Search Results - "de la Fuente, Miguel Á"

Succinate Dehydrogenase and Human Disease: Novel Insights into a Well-Known Enzyme by Esteban-Amo, María J, Jiménez-Cuadrado, Patricia, Serrano-Lorenzo, Pablo, de la Fuente, Miguel Á, Simarro, María

“…Succinate dehydrogenase (also known as complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the tricarboxylic…”
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WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP) by Fuente, Miguel A. de la, Sasahara, Yoji, Calamito, Marco, Antón, Inés M, Elkhal, Abdallah, Gallego, Maria D, Suresh, Koduru, Siminovitch, Katherine, Ochs, Hans D, Anderson, Kenneth C, Rosen, Fred S, Geha, Raif S, Ramesh, Narayanaswamy

“…Wiskott-Aldrich syndrome protein (WASP) is in a complex with WASP-interacting protein (WIP). WASP levels, but not mRNA levels, were severely diminished in T…”
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Systematic Analysis of FASTK Gene Family Alterations in Cancer by Magraner-Pardo, Lorena, Gobelli, Dino, de la Fuente, Miguel A, Pons, Tirso, Simarro, María

“…The FASTK family of proteins have been recently reported to play a key role in the post-transcriptional regulation of mitochondrial gene expression, including…”
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Development of a novel in vitro model to study the modulatory role of the respiratory complex I in macrophage effector functions by Serrano-Lorenzo, Pablo, Gobelli, Dino, Garrido-Moraga, Rocío, Esteban-Amo, María J, López-López, José R, Orduña, Antonio, de la Fuente, Miguel A, Martín, Miguel A, Simarro, María

“…Increasing evidence demonstrate that the electron transfer chain plays a critical role in controlling the effector functions of macrophages. In this work, we…”
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The mitochondrial succinate dehydrogenase complex controls the STAT3-IL-10 pathway in inflammatory macrophages by Gobelli, Dino, Serrano-Lorenzo, Pablo, Esteban-Amo, María J., Serna, Julia, Pérez-García, M. Teresa, Orduña, Antonio, Jourdain, Alexis A., Martín-Casanueva, Miguel Á., Á. de la Fuente, Miguel, Simarro, María

“…The functions of macrophages are tightly regulated by their metabolic state. However, the role of the mitochondrial electron transport chain (ETC) in…”
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The FASTK family of proteins: emerging regulators of mitochondrial RNA biology by Jourdain, Alexis A, Popow, Johannes, de la Fuente, Miguel A, Martinou, Jean-Claude, Anderson, Paul, Simarro, Maria

“…The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its…”
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Impact of Metabolism on Immune Responses by Elkhal, Abdallah, Rodriguez Cetina Biefer, Hector, de la Fuente, Miguel A.

“…H. Li et al. were able to show how intermittently high glucose potentiates activation and inflammatory responses through Toll-like receptor 4 and Th1 cells,…”
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Voltage‐dependent conformational changes of Kv1.3 channels activate cell proliferation by Cidad, Pilar, Alonso, Esperanza, Arévalo‐Martínez, Marycarmen, Calvo, Enrique, Fuente, Miguel A., Pérez‐García, M. Teresa, López‐López, José R.

“…The voltage‐dependent potassium channel Kv1.3 has been implicated in proliferation in many cell types, based on the observation that Kv1.3 blockers inhibited…”
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Characterization of endogenous Kv1.3 channel isoforms in T cells by Serna, Julia, Peraza, Diego A., Moreno‐Estar, Sara, Saez, Juan J., Gobelli, Dino, Simarro, Maria, Hivroz, Claire, López‐López, José R., Cidad, Pilar, Fuente, Miguel A., Pérez‐García, M. Teresa

“…Voltage‐dependent potassium channel Kv1.3 plays a key role on T‐cell activation; however, lack of reliable antibodies has prevented its accurate detection…”
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Novel fluorescent-based reporter cell line engineered for monitoring homologous recombination events by Bernardi, Alejandra, Gobelli, Dino, Serna, Julia, Nawrocka, Paulina, March-Rosselló, Gabriel, Orduña, Antonio, Kozlowski, Piotr, Simarro, María, de la Fuente, Miguel A

