Search Results - "de la Luz Sierra, Maria"

Lipoprotein particles in patients with pediatric Cushing disease and possible cardiovascular risks by Makri, Angeliki, Cheung, Anita, Sinaii, Ninet, Remaley, Alan T., Sampson, Maureen, Keil, Meg, Belyavskaya, Elena, Lyssikatos, Charalampos, De La Luz Sierra, Maria, Stratakis, Constantine A., Lodish, Maya

“…Background Cardiovascular (CV) complications are the most significant cause of mortality in adults with Cushing disease (CD); little is known about CV risk…”
Get full text

G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells by Kim, Hyun Kyung, De La Luz Sierra, Maria, Williams, Cassin Kimmel, Gulino, A. Virginia, Tosato, Giovanna

“…CXCR4 receptor expression is required for the retention of granulocyte precursors and mature neutrophils within the bone marrow, and disruption of the…”
Get full text

EphB2 and EphB4 receptors forward signaling promotes SDF-1–induced endothelial cell chemotaxis and branching remodeling by Salvucci, Ombretta, de la Luz Sierra, Maria, Martina, Jose A., McCormick, Peter J., Tosato, Giovanna

“…The complex molecular mechanisms that drive endothelial cell movement and the formation of new vessels are poorly understood and require further investigation…”
Get full text

The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1 by de la Luz Sierra, Maria, Sakakibara, Shuhei, Gasperini, Paola, Salvucci, Ombretta, Jiang, Kan, McCormick, Peter J., Segarra, Marta, Stone, Jim, Maric, Dragan, Zhu, Jinfang, Qian, Xiaolan, Lowy, Douglas R., Tosato, Giovanna

“…The transcription factor growth factor independence 1 (Gfi1) and the growth factor granulocyte colony-stimulating factor (G-CSF) are individually essential for…”
Get full text

Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth by Segarra, Marta, Williams, Cassin Kimmel, Sierra, Maria de la Luz, Bernardo, Marcelino, McCormick, Peter J., Maric, Dragan, Regino, Celeste, Choyke, Peter, Tosato, Giovanna

“…Gene targeting experiments have shown that Delta-like 4 (Dll4) is a vascular-specific Notch ligand critical to normal vascular development. Recent studies have…”
Get full text

Ovarian histology in children with classic galactosemia and correlation with endocrine and metabolic markers by Badger, Taylor, Kastury, Rama, Kavarthapu, Raghuveer, Balasubramanian, Ramya, De La Luz Sierra, Maria, Lou, Hong, Abbott, Craig, Yano, Jacqueline C., Gomez-Lobo, Veronica

Get full text

Novel Anti-Inflammatory Properties of the Angiogenesis Inhibitor Vasostatin by Huegel, Rainer, Velasco, Paula, De La Luz Sierra, Maria, Christophers, Enno, Schröder, Jens M., Schwarz, Thomas, Tosato, Giovanna, Lange-Asschenfeldt, Bernhard

“…Endothelial cells are critically involved in the pathogenesis of inflammation, which is characterized by vasopermeability, plasma leakage, leukocyte…”
Get full text

Pituitary Adenoma With Paraganglioma/Pheochromocytoma (3PAs) and Succinate Dehydrogenase Defects in Humans and Mice by Xekouki, Paraskevi, Szarek, Eva, Bullova, Petra, Giubellino, Alessio, Quezado, Martha, Mastroyannis, Spyridon A, Mastorakos, Panagiotis, Wassif, Christopher A, Raygada, Margarita, Rentia, Nadia, Dye, Louis, Cougnoux, Antony, Koziol, Deloris, Sierra, Maria de La Luz, Lyssikatos, Charalampos, Belyavskaya, Elena, Malchoff, Carl, Moline, Jessica, Eng, Charis, Maher, Louis James, Pacak, Karel, Lodish, Maya, Stratakis, Constantine A

“…Context: Germline mutations in genes coding succinate dehydrogenase (SDH) subunits A, B, C, and D have been identified in familial paragangliomas…”
Get full text

Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH? by Xekouki, Paraskevi, Pacak, Karel, Almeida, Madson, Wassif, Christopher A, Rustin, Pierre, Nesterova, Maria, de la Luz Sierra, Maria, Matro, Joey, Ball, Evan, Azevedo, Monalisa, Horvath, Anelia, Lyssikatos, Charalampos, Quezado, Martha, Patronas, Nicholas, Ferrando, Barbara, Pasini, Barbara, Lytras, Aristides, Tolis, George, Stratakis, Constantine A

“…Background: Mutations in the subunits B, C, and D of succinate dehydrogenase (SDH) mitochondrial complex II have been associated with the development of…”
Get full text

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function by Levy, Isaac, Szarek, Eva, Maria, Andrea Gutierrez, Starrost, Matthew, De La Luz Sierra, Maria, Faucz, Fabio R., Stratakis, Constantine A.

