Search Results - "de Wynter, E. A."

Haematopoietic repopulating activity in human cord blood CD133 quiescent cells by Boxall, S A, Cook, G P, Pearce, D, Bonnet, D, El-Sherbiny, Y M, Blundell, M P, Howe, S J, Leek, J P, Markham, A F, de Wynter, E A

“…We have demonstrated previously that cord blood CD133 + cells isolated in the G 0 phase of the cell cycle are highly enriched for haematopoietic stem cell…”
Get full text

CD34+AC133+ Cells Isolated from Cord Blood are Highly Enriched in Long‐Term Culture‐Initiating Cells, NOD/SCID‐Repopulating Cells and Dendritic Cell Progenitors by de Wynter, E. A., Buck, D., Hart, C., Heywood, R., Coutinho, L. H., Clayton, A., Rafferty, J. A., Burt, D., Guenechea, G., Bueren, J. A., Gagen, D., Fairbairn, L. J., Lord, B. I., Testa, N. G.

“…The AC133 antigen is a novel antigen selectively expressed on a subset of CD34+ cells in human fetal liver, bone marrow, and blood as demonstrated by flow…”
Get full text

Marker gene transfer into human haemopoietic cells using a herpesvirus saimiri-based vector by DOODY, G. M, LEEK, J. P, BALI, A. K, ENSSER, A, MARKHAM, A. F, DE WYNTER, E. A

“…Herpesvirus-based gene therapy vectors offer an attractive alternative to retroviral vectors because of their episomal nature and ability to accommodate large…”
Get full text

NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34+ cells expressing the CCR1 chemokine receptor by DE WYNTER, E. A, HEYWORTH, C. M, MUKAIDA, N, MATSUSHIMA, K, TESTA, N. G

“…Human haemopoietic stem and progenitor cells may be distinguished by the pattern of cell surface markers they display. The cells defined as 'stem' cells are…”
Get full text

Multicentre European study comparing selection techniques for the isolation of CD34+ cells by DE WYNTER, E. A, RYDER, D, LANZA, F, NADALI, G, JOHNSEN, H, DENNING-KENDALL, P, THING-MORTENSEN, B, SILVESTRI, F, TESTA, N. G

“…Primitive haemopoietic cells are required for studies in both the clinical and research fields and a number of systems have been developed to facilitate…”
Get full text

Mesenchymal stem cells from CD34− human umbilical cord blood by Lu, X., Alshemali, S., De Wynter, E. A., Dickinson, A. M.

“…Umbilical cord blood (UCB) is well known to be a rich source of stem cells especially for haematopoietic stem cells (HSCs). Recently, mesenchymal stem cells…”
Get full text

Dendritic cells infected with recombinant fowlpox virus vectors are potent and long-acting stimulators of transgene-specific class I restricted T lymphocyte activity by BROWN, M, ZHANG, Y, DERMINE, S, DE WYNTER, E. A, HART, C, KITCHENER, H, STERN, P. L, SKINNER, M. A, STACEY, S. N

“…The identification of dendritic cells (DC) as the major antigen-presenting cell type of the immune system, combined with the development of procedures for…”
Get full text

What is the future for cord blood stem cells? by DE WYNTER, E. A

“…Stem and progenitor cells are present in cord blood at a high frequency making these cells a major target population for experimental and clinical studies…”
Get full text

Recombinant human megakaryocyte growth and development factor (MGDF) increases the numbers of megakaryocyte progenitor cells to normal values in long-term bone marrow cultures of patients with AML in first remission by KASPER, C, SCHWARZER, A, DE WYNTER, E. A, CHANG, J, DEXTER, T. M, RYDER, D, TESTA, N. G

“…The megakaryopoietic potential in the bone marrow (BM) of patients in first remission after treatment for acute myelogenous leukaemia (AML) was investigated…”
Get full text

Interest of cord blood stem cells by de Wynter, E.A, Testa, N.G

“…Interest in cord blood stem cells was raised because of the possibility, now realised, of their use in clinical transplantation. The availability of only…”
Get full text

Properties of peripheral blood and cord blood stem cells by de Wynter, E.A., Emmerson, A.J.B., Testa, N.G.

