Richer, Daphné, Pettersson, Filippa, Mann, Koren K, Braverman, Nancy E, del Rincón, Sonia V, Miller, Wilson H

“…Peroxisomes are a critical rheostat of reactive oxygen species (ROS), yet their role in drug sensitivity and resistance remains unexplored. Gene expression…”
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Development and validation of a method for profiling post-translational modification activities using protein microarrays by Del Rincón, Sonia V, Rogers, Jeff, Widschwendter, Martin, Sun, Dahui, Sieburg, Hans B, Spruck, Charles

“…Post-translational modifications (PTMs) impact on the stability, cellular location, and function of a protein thereby achieving a greater functional diversity…”
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The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment by Bartish, Margarita, Abraham, Madelyn J., Gonçalves, Christophe, Larsson, Ola, Rolny, Charlotte, del Rincón, Sonia V.

“…Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA translation. There is mounting evidence that dysregulation of mRNA…”
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Melanoma Plasticity: Promoter of Metastasis and Resistance to Therapy by Huang, Fan, Santinon, François, Flores González, Raúl Ernesto, Del Rincón, Sonia V

“…Melanoma is the deadliest form of skin cancer. Although targeted therapies and immunotherapies have revolutionized the treatment of metastatic melanoma, most…”
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Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism by DEL RINCON, Sonia V, QI GUO, MORELLI, Catia, SHIU, Hoi-Ying, SURMACZ, Eva, MILLER, Wilson H

“…Insulin receptor substrate-1 (IRS-1) mediates signaling from the insulin-like growth factor type-I receptor. We found that all-trans retinoic acid (RA)…”
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The MNK1/2-eIF4E Axis as a Potential Therapeutic Target in Melanoma by Prabhu, Sathyen A, Moussa, Omar, Miller, Jr, Wilson H, Del Rincón, Sonia V

“…Melanoma is a type of skin cancer that originates in the pigment-producing cells of the body known as melanocytes. Most genetic aberrations in melanoma result…”
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MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma by Zhan, Yao, Guo, Jun, Yang, William, Goncalves, Christophe, Rzymski, Tomasz, Dreas, Agnieszka, Żyłkiewicz, Eliza, Mikulski, Maciej, Brzózka, Krzysztof, Golas, Aniela, Kong, Yan, Ma, Meng, Huang, Fan, Huor, Bonnie, Guo, Qianyu, da Silva, Sabrina Daniela, Torres, Jose, Cai, Yutian, Topisirovic, Ivan, Su, Jie, Bijian, Krikor, Alaoui-Jamali, Moulay A, Huang, Sidong, Journe, Fabrice, Ghanem, Ghanem E, Miller, Jr, Wilson H, Del Rincón, Sonia V

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Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses by Huang, Fan, Gonçalves, Christophe, Bartish, Margarita, Rémy-Sarrazin, Joelle, Issa, Mark E, Cordeiro, Brendan, Guo, Qianyu, Emond, Audrey, Attias, Mikhael, Yang, William, Plourde, Dany, Su, Jie, Gimeno, Marina Godoy, Zhan, Yao, Galán, Alba, Rzymski, Tomasz, Mazan, Milena, Masiejczyk, Magdalena, Faber, Jacek, Khoury, Elie, Benoit, Alexandre, Gagnon, Natascha, Dankort, David, Journe, Fabrice, Ghanem, Ghanem E, Krawczyk, Connie M, Saragovi, H Uri, Piccirillo, Ciriaco A, Sonenberg, Nahum, Topisirovic, Ivan, Rudd, Christopher E, Miller, Jr, Wilson H, Del Rincón, Sonia V

“…Melanomas commonly undergo a phenotype switch, from a proliferative to an invasive state. Such tumor cell plasticity contributes to immunotherapy resistance;…”
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MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ by Guo, Qianyu, Li, Vivian Z, Nichol, Jessica N, Huang, Fan, Yang, William, Preston, Samuel E J, Talat, Zahra, Lefrère, Hanne, Yu, Henry, Zhang, Guihua, Basik, Mark, Gonçalves, Christophe, Zhan, Yao, Plourde, Dany, Su, Jie, Torres, Jose, Marques, Maud, Habyan, Sara Al, Bijian, Krikor, Amant, Frédéric, Witcher, Michael, Behbod, Fariba, McCaffrey, Luke, Alaoui-Jamali, Moulay, Giannakopoulos, Nadia V, Brackstone, Muriel, Postovit, Lynne-Marie, Del Rincón, Sonia V, Miller, Jr, Wilson H

