Search Results - "de la Rosa, Enrique J."

The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina by Sirés, Anna, Pazo-González, Mateo, López-Soriano, Joaquín, Méndez, Ana, de la Rosa, Enrique J, de la Villa, Pedro, Comella, Joan X, Hernández-Sánchez, Catalina, Solé, Montse

“…The short and long isoforms of FAIM (FAIM-S and FAIM-L) hold important functions in the central nervous system, and their expression levels are specifically…”
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Exploring the Origin and Physiological Significance of DNA Double Strand Breaks in the Developing Neuroretina by Álvarez-Lindo, Noemí, Suárez, Teresa, de la Rosa, Enrique J.

“…Genetic mosaicism is an intriguing physiological feature of the mammalian brain that generates altered genetic information and provides cellular, and…”
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Tlr2 Gene Deletion Delays Retinal Degeneration in Two Genetically Distinct Mouse Models of Retinitis Pigmentosa by Sánchez-Cruz, Alonso, Méndez, Andrea C, Lizasoain, Ignacio, de la Villa, Pedro, de la Rosa, Enrique J, Hernández-Sánchez, Catalina

“…Although considered a rare retinal dystrophy, retinitis pigmentosa (RP) is the primary cause of hereditary blindness. Given its diverse genetic etiology (>3000…”
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Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa by Sánchez-Cruz, Alonso, Hernández-Pinto, Alberto, Lillo, Concepción, Isiegas, Carolina, Marchena, Miguel, Lizasoain, Ignacio, Bosch, Fátima, de la Villa, Pedro, Hernández-Sánchez, Catalina, de la Rosa, Enrique J.

“…Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the…”
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Small molecules targeting glycogen synthase kinase 3 as potential drug candidates for the treatment of retinitis pigmentosa by Marchena, Miguel, Villarejo-Zori, Beatriz, Zaldivar-Diez, Josefa, Palomo, Valle, Gil, Carmen, Hernández-Sánchez, Catalina, Martínez, Ana, de la Rosa, Enrique J.

“…Retinitis pigmentosa (RP) is an inherited retinal dystrophy that courses with progressive degeneration of retinal tissue and loss of vision. Currently, RP is…”
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Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa by Sánchez-Cruz, Alonso, Hernández-Fuentes, María D, Murillo-Gómez, Cayetana, de la Rosa, Enrique J, Hernández-Sánchez, Catalina

“…Insulin-degrading enzyme (IDE) was named after its role as a proteolytic enzyme of insulin. However, recent findings suggest that IDE is a widely expressed,…”
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Balance between autophagic pathways preserves retinal homeostasis by Rodríguez‐Muela, Natalia, Koga, Hiroshi, García‐Ledo, Lucía, Villa, Pedro, Rosa, Enrique J., Cuervo, Ana María, Boya, Patricia

“…Summary Aging contributes to the appearance of several retinopathies and is the largest risk factor for aged‐related macular degeneration, major cause of…”
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Early Neural Cell Death Is an Extensive, Dynamic Process in the Embryonic Chick and Mouse Retina by Chavarría, Teresa, de la Rosa, Enrique J., de Pablo, Flora, Mayordomo, Raquel, Baleriola, Jimena

“…Orchestrated proliferation, differentiation, and cell death contribute to the generation of the complex cytoarchitecture of the central nervous system,…”
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Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells by Vázquez, Patricia, Arroba, Ana I., Cecconi, Francesco, de la Rosa, Enrique J., Boya, Patricia, De Pablo, Flora

“…Neuroepithelial cells undergoing differentiation efficiently remodel their cytoskeleton and shape in an energy-consuming process. The capacity of autophagy to…”
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RAG-2 deficiency results in fewer phosphorylated histone H2AX foci, but increased retinal ganglion cell death and altered axonal growth by Álvarez-Lindo, Noemí, Baleriola, Jimena, de los Ríos, Vivian, Suárez, Teresa, de la Rosa, Enrique J.

