Search Results - "de la Cruz, Aida"

Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila by Hall, Dayna J, Grewal, Savraj S, de la Cruz, Aida Flor A, Edgar, Bruce A

“…The Ras-related GTPase, Rheb, regulates the growth of animal cells. Genetic and biochemical tests place Rheb upstream of the target of rapamycin (TOR) protein…”
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An essential cell cycle regulation gene causes hybrid inviability in Drosophila by Phadnis, Nitin, Baker, EmilyClare P., Cooper, Jacob C., Frizzell, Kimberly A., Hsieh, Emily, de la Cruz, Aida Flor A., Shendure, Jay, Kitzman, Jacob O., Malik, Harmit S.

“…Speciation, the process by which new biological species arise, involves the evolution of reproductive barriers, such as hybrid sterility or inviability between…”
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Stepwise Evolution of Essential Centromere Function in a Drosophila Neogene by Ross, Benjamin D., Rosin, Leah, Thomae, Andreas W., Hiatt, Mary Alice, Vermaak, Danielle, de la Cruz, Aida Flor A., Imhof, Axel, Mellone, Barbara G., Malik, Harmit S.

“…Evolutionarily young genes that serve essential functions represent a paradox; they must perform a function that either was not required until after their…”
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Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress by Icreverzi, Amalia, de la Cruz, Aida Flor, Van Voorhies, Wayne A., Edgar, Bruce A.

“…Drosophila cyclinD (CycD) is the single fly ortholog of the mammalian cyclin D1 and promotes both cell cycle progression and cellular growth. However, little…”
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Coordination of Growth and Cell Division in the Drosophila Wing by Neufeld, Thomas P, de la Cruz, Aida Flor A, Johnston, Laura A, Edgar, Bruce A

“…In most tissues, cell division is coordinated with increases in mass (i.e., growth). To understand this coordination, we altered rates of division in cell…”
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The Drosophila Cyclin D-Cdk4 complex promotes cellular growth by Datar, Sanjeev A., Jacobs, Henning W., de la Cruz, Aida Flor A., Lehner, Christian F., Edgar, Bruce A.

“…Mammalian cyclin D–Cdk4 complexes have been characterized as growth factor‐responsive cell cycle regulators. Their levels rise upon growth factor stimulation,…”
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Local Translation in Nervous System Pathologies by Gamarra, María, de la Cruz, Aida, Blanco-Urrejola, Maite, Baleriola, Jimena

“…Dendrites and axons can extend dozens to hundreds of centimeters away from the cell body so that a single neuron can sense and respond to thousands of stimuli…”
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Mammalian Cyclin D1/Cdk4 complexes induce cell growth in Drosophila by Datar, Sanjeev A., Galloni, Mireille, Cruz, Aida de la, Marti, Mark, Edgar, Bruce A., Frei, Christian

“…The Drosophila melanogaster cyclin dependent protein kinase complex CycD/Cdk4 has been shown to regulate cellular growth (accumulation of mass) as well as…”
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RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons by Blanco-Urrejola, Maite, Gaminde-Blasco, Adhara, Gamarra, María, de la Cruz, Aida, Vecino, Elena, Alberdi, Elena, Baleriola, Jimena

“…Cell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical…”
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Gametic specialization of centromeric histone paralogs in Drosophila virilis by Kursel, Lisa E, McConnell, Hannah, de la Cruz, Aida Flor A, Malik, Harmit S

“…In most eukaryotes, centromeric histone (CenH3) proteins mediate mitosis and meiosis and ensure epigenetic inheritance of centromere identity. We hypothesized…”
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Cyclin D does not provide essential Cdk4-independent functions in Drosophila by Emmerich, J, Meyer, C.A, de la Cruz, A.F. A, Edgar, B.A, Lehner, C.F

“…The three mammalian D-type cyclins are thought to promote progression through the G1 phase of the cell cycle as regulatory subunits of cyclin-dependent kinase…”
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Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress by Icreverzi, Amalia, Cruz, Aida Flor A., Walker, David W., Edgar, Bruce A.

“…Summary Mitochondrial dysfunction has been implicated in human diseases, including cancer, and proposed to accelerate aging. The Drosophila Cyclin‐dependent…”
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Flow cytometric analysis of Drosophila cells by de la Cruz, Aida Flor A, Edgar, Bruce A

“…Flow cytometry is a powerful technique that allows the researcher to measure fluorescence emissions on a per-cell basis, at multiple wavelengths, in…”
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Intrinsic Negative Cell Cycle Regulation Provided by PIP Box-and Cul4Cdt2-Mediated Destruction of E2f1 during S Phase by SHIBUTANI, Shusaku T, DE LA CRUZ, Aida Flor A, TRAN, Vuong, TURBYFILL, William J, REIS, Tania, EDGAR, Bruce A, DURONIO, Robert J

“…E2F transcription factors are key regulators of cell proliferation that are inhibited by pRb family tumor suppressors. pRb-independent modes of E2F inhibition…”
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THE USE OF TOCILIZUMAB AT A COMMUNITY HOSPITAL DURING THE COVID-19 PANDEMIC IN THE EPICENTER OF NORTHERN NEW JERSEY by Capo, Aida, Patel, Harshana, Rajaratnam, Nishan, Govil, Swati, Ibrahim, Mounir, de la Cruz, Aida

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Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis by Ardanaz, Carlos G, de la Cruz, Aida, Minhas, Paras S, Hernández-Martín, Nira, Pozo, Miguel Ángel, Valdecantos, M Pilar, Valverde, Ángela M, Villa-Valverde, Palmira, Elizalde-Horcada, Marcos, Puerta, Elena, Ramírez, María J, Ortega, Jorge E, Urbiola, Ainhoa, Ederra, Cristina, Ariz, Mikel, Ortiz-de-Solórzano, Carlos, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, Karsenty, Gerard, Brüning, Jens C, Solas, Maite

“…Astrocytes are considered an essential source of blood-borne glucose or its metabolites to neurons. Nonetheless, the necessity of the main astrocyte glucose…”
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Large modular proteins by NMR by McEvoy, Megan M, de la Cruz, Aida Flor A, Dahlquist, Frederick W

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A Double-Assurance Mechanism Controls Cell Cycle Exit upon Terminal Differentiation in Drosophila by Buttitta, Laura A., Katzaroff, Alexia J., Perez, Carissa L., de la Cruz, Aida, Edgar, Bruce A.

“…Terminal differentiation is often coupled with permanent exit from the cell cycle, yet it is unclear how cell proliferation is blocked in differentiated…”
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Intrinsic Negative Cell Cycle Regulation Provided by PIP Box- and Cul4 super(Cdt2)-Mediated Destruction of E2f1 during S Phase by Shibutani, Shusaku T, De la Cruz, Aida Flor A, Tran, Vuong, Turbyfill, William J, Reis, Tania, Edgar, Bruce A, Duronio, Robert J

“…E2F transcription factors are key regulators of cell proliferation that are inhibited by pRb family tumor suppressors. pRb-independent modes of E2F inhibition…”
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Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila by Datar, Sanjeev A, Galloni, Mireille, de la Cruz, Aida, Marti, Mark, Edgar, Bruce A, Frei, Christian

“…The Drosophila melanogaster cyclin dependent protein kinase complex CycD/Cdk4 has been shown to regulate cellular growth (accumulation of mass) as well as…”
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