“…The mechanisms by which breast cancers progress from relatively indolent ductal carcinoma (DCIS) to invasive ductal carcinoma (IDC) are not well understood…”
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Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition by Shorstova, Tatiana, Su, Jie, Zhao, Tiejun, Dahabieh, Michael, Leibovitch, Matthew, De Sa Tavares Russo, Mariana, Avizonis, Daina, Rajkumar, Shivshankari, Watson, Ian R, Del Rincón, Sonia V, Miller, Jr, Wilson H, Foulkes, William D, Witcher, Michael

“…Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare but often lethal cancer that is diagnosed at a median age of 24 years. Optimal…”
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Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance by Dahabieh, Michael S., Huang, Fan, Goncalves, Christophe, Flores González, Raúl Ernesto, Prabhu, Sathyen, Bolt, Alicia, Di Pietro, Erminia, Khoury, Elie, Heath, John, Xu, Zi Yi, Rémy-Sarrazin, Joelle, Mann, Koren K., Orthwein, Alexandre, Boisvert, François-Michel, Braverman, Nancy, Miller, Wilson H., del Rincón, Sonia V.

“…Promoting the macroautophagy/autophagy-mediated degradation of specific proteins and organelles can potentially be utilized to induce apoptosis in cancer cells…”
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Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses by Huang, Fan, Gonçalves, Christophe, Bartish, Margarita, Rémy-Sarrazin, Joelle, Issa, Mark E, Cordeiro, Brendan, Guo, Qianyu, Emond, Audrey, Attias, Mikhael, Yang, William, Plourde, Dany, Su, Jie, Gimeno, Marina Godoy, Zhan, Yao, Galán, Alba, Rzymski, Tomasz, Mazan, Milena, Masiejczyk, Magdalena, Faber, Jacek, Khoury, Elie, Benoit, Alexandre, Gagnon, Natascha, Dankort, David, Journe, Fabrice, Ghanem, Ghanem E, Krawczyk, Connie M, Saragovi, H Uri, Piccirillo, Ciriaco A, Sonenberg, Nahum, Topisirovic, Ivan, Rudd, Christopher E, Miller, Jr, Wilson H, Del Rincón, Sonia V

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A comparative study of CARE 2D and N2V 2D for tissue‐specific denoising in second harmonic generation imaging by Aghigh, Arash, Jargot, Gaëtan, Zaouter, Charlotte, Preston, Samuel E. J., Mohammadi, Melika Saadat, Ibrahim, Heide, Del Rincón, Sonia V., Patten, Kessen, Légaré, François

“…This study explored the application of deep learning in second harmonic generation (SHG) microscopy, a rapidly growing area. This study focuses on the impact…”
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Translation of cancer immunotherapy from the bench to the bedside by Guo, Qianyu, Huang, Fan, Goncalves, Christophe, Del Rincón, Sonia V, Miller, Jr, Wilson H

“…The tremendous success of immune checkpoint blockades has revolutionized cancer management. Our increased understanding of the cell types that compose the…”
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Retinoic acid-induced growth arrest of MCF-7 cells involves the selective regulation of the IRS-1 PI 3-kinase AKT pathway by DEL RINCON, Sonia V, ROUSSEAU, Caroline, SAMANTA, Ratna, MILLER, Wilson H

“…In the MCF-7 breast cancer cell line, insulin-like growth factors (IGFs) are known to elicit antiproliferative actions via the insulin receptor substrate-1…”
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Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis by Petruccelli, Luca A, Pettersson, Filippa, Del Rincón, Sonia V, Guilbert, Cynthia, Licht, Jonathan D, Miller, Jr, Wilson H

“…Histone deacetylase inhibitors (HDI) show activity in a broad range of hematologic and solid malignancies, yet the percentage of patients in any given…”
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