Search Results - "de la Rosa, Diego Alvarez"
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1
Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase
Published in Hypertension (Dallas, Tex. 1979) (01-07-2015)“…Metabolic syndrome is a major risk factor for the development of diabetes mellitus and cardiovascular diseases. Pharmacological antagonism of the…”
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2
SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms
Published in Neurobiology of disease (01-06-2021)“…Epilepsy is a neurological condition associated to significant brain damage produced by status epilepticus (SE) including neurodegeneration, gliosis and…”
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3
11β-HSD2 SUMOylation Modulates Cortisol-Induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation
Published in Endocrinology (Philadelphia) (01-11-2017)“…The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) has an essential role in aldosterone target tissues, conferring aldosterone selectivity for the…”
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4
Histone Deacetylase 6–Controlled Hsp90 Acetylation Significantly Alters Mineralocorticoid Receptor Subcellular Dynamics But Not its Transcriptional Activity
Published in Endocrinology (Philadelphia) (01-06-2016)“…The mineralocorticoid receptor (MR) is a member of the nuclear receptor superfamily that transduces the biological effects of corticosteroids. Its…”
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5
Effects of Chronic Kidney Disease on Nanomechanics of the Endothelial Glycocalyx Are Mediated by the Mineralocorticoid Receptor
Published in International journal of molecular sciences (13-09-2022)“…Endothelial mechanics control vascular reactivity and are regulated by the mineralocorticoid receptor (MR) and its downstream target, the epithelial Na channel…”
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6
Aldosterone-Specific Activation of Cardiomyocyte Mineralocorticoid Receptor In Vivo
Published in Hypertension (Dallas, Tex. 1979) (01-02-2013)“…Inappropriate mineralocorticoid receptor (MR) activation is involved in cardiac diseases. Whether and how aldosterone is involved in the deleterious effects of…”
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7
The diuretic torasemide does not prevent aldosterone-mediated mineralocorticoid receptor activation in cardiomyocytes
Published in PloS one (09-09-2013)“…Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid…”
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8
The Crucial Role of Chromogranins in Storage and Exocytosis Revealed Using Chromaffin Cells from Chromogranin A Null Mouse
Published in The Journal of neuroscience (26-03-2008)“…Chromogranins (Cgs) are the major soluble proteins of dense-core secretory vesicles. Chromaffin cells from Chga null mice [chromogranin A knock-out (CgA-KO)]…”
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9
Phenotypic Modulation of Cultured Primary Human Aortic Vascular Smooth Muscle Cells by Uremic Serum
Published in Frontiers in physiology (12-02-2018)“…Patients with chronic kidney disease (CKD) have a markedly increased incidence of cardiovascular disease (CVD). The high concentration of circulating uremic…”
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10
Multiple mineralocorticoid response elements localized in different introns regulate intermediate conductance K+ (Kcnn4) channel expression in the rat distal colon
Published in PloS one (05-06-2014)“…An elevated plasma aldosterone and an increased expression of the intermediate conductance K(+) (IK/Kcnn4) channels are linked in colon. This observation…”
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11
The neuronal serum- and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current
Published in The Journal of neuroscience (06-02-2013)“…The M-current formed by tetramerization of Kv7.2 and Kv7.3 subunits is a neuronal voltage-gated K(+) conductance that controls resting membrane potential and…”
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12
The dopamine transporter is differentially regulated after dopaminergic lesion
Published in Neurobiology of disease (01-12-2010)“…Abstract The dopamine transporter (DAT) is a transmembrane glycoprotein responsible for dopamine (DA) uptake, which has been shown to be involved in DA-cell…”
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13
Functional Implications of the Localization and Activity of Acid-Sensitive Channels in Rat Peripheral Nervous System
Published in Proceedings of the National Academy of Sciences - PNAS (19-02-2002)“…Acid-sensitive ion channels (ASIC) are proton-gated ion channels expressed in neurons of the mammalian central and peripheral nervous systems. The functional…”
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14
Molecular Components of Nitrate and Nitrite Efflux in Yeast
Published in Eukaryotic Cell (01-02-2014)“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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15
Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system
Published in The Journal of physiology (01-01-2003)“…The acid-sensitive ion channel ASIC1 is a proton-gated ion channel from the mammalian nervous system. Its expression in sensory neurons and activation by low…”
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16
Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC)
Published in Bioorganic & medicinal chemistry (01-07-2012)“…Epithelial Na+ channels (ENaCs) were heterologously expressed in Xenopus oocytes and exposed to garlic extract and its main compounds. Garlic extract and…”
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17
Structural and molecular determinants of mineralocorticoid receptor signalling
Published in British journal of pharmacology (01-07-2022)“…During the past decades, the mineralocorticoid receptor (MR) has evolved from a much‐overlooked member of the steroid hormone receptor family to an important…”
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18
Structure and regulation of amiloride-sensitive sodium channels
Published in Annual review of physiology (01-01-2000)“…Amiloride-sensitive Na+ channels constitute a new class of proteins known as the ENaC-Deg family of ion channels. All members in this family share a common…”
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19
Effects of aldosterone on biosynthesis, traffic, and functional expression of epithelial sodium channels in A6 cells
Published in The Journal of general physiology (01-05-2002)“…The collecting duct regulates Na(+) transport by adjusting the abundance/activity of epithelial Na(+) channels (ENaC). In this study we have investigated the…”
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20
Multiple translational isoforms give functional specificity to serum- and glucocorticoid-induced kinase 1
Published in Molecular biology of the cell (01-06-2007)“…Serum- and glucocorticoid-induced kinase 1 is a ubiquitous kinase that regulates diverse processes such as ion transport and cell survival. We report that a…”
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