“…Homologous recombination (HR) faithfully restores DNA double-strand breaks. Defects in this HR repair pathway are associated with cancer predisposition. In…”
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Clinical exome analysis and targeted gene repair of the c.1354dupT variant in iPSC lines from patients with PROM1-related retinopathies exhibiting diverse phenotypes by Puertas-Neyra, Kevin, Coco-Martin, Rosa M, Hernandez-Rodriguez, Leticia A, Gobelli, Dino, Garcia-Ferrer, Yenisey, Palma-Vecino, Raicel, Tellería, Juan José, Simarro, Maria, de la Fuente, Miguel A, Fernandez-Bueno, Ivan

“…Inherited retinal dystrophies (IRD) are one of the main causes of incurable blindness worldwide. IRD are caused by mutations in genes that encode essential…”
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WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1α by Gallego, Maria Dolores, de la Fuente, Miguel A., Anton, Ines M., Snapper, Scott, Fuhlbrigge, Robert, Geha, Raif S.

“…Homing of lymphocytes to tissues is a biologically important multistep process that involves selectin-dependent rolling, integrin-dependent adhesion and…”
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Differential Role of SLP-76 Domains in T Cell Development and Function by Kumar, Lalit, Pivniouk, Vadim, de la Fuente, Miguel A., Laouini, Dhafer, Geha, Raif S.

“…The adapter SLP-76 is essential for thymocyte development. SLP-76-/-mice were reconstituted with SLP-76 deletion mutant transgenes to examine the role of…”
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WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function by Westerberg, Lisa S., de la Fuente, Miguel A., Wermeling, Fredrik, Ochs, Hans D., Karlsson, Mikael C.I., Snapper, Scott B., Notarangelo, Luigi D.

“…Development of hematopoietic cells depends on a dynamic actin cytoskeleton. Here we demonstrate that expression of the cytoskeletal regulator WASP, mutated in…”
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Mechanism of Recruitment of WASP to the Immunological Synapse and of Its Activation Following TCR Ligation by Sasahara, Yoji, Rachid, Rima, Byrne, Michael J., de la Fuente, Miguel A., Abraham, Robert T., Ramesh, Narayanaswamy, Geha, Raif S.

“…F-actin polymerization following engagement of the T cell receptor (TCR) is dependent on WASP and is critical for T cell activation. The link between TCR and…”
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Deletion of FAST (Fas-activated serine/threonine phosphoprotein) ameliorates immune complex arthritis in mice by Simarro, Maria, Chen, Mei, De la Fuente, Miguel A., Eiros, José M., Orduña, Antonio, Anderson, Paul

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3BP2 Deficiency Impairs the Response of B Cells, but Not T Cells, to Antigen Receptor Ligation by de la Fuente, Miguel A., Kumar, Lalit, Lu, Bao, Geha, Raif S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation by Simarro, Maria, Giannattasio, Giorgio, De la Fuente, Miguel A, Benarafa, Charaf, Subramanian, Kulandayan K, Ishizawar, Rumey, Balestrieri, Barbara, Andersson, Emma M, Luo, Hongbo R, Orduña, Antonio, Boyce, Joshua, Anderson, Paul

“…We generated Fas-activated serine threonine phosphoprotein (FAST)-deficient mice (FAST(-/-)) to study the in vivo role of FAST in immune system function. In a…”
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Reduced thymic output, cell cycle abnormalities, and increased apoptosis of T lymphocytes in patients with cartilage-hair hypoplasia by de la Fuente, Miguel A., MD, PhD, Recher, Mike, MD, Rider, Nicholas L., DO, Strauss, Kevin A., MD, Morton, D. Holmes, MD, Adair, Margaret, MD, Bonilla, Francisco A., MD, PhD, Ochs, Hans D., MD, Gelfand, Erwin W., MD, Pessach, Itai M., MD, PhD, Walter, Jolan E., MD, PhD, King, Alejandra, MD, Giliani, Silvia, PhD, Pai, Sung-Yun, MD, Notarangelo, Luigi D., MD

“…Background Cartilage-hair hypoplasia (CHH) is characterized by metaphyseal dysplasia, bone marrow failure, increased risk of malignancies, and a variable…”
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Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity by Fernández-Díaz, Cristina M, Merino, Beatriz, López-Acosta, José F, Cidad, Pilar, de la Fuente, Miguel A, Lobatón, Carmen D, Moreno, Alfredo, Leissring, Malcolm A, Perdomo, Germán, Cózar-Castellano, Irene

“…Inhibition of insulin-degrading enzyme (IDE) has been proposed as a possible therapeutic target for type 2 diabetes treatment. However, many aspects of IDE's…”
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