Search Results - "deCarli, Charles"

Impact of multiple pathologies on the threshold for clinically overt dementia by Kapasi, Alifiya, DeCarli, Charles, Schneider, Julie A.

“…Longitudinal clinical–pathological studies have increasingly recognized the importance of mixed pathologies (the coexistence of one or more neurodegenerative…”
Get full text

Imaging Markers of Vascular Brain Health: Quantification, Clinical Implications, and Future Directions by Vemuri, Prashanthi, Decarli, Charles, Duering, Marco

“…Cerebrovascular disease (CVD) manifests through a broad spectrum of mechanisms that negatively impact brain and cognitive health. Oftentimes, CVD changes…”
Get full text

Update on diverse vascular cognitive impairment (VCID) by DeCarli, Charles

“…Background. As the US population becomes increasingly older and more diverse, the number of Americans with dementia is expected to rise substantially,…”
Get full text

Education amplifies brain atrophy effect on cognitive decline: implications for cognitive reserve by Mungas, Dan, Gavett, Brandon, Fletcher, Evan, Farias, Sarah Tomaszewski, DeCarli, Charles, Reed, Bruce

“…Level of education is often regarded as a proxy for cognitive reserve in older adults. This implies that brain degeneration has a smaller effect on cognitive…”
Get full text

Interpretable classification of Alzheimer’s disease pathologies with a convolutional neural network pipeline by Tang, Ziqi, Chuang, Kangway V., DeCarli, Charles, Jin, Lee-Way, Beckett, Laurel, Keiser, Michael J., Dugger, Brittany N.

“…Neuropathologists assess vast brain areas to identify diverse and subtly-differentiated morphologies. Standard semi-quantitative scoring approaches, however,…”
Get full text

Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study by Maillard, Pauline, PhD, Seshadri, Sudha, MD, Beiser, Alexa, PhD, Himali, Jayandra J, MS, Au, Rhoda, PhD, Fletcher, Evan, PhD, Carmichael, Owen, PhD, Wolf, Philip A, MD, DeCarli, Charles, Dr

“…Summary Background Previous studies have identified effects of age and vascular risk factors on brain injury in elderly individuals. We aimed to establish…”
Get full text

Association of Loneliness With 10-Year Dementia Risk and Early Markers of Vulnerability for Neurocognitive Decline by Salinas, Joel, Beiser, Alexa S., Samra, Jasmeet K., O'Donnell, Adrienne, DeCarli, Charles S., Gonzales, Mitzi M., Aparicio, Hugo J., Seshadri, Sudha

“…Loneliness is common, and its prevalence is rising. The relationship of loneliness with subsequent dementia and the early preclinical course of Alzheimer…”
Get full text

Blood pressure from mid‐ to late life and risk of incident dementia by McGrath, Emer R, Beiser, Alexa S, DeCarli, Charles, Plourde, Kendra L, Vasan, Ramachandran S, Greenberg, Steven M, Seshadri, Sudha

“…OBJECTIVE:To determine the association between blood pressure during midlife (40–64 years) to late life (≥65 years) and risk of incident dementia. METHODS:This…”
Get full text

Amylin deposition in the brain: A second amyloid in Alzheimer disease? by Jackson, Kaleena, Barisone, Gustavo A., Diaz, Elva, Jin, Lee-way, DeCarli, Charles, Despa, Florin

“…Objective Hyperamylinemia, a common pancreatic disorder in obese and insulin‐resistant patients, is known to cause amylin oligomerization and cytotoxicity in…”
Get full text

Global & Community Health: Brief in-hospital cognitive screening anticipates complex admissions and may detect dementia by Bissig, David, DeCarli, Charles S.

“…OBJECTIVEWith the long-term goal of improving community health by screening for dementia, we tested the utility of integrating the Six-Item Screener (SIS) into…”
Get full text

Biological heterogeneity in ADNI amnestic mild cognitive impairment by Nettiksimmons, Jasmine, DeCarli, Charles, Landau, Susan, Beckett, Laurel

“…Abstract Background Previous work examining normal controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI) identified substantial biological…”
Get full text

Associations between serum cholesterol levels and cerebral amyloidosis by Reed, Bruce, Villeneuve, Sylvia, Mack, Wendy, DeCarli, Charles, Chui, Helena C, Jagust, William

“…Because deposition of cerebral β-amyloid (Aβ) seems to be a key initiating event in Alzheimer disease (AD), factors associated with increased deposition are of…”
Get more information

Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study by Tan, Zaldy S, Spartano, Nicole L, Beiser, Alexa S, DeCarli, Charles, Auerbach, Sanford H, Vasan, Ramachandran S, Seshadri, Sudha

“…Several longitudinal studies found an inverse relationship between levels of physical activity and cognitive decline, dementia, and/or Alzheimer's disease…”
Get full text

MRI-Visible Perivascular Spaces and Risk of Incident Dementia: The Framingham Heart Study by Romero, Jose Rafael, Pinheiro, Adlin, Aparicio, Hugo J., DeCarli, Charles S., Demissie, Serkalem, Seshadri, Sudha

“…Perivascular spaces (PVS) visible on MRI scans may represent key aspects in the pathophysiology of stroke and dementia, including cerebral small vessel disease…”
Get full text

Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's disease by Elahi, Fanny M., Casaletto, Kaitlin B., La Joie, Renaud, Walters, Samantha M., Harvey, Danielle, Wolf, Amy, Edwards, Lauren, Rivera-Contreras, Wilfredo, Karydas, Anna, Cobigo, Yann, Rosen, Howard J., DeCarli, Charles, Miller, Bruce L., Rabinovici, Gil D., Kramer, Joel H.

“…We investigated plasma proteomic markers of astrocytopathy, brain degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset…”
Get full text

Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia by Westwood, Andrew J, Beiser, Alexa, Jain, Nikita, Himali, Jayandra J, DeCarli, Charles, Auerbach, Sanford H, Pase, Matthew P, Seshadri, Sudha

“…OBJECTIVE:To evaluate the association between sleep duration and the risk of incident dementia and brain aging. METHODS:Self-reported total hours of sleep were…”
Get full text

Cerebral Microbleeds and risk of Incident Dementia: The Framingham Heart Study by Romero, José R., M.D, Beiser, Alexa, Ph.D, Himali, Jayandra J., Ph.D, Shoamanesh, Ashkan, M.D, DeCarli, Charles, M.D, Seshadri, Sudha, M.D

“…Abstract Cerebral microbleeds (CMB) are MRI markers attributed to the most common cerebral angiopathies in the elderly and in patients with dementia:…”
Get full text

Risk Factors, Stroke Prevention Treatments, and Prevalence of Cerebral Microbleeds in the Framingham Heart Study by Romero, José Rafael, Preis, Sarah R, Beiser, Alexa, DeCarli, Charles, Viswanathan, Anand, Martinez-Ramirez, Sergi, Kase, Carlos S, Wolf, Philip A, Seshadri, Sudha

“…BACKGROUND AND PURPOSE—Cerebral microbleeds (CMBs) are associated with increased risk of stroke and poor cognition. Vascular risk factors and medications used…”
Get full text

Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study by Echouffo-Tcheugui, Justin B, Conner, Sarah C, Himali, Jayandra J, Maillard, Pauline, DeCarli, Charles S, Beiser, Alexa S, Vasan, Ramachandran S, Seshadri, Sudha

“…OBJECTIVETo assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and…”
Get full text

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration by Wardlaw, Joanna M, Prof, Smith, Eric E, MD, Biessels, Geert J, MD, Cordonnier, Charlotte, Prof, Fazekas, Franz, Prof, Frayne, Richard, Prof, Lindley, Richard I, Prof, O'Brien, John T, Prof, Barkhof, Frederik, Prof, Benavente, Oscar R, Prof, Black, Sandra E, MD, Brayne, Carol, Prof, Breteler, Monique, Prof, Chabriat, Hugues, Prof, DeCarli, Charles, Prof, de Leeuw, Frank-Erik, MD, Doubal, Fergus, PhD, Duering, Marco, MD, Fox, Nick C, Prof, Greenberg, Steven, Prof, Hachinski, Vladimir, Prof, Kilimann, Ingo, MD, Mok, Vincent, Prof, Oostenbrugge, Robert van, Prof, Pantoni, Leonardo, MD, Speck, Oliver, Prof, Stephan, Blossom C M, PhD, Teipel, Stefan, Prof, Viswanathan, Anand, MD, Werring, David, PhD, Chen, Christopher, MD, Smith, Colin, MD, van Buchem, Mark, Prof, Norrving, Bo, Prof, Gorelick, Philip B, MD, Dichgans, Martin, Prof

“…Summary Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts,…”
Get full text