“…Mobilized peripheral blood and cord blood are used for transplantation in adults and children. Currently methods which assess the engraftment potential of…”
Get full text

Differential Response of CD34+ Cells Isolated from Cord Blood and Bone Marrow to MIP‐1α and the Expression of MIP‐1α Receptors on These Immature Cells by de Wynter, E. A., Durig, J., Cross, M. A., Heyworth, C. M., Testa, N. G.

“…Macrophage inflammatory protein‐1 alpha (MIP‐1α) has been shown to have a role in the control of myeloid stem and progenitor cell proliferation. Recent…”
Get full text

A family with Papillon-Lefèvre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity by Meade, Josephine L., de Wynter, Erika A., Brett, Peter, Sharif, Saghira Malik, Woods, C. Geoffrey, Markham, Alexander F., Cook, Graham P.

“…Activation of granzyme B, a key cytolytic effector molecule of natural killer (NK) cells, requires removal of an N-terminal pro-domain. In mice, cathepsin C is…”
Get full text

Comparison of purity and enrichment of CD34+ cells from bone marrow, umbilical cord and peripheral blood (primed for apheresis) using five separation systems by de Wynter, E A, Coutinho, L H, Pei, X, Marsh, J C, Hows, J, Luft, T, Testa, N G

“…Interest in the isolation and characterization of primitive hemopoietic cells in both the clinical and research fields has rapidly increased. In parallel,…”
Get more information

Cord blood G(0) CD34+ cells have a thousand-fold higher capacity for generating progenitors in vitro than G(1) CD34+ cells by Summers, Y J, Heyworth, C M, de Wynter, E A, Chang, J, Testa, N G

“…We examined the functional differences between G(0) and G(1) cord blood CD34+ cells for up to 24 weeks in serum-free suspension culture, containing Flt-3…”
Get full text

Extensive Amplification of Single Cells from CD34+ Subpopulations in Umbilical Cord Blood and Identification of Long‐Term Culture‐Initiating Cells Present in Two Subsets by de Wynter, E. A., Nadali, G., Coutinho, L. H., Testa, N. G.

“…CD34+ cord blood cells were isolated with immunomagnetic beads and fractionated by fluorescence‐activated cell sorting (FACS) into three subpopulations:…”
Get full text

CCR1 chemokine receptor expression isolates erythroid from granulocyte-macrophage progenitors by de Wynter, Erika A., Heyworth, Clare M., Mukaida, Naofumi, Jaworska, Ewa, Weffort‐Santos, Almeriane, Matushima, Kouji, Testa, Nydia G.

“…Simple methods that separate progenitor cells of different hemopoietic lineages would facilitate studies on lineage commitment and differentiation. We used an…”
Get full text

Dose-escalating induction chemotherapy supported by lenograstim preceding high-dose consolidation chemotherapy for advanced breast cancer. Selection of the most acceptable regimen to induce maximal tumor response and investigation of the optimal time to collect peripheral blood progenitor cells for haematological rescue after high-dose consolidation chemotherapy by Van Hoef, M E, Baumann, I, Lange, C, Luft, T, de Wynter, E A, Ranson, M, Morgenstern, G R, Yvers, A, Dexter, T M, Testa, N G

“…In advanced breast cancer high-dose consolidation chemotherapy with haematological rescue has resulted in prolonged disease free and overall survival in a…”
Get more information

Timing of peripheral blood progenitor cell (PBPC) collections during recovery from chemotherapy supported by haematopoietic growth factor by Van Hoef, M E, Baumann, I, Lange, C, De Wynter, E A, Testa, N G, Howell, A

Get more information

Regulation of the proliferative potential of cord blood long-term culture-initiating cells (LTC-IC) by different stromal cell lines: implications for LTC-IC measurement by Nadali, G, de Wynter, EA, Perandin, F, Tavecchia, L, Vincenzi, C, Ambrosetti, A, Fornale, M, Perona, G, Pizzolo, G, Testa, NG

“…Department of Hematology, University of Verona, Italy. gnadali@borgoroma.univr.it BACKGROUND AND OBJECTIVE: Long-term culture-initiating cells (LTC-IC) are the…”
Get full text