Nodular diabetic glomerulosclerosis without diabetes mellitus

A 66-year-old white man presented with severe chronic renal failure. He had no past or present symptomatic glucose intolerance nor a family history of diabetes mellitus. Several fasting plasma glucose determinations, hemoglobin Alc and an oral glucose tolerance test were normal. Funduscopic ophthalm...

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Bibliographic Details
Published in:	Nephron (2015) Vol. 62; no. 3; p. 289
Main Authors:	da Silva, E C, Saldanha, L B, Pestalozzi, M S, del Bueno, I J, Barros, R T, Marcondes, M, Nussenzveig, I
Format:	Journal Article
Language:	English
Published:	Switzerland 1992
Subjects:	Aged Diabetic Nephropathies - etiology Diabetic Nephropathies - pathology Glucose Tolerance Test Humans Hypertension - complications Kidney Failure, Chronic - etiology Kidney Failure, Chronic - pathology Male
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Summary:	A 66-year-old white man presented with severe chronic renal failure. He had no past or present symptomatic glucose intolerance nor a family history of diabetes mellitus. Several fasting plasma glucose determinations, hemoglobin Alc and an oral glucose tolerance test were normal. Funduscopic ophthalmoscopy and retinal fluorescein angiography did not demonstrate diabetic retinopathy. The kidney biopsy showed nodular diabetic nephropathy, with increased mesangial matrix, thickened glomerular basement membrane, and afferent and efferent glomerular arteriolar hyalinization. The diagnosis of nodular diabetic nephropathy was made in this patient in the absence of past or present or familial evidence of diabetes mellitus.
ISSN:	1660-8151
DOI:	10.1159/000187061