Clinical characteristics and management responses in 85 HIV-infected patients with oral candidiasis

Eighty-five consecutively seen HIV-positive persons with oral candidiasis were evaluated for clinical characteristics, staging of HIV disease, quantitation of candidal colony formation, and response to systemic antifungal treatment with Nizoral (ketoconazole). Fifty-five had CD4 counts less than 200...

Full description

Saved in:

Bibliographic Details
Published in:	Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 82; no. 4; pp. 402 - 407
Main Authors:	Silverman, Sol, Gallo, John W., McKnight, Margaret L., Mayer, Priscilla, deSanz, Sarah, Tan, Margaret M.
Format:	Journal Article
Language:	English
Published:	St. Louis, MO Mosby, Inc 01-10-1996 Elsevier
Subjects:	AIDS-Related Opportunistic Infections - drug therapy AIDS-Related Opportunistic Infections - immunology AIDS-Related Opportunistic Infections - microbiology AIDS/HIV Antifungal Agents - administration & dosage Antifungal Agents - therapeutic use Biological and medical sciences Candidiasis, Oral - drug therapy Candidiasis, Oral - etiology Candidiasis, Oral - immunology Candidiasis, Oral - microbiology CD4 Lymphocyte Count Colony Count, Microbial Dentistry Dose-Response Relationship, Drug Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Ketoconazole - administration & dosage Ketoconazole - therapeutic use Medical sciences Smoking Human Immunopathology Imidazole derivatives Candidiasis Mycosis Treatment efficiency AIDS Immune deficiency Infection Oral cavity Symptomatology Antifungal agent Chemotherapy Association Treatment Viral disease ENT disease Oral cavity disease
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Eighty-five consecutively seen HIV-positive persons with oral candidiasis were evaluated for clinical characteristics, staging of HIV disease, quantitation of candidal colony formation, and response to systemic antifungal treatment with Nizoral (ketoconazole). Fifty-five had CD4 counts less than 200. There was an inconsistent association between clinical signs, patient symptoms, CD4 counts, and candidal colony-forming units. However, there was a trend toward higher colony-forming unit counts (>500) in patients with lower CD4 cells (<200). Sixty-five patients had a complete clinical response to the ketoconazole treatment (200 mg daily for 7 days), even though 81% of posttreatment cultures remained positive. Nonsmokers were more likely to respond to antifungal treatment when compared with smokers, and there was a slight tendency for complete responses when colony-forming unit counts were low. The most common lesion presentation was a combination of the white (pseudomembranous) and red (erythematous) forms. Forty-nine percent had complaints of pain. The variable responses indicated the importance of flexible dose-time and drug considerations in antifungal management. Candida albicans was the predominant species.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1079-2104 1528-395X
DOI:	10.1016/S1079-2104(96)80304-0