Search Results - "del Mar Maldonado, Maria"

Targeting Rac and Cdc42 GTPases in Cancer by Maldonado, María Del Mar, Dharmawardhane, Suranganie

“…Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and are implicated in epithelial to mesenchymal transition, cell-cycle…”
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Targeting Rac and Cdc42 GEFs in Metastatic Cancer by Maldonado, Maria Del Mar, Medina, Julia Isabel, Velazquez, Luis, Dharmawardhane, Suranganie

“…The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin…”
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Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography–Tandem Mass Spectrometry by Maldonado, María del Mar, Rosado-González, Gabriela, Bloom, Joseph, Duconge, Jorge, Ruiz-Calderón, Jean F, Hernández-O’Farrill, Eliud, Vlaar, Cornelis, Rodríguez-Orengo, José F, Dharmawardhane, Suranganie

“…The Rho GTPases Rac and Cdc42 are potential targets against metastatic diseases. We characterized the small molecule MBQ-167 as an effective dual Rac/Cdc42…”
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Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer by Cruz-Collazo, Ailed, Ruiz-Calderon, Jean F, Picon, Hector, Borrero-Garcia, Luis D, Lopez, Irmaris, Castillo-Pichardo, Linette, Del Mar Maldonado, Maria, Duconge, Jorge, Medina, Julia I, Bayro, Marvin J, Hernández-O'Farrill, Eliud, Vlaar, Cornelis P, Dharmawardhane, Suranganie

“…Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer, with a high predisposition for locally invasive and metastatic cancer. With the…”
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Rac inhibition as a novel therapeutic strategy for EGFR/HER2 targeted therapy resistant breast cancer by Borrero-García, Luis D, Del Mar Maldonado, Maria, Medina-Velázquez, Julia, Troche-Torres, Angel L, Velazquez, Luis, Grafals-Ruiz, Nilmary, Dharmawardhane, Suranganie

“…Even though targeted therapies are available for cancers expressing oncogenic epidermal growth receptor (EGFR) and (or) human EGFR2 (HER2), acquired or…”
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A Standardized Extract of Lentinula edodes Cultured Mycelium Inhibits Pseudomonas aeruginosa Infectivity Mechanisms by Tena-Garitaonaindia, Mireia, Ceacero-Heras, Diego, Montoro, María Del Mar Maldonado, de Medina, Fermín Sánchez, Martínez-Augustin, Olga, Daddaoua, Abdelali

“…The priority pathogen list of the World Health Organization classified as the second top critical pathogen. Hence, the development of novel antibacterial…”
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Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42 by Medina, Julia I, Cruz-Collazo, Ailed, Del Mar Maldonado, Maria, Gascot, Tatiana Matos, Borrero-Garcia, Luis D, Cooke, Mariana, Kazanietz, Marcelo G, O'Farril, Eliud Hernandez, Vlaar, Cornelis P, Dharmawardhane, Suranganie

“…Rac and Cdc42, are homologous GTPases that regulate cell migration, invasion, and cell cycle progression; thus, representing key targets for metastasis…”
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Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice by Reig-López, Javier, Maldonado, María Del Mar, Merino-Sanjuan, Matilde, Cruz-Collazo, Ailed M, Ruiz-Calderón, Jean F, Mangas-Sanjuán, Victor, Dharmawardhane, Suranganie, Duconge, Jorge

“…MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug…”
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Single Nucleotide Polymorphisms in the Vitamin D Metabolic Pathway as Survival Biomarkers in Colorectal Cancer by Pérez-Durán, Carmen, Márquez-Pete, Noelia, Gálvez-Navas, José María, Cura, Yasmin, Rojo-Tolosa, Susana, Pineda-Lancheros, Laura Elena, Ramírez-Tortosa, MCarmen, García-Collado, Carlos, Maldonado-Montoro, María del Mar, Villar-del-Moral, Jesús María, Pérez-Ramírez, Cristina, Jiménez-Morales, Alberto

“…Several studies have suggested that single nucleotide polymorphisms (SNPs) related to vitamin D metabolism may affect CRC carcinogenesis and survival. The aim…”
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Influence of the FCGR2A rs1801274 and FCGR3A rs396991 Polymorphisms on Response to Abatacept in Patients with Rheumatoid Arthritis by Márquez Pete, Noelia, Maldonado Montoro, María del Mar, Pérez Ramírez, Cristina, Martínez Martínez, Fernando, Martínez de la Plata, Juan Enrique, Daddaoua, Abdelali, Jiménez Morales, Alberto