“…DNA double-strand breaks (DSBs), selectively visualized as γ-H2AX + foci, occur during the development of the central nervous system, including the retina,…”
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Silicon chips detect intracellular pressure changes in living cells by Gómez-Martínez, Rodrigo, Hernández-Pinto, Alberto M., Duch, Marta, Vázquez, Patricia, Zinoviev, Kirill, de la Rosa, Enrique J., Esteve, Jaume, Suárez, Teresa, Plaza, José A.

“…The ability to measure pressure changes inside different components of a living cell is important, because it offers an alternative way to study fundamental…”
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Dynamics of Central Remyelination and Treatment Evolution in a Model of Multiple Sclerosis with Optic Coherence Tomography by Benítez-Fernández, Rocío, Melero-Jerez, Carolina, Gil, Carmen, de la Rosa, Enrique J, Martínez, Ana, de Castro, Fernando

“…The need for remyelinating drugs is essential for healing disabling diseases such as multiple sclerosis (MS). One of the reasons for the lack of this class of…”
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Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa by Sánchez-Cruz, Alonso, Villarejo-Zori, Beatriz, Marchena, Miguel, Zaldivar-Díez, Josefa, Palomo, Valle, Gil, Carmen, Lizasoain, Ignacio, de la Villa, Pedro, Martínez, Ana, de la Rosa, Enrique J, Hernández-Sánchez, Catalina

“…Retinitis pigmentosa (RP) is a group of hereditary retinal neurodegenerative conditions characterized by primary dysfunction and death of photoreceptor cells,…”
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Proinsulin protects against age-related cognitive loss through anti-inflammatory convergent pathways by Corpas, Rubén, Hernández-Pinto, Alberto M., Porquet, David, Hernández-Sánchez, Catalina, Bosch, Fatima, Ortega-Aznar, Arantxa, Comellas, Francesc, de la Rosa, Enrique J., Sanfeliu, Coral

“…Brain inflammaging is increasingly considered as contributing to age-related cognitive loss and neurodegeneration. Despite intensive research in multiple…”
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Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale by Torras, Núria, Agusil, Juan Pablo, Vázquez, Patricia, Duch, Marta, Hernández-Pinto, Alberto M., Samitier, Josep, de la Rosa, Enrique J., Esteve, Jaume, Suárez, Teresa, Pérez-García, Lluïsa, Plaza, José A.

“…A novel suspended planar‐array chips technology is described, which effectively allows molecular multiplexing using a single suspended chip to analyze…”
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Microglia-Müller glia crosstalk in the rd10 mouse model of retinitis pigmentosa by Arroba, Ana I, Alvarez-Lindo, Noemí, van Rooijen, Nico, de la Rosa, Enrique J

“…Retinitis pigmentosa refers to a large, genetically heterogeneous group of retinal dystrophies. This condition is characterized by the gradual onset of…”
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The Prohormone Proinsulin as a Neuroprotective Factor: Past History and Future Prospects by de Pablo, Flora, Hernández-Sánchez, Catalina, de la Rosa, Enrique J

“…Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to…”
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Early neural cell death: numbers and cues from the developing neuroretina by Valenciano, Ana I, Boya, Patricia, de la Rosa, Enrique J

“…Programmed cell death is a well established key process required for proper development of the nervous system. The regulatory and executor mechanisms…”
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IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death by Arroba, Ana I., Wallace, Deborah, Mackey, Ashley, De La Rosa, Enrique J., Cotter, Thomas G.

“…Retinitis pigmentosa is a heterogeneous group of inherited retinal dystrophies in which the loss of photoreceptor cells via apoptosis leads to blindness. In…”
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Cell death in early neural development: beyond the neurotrophic theory by de la Rosa, Enrique J, de Pablo, Flora

“…The important effect of cell death on projecting neurons during development is well established. However, this mainstream research might have diverted…”
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