Search Results - "del Mercato, Loretta L"
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A synergic approach to enhance long-term culture and manipulation of MiaPaCa-2 pancreatic cancer spheroids
Published in Scientific reports (23-06-2020)“…Tumour spheroids have the potential to be used as preclinical chemo-sensitivity assays. However, the production of three-dimensional (3D) tumour spheroids…”
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pH-sensing hybrid hydrogels for non-invasive metabolism monitoring in tumor spheroids
Published in Materials today bio (01-06-2023)“…The constant increase in cancer incidence and mortality pushes biomedical research towards the development of in vitro 3D systems able to faithfully reproduce…”
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Probing the pH Microenvironment of Mesenchymal Stromal Cell Cultures on Additive‐Manufactured Scaffolds
Published in Small (Weinheim an der Bergstrasse, Germany) (01-08-2020)“…Despite numerous advances in the field of tissue engineering and regenerative medicine, monitoring the formation of tissue regeneration and its metabolic…”
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Nanopharmacy: Inorganic nanoscale devices as vectors and active compounds
Published in Pharmacological research (01-08-2010)“…In this review we would like to aim at pharmaceuticals engineered on the nanoscale, i.e. pharmaceuticals where the nanomaterial plays the pivotal therapeutic…”
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Emerging Technologies for Cancer Research: Towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models
Published in Current medicinal chemistry (01-01-2018)“…In the present review, we describe three hot topics in cancer research such as circulating tumor cells, exosomes, and 3D environment models. The first section…”
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Preparation and Investigation of Thermally Annealed Zein–Propolis Electrospun Nanofibers for Biomedical Applications
Published in Macromolecular bioscience (01-05-2023)“…Zein, a corn‐derived protein, has a variety of applications ranging from drug delivery to tissue engineering and wound healing. This work aims to develop a…”
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Catalytic Self-Propulsion of Supramolecular Capsules Powered by Polyoxometalate Cargos
Published in Chemistry : a European journal (25-08-2014)“…Multicompartment, spherical microcontainers were engineered through a layer‐by‐layer polyelectrolyte deposition around a fluorescent core while integrating a…”
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8
Highly Sensitive Membrane-Based Pressure Sensors (MePS) for Real-Time Monitoring of Catalytic Reactions
Published in Analytical chemistry (Washington) (19-06-2018)“…Functional, flexible, and integrated lab-on-chips, based on elastic membranes, are capable of fine response to external stimuli, so to pave the way for many…”
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9
Magnetic Capsules for NMR Imaging: Effect of Magnetic Nanoparticles Spatial Distribution and Aggregation
Published in Journal of physical chemistry. C (14-04-2011)“…Magnetic and NMR relaxivity properties of γ-Fe2O3 nanoparticles embedded into the walls of polyelectrolyte multilayer capsules and freely dispersed in a sodium…”
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10
Towards the development of human immune-system-on-a-chip platforms
Published in Drug discovery today (01-02-2019)“…•Immune system plays a critical role in maintaining homeostasis of the human body.•Development of immune-system-on-a-chip platforms is in its infancy.•Several…”
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11
A pH-sensor scaffold for mapping spatiotemporal gradients in three-dimensional in vitro tumour models
Published in Biosensors & bioelectronics (15-09-2022)“…The detection of extracellular pH at single cell resolution is challenging and requires advanced sensibility. Sensing pH at high spatial and temporal…”
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Facile One Pot Synthesis of Hybrid Core–Shell Silica-Based Sensors for Live Imaging of Dissolved Oxygen and Hypoxia Mapping in 3D Cell Models
Published in ACS applied materials & interfaces (28-08-2024)“…Fluorescence imaging allows for noninvasively visualizing and measuring key physiological parameters like pH and dissolved oxygen. In our work, we created two…”
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Highly Sensitive Fluorescent pH Microsensors Based on the Ratiometric Dye Pyranine Immobilized on Silica Microparticles
Published in Chemistry : a European journal (20-09-2021)“…Pyranine (HPTS) is a remarkably interesting pH‐sensitive dye that has been used for plenty of applications. Its high quantum yield and extremely sensitive…”
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14
Electrospun nanofibers in cancer research: from engineering of in vitro 3D cancer models to therapy
Published in Biomaterials science (21-09-2020)“…Electrospinning is historically related to tissue engineering due to its ability to produce nano-/microscale fibrous materials with mechanical and functional…”
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Fully Automated Computational Approach for Precisely Measuring Organelle Acidification with Optical pH Sensors
Published in ACS applied materials & interfaces (27-04-2022)“…pH balance and regulation within organelles are fundamental to cell homeostasis and proliferation. The ability to track pH in cells becomes significantly…”
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Ratiometric Organic Fibers for Localized and Reversible Ion Sensing with Micrometer-Scale Spatial Resolution
Published in Small (Weinheim an der Bergstrasse, Germany) (22-12-2015)“…A fundamental issue in biomedical and environmental sciences is the development of sensitive and robust sensors able to probe the analyte of interest, under…”
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Co-loading of doxorubicin and iron oxide nanocubes in polycaprolactone fibers for combining Magneto-Thermal and chemotherapeutic effects on cancer cells
Published in Journal of colloid and interface science (01-02-2022)“…[Display omitted] Among the strategies to fight cancer, multi-therapeutic approaches are considered as a wise choice to put in place multiple weapons to…”
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Probing Single-Cell Fermentation Fluxes and Exchange Networks via pH-Sensing Hybrid Nanofibers
Published in ACS nano (28-02-2023)“…The homeostatic control of their environment is an essential task of living cells. It has been hypothesized that, when microenvironmental pH inhomogeneities…”
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Biocompatible multilayer capsules engineered with a graphene oxide derivative: synthesis, characterization and cellular uptake
Published in Nanoscale (14-04-2016)“…Graphene-based capsules have strong potential for a number of applications, including drug/gene delivery, tissue engineering, sensors, catalysis and reactors…”
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Quantifying heterogeneity to drug response in cancer-stroma kinetics
Published in Proceedings of the National Academy of Sciences - PNAS (14-03-2023)“…A crucial challenge in medicine is choosing which drug (or combination) will be the most advantageous for a particular patient. Usually, drug response rates…”
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