“…Abatacept (ABA) is an immunosuppressant indicated for treatment of rheumatoid arthritis (RA). Effectiveness might be influenced by clinical RA variants and…”
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Impact of Single-Nucleotide Polymorphisms of CTLA-4 , CD80 and CD86 on the Effectiveness of Abatacept in Patients with Rheumatoid Arthritis by Marquez Pete, Noelia, Maldonado Montoro, María Del Mar, Pérez Ramírez, Cristina, Sánchez Martín, Almudena, Martínez de la Plata, Juan Enrique, Martínez Martínez, Fernando, Caliz Caliz, Rafael, Daddaoua, Abdelali, Ramírez Tortosa, María Del Carmen, Jiménez Morales, Alberto

“…Abatacept (ABA) is used as a first-line treatment in patients diagnosed with moderate and severe rheumatoid arthritis (RA). The interindividual response to ABA…”
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Corrigendum: A standardized extract of Lentinula edodes cultured mycelium inhibits Pseudomonas aeruginosa infectivity mechanisms by Tena-Garitaonaindia, Mireia, Ceacero-Heras, Diego, Montoro, María Del Mar Maldonado, de Medina, Fermín Sánchez, Martínez-Augustin, Olga, Daddaoua, Abdelali

“…[This corrects the article DOI: 10.3389/fmicb.2022.814448.]…”
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Blockade of tumor-derived colony-stimulating factor 1 (CSF1) promotes an immune-permissive tumor microenvironment by Maldonado, Maria del Mar, Schlom, Jeffrey, Hamilton, Duane H.

“…The macrophage colony-stimulating factor 1 (CSF1) is a chemokine essential for the survival, proliferation, and differentiation of mononuclear phagocytes from…”
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Abstract 623: Investigating potential off-target effects of the dual Rac and Cdc42 inhibitor MBQ-167 by Picon, Hector M., Maldonado, Maria Del Mar, Flanagan, Surangani F. Dharmawardhane

“…Metastasis is a major cause of death in epithelial cancers, largely because of a lack of effective treatments. The metastatic inhibitor MBQ-167 was developed…”
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Impact of a risk-sharing agreement in rheumatoid arthritis in Spain by García-Collado, Carlos Gustavo, Martínez-de-la-Plata, Juan Enrique, Montoro, María del Mar Maldonado, Morales, Alberto Jiménez, Hernández, Miguel Ángel Calleja, Martínez, Fernando Martínez

“…•The effectiveness of new drugs may differ from efficacy in clinical trials.•Adequately designed RSAs are useful instruments for the sustainability of…”
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Abstract 5085: Blockade of tumor derived CSF1 promotes an immune-permissive tumor microenvironment by Maldonado, Maria Del Mar, Hamilton, Duane H., Schlom, Jeffrey

“…The macrophage colony stimulating factor 1 (CSF1) is a chemokine essential for the survival, proliferation, and differentiation of especially mononuclear…”
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Sensitization of Anti‐EGFR/HER2 Targeted Therapy Resistance in Breast Cancer Cells by MiRNA Manipulation by Vigo‐Morales, Paula Rocío, Borrero‐Garcia, Luis Daniel, Del Mar Maldonado, Maria, Dharmawardhane, Suranganie

“…The aim of this study is to explore the resistance mechanisms to anti‐epidermal growth factor receptor (EGFR) and anti‐human epidermal growth factor receptor…”
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Abstract 3020: Tumor pharmacokinetics of the metastatic cancer inhibitor MBQ-167 in mice by Del Mar Maldonado, Maria, Cruz-Collazo, Ailed M., Borrero-García, Luis D., Rosado-González, Gabriela T., Ruiz-Calderon, Jean F., Duconge, Jorge, Dharmawardhane, Suranganie

“…The Rho GTPases Rac and Cdc42 are potential targets against metastatic disease. Our group characterized the small molecule MBQ-167 as an effective dual…”
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Association between polymorphisms in the vitamin D receptor and susceptibility to multiple sclerosis by Cancela Díez, Bárbara, Pérez-Ramírez, Cristina, Maldonado-Montoro, María del Mar, Carrasco-Campos, María Isabel, Sánchez Martín, Almudena, Pineda Lancheros, Laura Elena, Martínez-Martínez, Fernando, Calleja-Hernández, Miguel Ángel, Ramírez-Tortosa, María Carmen, Jiménez-Morales, Alberto

“…Multiple sclerosis (MS) is a neurodegenerative chronic inflammatory. Mutations in the vitamin D receptor (VDR) gene can substantially affect serum vitamin D…”
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Overcoming Resistance to Anti‐EGFR Therapy in Breast Cancer with Rac Inhibitors by Borrero‐Garcia, Luis Daniel, Troche‐Torres, Angel Luis, Maldonado, Maria del Mar, Dharmawardhane, Suranganie

“…Abstract only Epidermal growth factor receptor (EGFR) and human EGFR2 (HER2) targeted therapies have been successfully used in breast cancers that overexpress…”
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