“…Phosphodiesterases catalyze the hydrolysis of cyclic nucleotides and maintain physiologic levels of intracellular concentrations of cyclic adenosine and…”
Get full text

Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis by Yao, Lei, Salvucci, Ombretta, Cardones, Adela R., Hwang, Sam T., Aoki, Yoshiyasu, De La Luz Sierra, Maria, Sajewicz, Agatha, Pittaluga, Stefania, Yarchoan, Robert, Tosato, Giovanna

“…Kaposi sarcoma (KS), the most common neoplasm in patients with AIDS, typically presents with multiple skin lesions characterized by “spindle cells,” the vast…”
Get full text

Functional characterization of two novel germline mutations of the KCNJ5 gene in hypertensive patients without primary aldosteronism but with ACTH-dependent aldosterone hypersecretion by Sertedaki, Amalia, Markou, Athina, Vlachakis, Dimitrios, Kossida, Sophia, Campanac, Emilie, Hoffman, Dax A., Sierra, Maria De La Luz, Xekouki, Paraskevi, Stratakis, Constantine A., Kaltsas, Gregory, Piaditis, George P., Chrousos, George P., Charmandari, Evangelia

“…Summary Background Germline mutations of the KCNJ5 gene encoding Kir3·4, a member of the inwardly rectifying K+ channel, have been identified in ‘normal’…”
Get full text

Differential processing of stromal-derived factor-1α and stromal-derived factor-1β explains functional diversity by De La Luz Sierra, Maria, Yang, Fuquan, Narazaki, Masashi, Salvucci, Ombretta, Davis, David, Yarchoan, Robert, Zhang, Hongwei H., Fales, Henry, Tosato, Giovanna

“…The chemokine stromal-derived factor-1 (SDF-1), which is constitutively expressed in most tissues as SDF-1α and SDF-1β resulting from alternative gene…”
Get full text

Differences in Adiposity in Cushing Syndrome Caused by PRKAR1A Mutations: Clues for the Role of Cyclic AMP Signaling in Obesity and Diagnostic Implications by London, Edra, Rothenbuhler, Anya, Lodish, Maya, Gourgari, Evgenia, Keil, Meg, Lyssikatos, Charalampos, de la Luz Sierra, Maria, Patronas, Nicolas, Nesterova, Maria, Stratakis, Constantine A

“…Context: The cAMP signaling pathway is implicated in bilateral adrenocortical hyperplasias. Bilateral adrenocortical hyperplasia is often associated with…”
Get full text

Single‐nucleus and spatial transcriptomics of paediatric ovary: Molecular insights into the dysregulated signalling pathways underlying premature ovarian insufficiency in classic galactosemia by Kavarthapu, Raghuveer, Lou, Hong, Pham, Thang, Do, Han, Soliman, Mary E., Badger, Taylor, Balasubramanian, Ramya, Huyhn, Victoria, De La Luz Sierra, Maria, Yano Maher, Jacqueline C., Gomez‐Lobo, Veronica

“…Background Classic galactosemia (CG) is an inborn error of galactose metabolism caused by mutations in the GALT gene. Premature ovarian insufficiency (POI) is…”
Get full text

Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells by De La Luz Sierra, Maria, Gasperini, Paola, McCormick, Peter J., Zhu, Jinfang, Tosato, Giovanna

“…The mechanisms underlying granulocyte-colony stimulating factor (G-CSF)–induced mobilization of granulocytic lineage cells from the bone marrow to the…”
Get full text

Familial pituitary apoplexy as the only presentation of a novel AIP mutation by Xekouki, Paraskevi, Mastroyiannis, Spyridon A, Avgeropoulos, Dimitrios, de la Luz Sierra, Maria, Trivellin, Giampaolo, Gourgari, Evgenia A, Lyssikatos, Charalampos, Quezado, Martha, Patronas, Nicholas, Kanaka-Gantenbein, Christina, Chrousos, George P, Stratakis, Constantine A

Get full text

KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome by Xekouki, Paraskevi, Hatch, Michael M, Lin, Lin, Rodrigo, De Alexandre, Azevedo, Monalisa, de la Luz Sierra, Maria, Levy, Isaac, Saloustros, Emmanouil, Moraitis, Andreas, Horvath, Anelia, Kebebew, E, Hoffman, Dax A, Stratakis, Constantine A

“…KCNJ5 mutations were recently described in primary hyperaldosteronism (PH or Conn's syndrome). The frequency of these mutations in PH and the way KCNJ5 defects…”
Get full text

Regulation of CXCR4 by the Notch Ligand Delta-like 4 in Endothelial Cells by WILLIAMS, Cassin Kimmel, SEGARRA, Marta, DE LA LUZ SIERRA, Maria, SAINSON, Richard C. A, TOSATO, Giovanna, HARRIS, Adrian L

“…Gene-targeting studies have shown that Delta-like 4 (Dll4) is required for normal embryonic vascular remodeling, but the mechanisms underlying Dll4 regulatory…”
Get full text

Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo by Villalba, Sabrina, Salvucci, Ombretta, Aoki, Yoshiyasu, Sierra, Maria De La Luz, Gupta, Ghanshyam, Davis, David, Wyvill, Kathleen, Little, Richard, Yarchoan, Robert, Tosato, Giovanna

“…The chemokine stromal‐derived factor‐1 (SDF‐1) can block human immunodeficiency virus type 1 (HIV‐1) infection in vitro by binding to the CXC chemokine…”
Get full text