Search Results - "de Winther, Menno P"

Transcriptional and epigenetic regulation of macrophages in atherosclerosis by Kuznetsova, Tatyana, Prange, Koen H. M., Glass, Christopher K., de Winther, Menno P. J.

“…Monocytes and macrophages provide defence against pathogens and danger signals. These cells respond to stimulation in a fast and stimulus-specific manner by…”
Get full text

Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice by Donners, Marjo M P C, Wolfs, Ine M J, Stöger, Lauran J, van der Vorst, Emiel P C, Pöttgens, Chantal C H, Heymans, Stephane, Schroen, Blanche, Gijbels, Marion J J, de Winther, Menno P J

“…microRNA-155 (miR155) is a central regulator of immune responses that is induced by inflammatory mediators. Although miR155 is considered to be a…”
Get full text

Wound administration of M2-polarized macrophages does not improve murine cutaneous healing responses by Jetten, Nadine, Roumans, Nadia, Gijbels, Marion J, Romano, Andrea, Post, Mark J, de Winther, Menno P J, van der Hulst, Rene R W J, Xanthoulea, Sofia

“…Macrophages play a crucial role in all stages of cutaneous wound healing responses and dysregulation of macrophage function can result in derailed wound…”
Get full text

Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites by Dekkers, Koen F, Neele, Annette E, Jukema, J Wouter, Heijmans, Bastiaan T, de Winther, Menno P J

“…Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and…”
Get full text

BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality by Boon, Mariëtte R, van den Berg, Sjoerd A A, Wang, Yanan, van den Bossche, Jan, Karkampouna, Sofia, Bauwens, Matthias, De Saint-Hubert, Marijke, van der Horst, Geertje, Vukicevic, Slobodan, de Winther, Menno P J, Havekes, Louis M, Jukema, J Wouter, Tamsma, Jouke T, van der Pluijm, Gabri, van Dijk, Ko Willems, Rensen, Patrick C N

“…Brown adipose tissue (BAT) dissipates energy stored in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat…”
Get full text

Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI by Rondeaux, Julie, Groussard, Déborah, Renet, Sylvanie, Tardif, Virginie, Dumesnil, Anaïs, Chu, Alphonse, Di Maria, Léa, Lemarcis, Théo, Valet, Manon, Henry, Jean-Paul, Badji, Zina, Vézier, Claire, Béziau-Gasnier, Delphine, Neele, Annette E., de Winther, Menno P. J., Guerrot, Dominique, Brand, Marjorie, Richard, Vincent, Durand, Eric, Brakenhielm, Ebba, Fraineau, Sylvain

“…Epigenetic regulation of histone H3K27 methylation has recently emerged as a key step during alternative immunoregulatory M2-like macrophage polarization;…”
Get full text

Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro by Allijn, Iris E, Vaessen, Stefan F C, Quarles van Ufford, Linda C, Beukelman, Kees J, de Winther, Menno P J, Storm, Gert, Schiffelers, Raymond M

“…Inflammation is an important therapeutic target. Due to their potency, steroidal drugs dominate the current treatment of inflammatory disorders. However,…”
Get full text

The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential by Ghiboub, Mohammed, Bell, Matthew, Sinkeviciute, Dovile, Prinjha, Rab K, de Winther, Menno P J, Harker, Nicola R, Tough, David F, de Jonge, Wouter J

“…SP140 is an epigenetic reader protein expressed predominantly in immune cells. GWAS studies have shown an association between single nucleotide polymorphisms…”
Get full text

Sexual dimorphism in atherosclerotic plaques of aged Ldlr -/- mice by Smit, Virginia, de Mol, Jill, Kleijn, Mireia N A Bernabé, Depuydt, Marie A C, de Winther, Menno P J, Bot, Ilze, Kuiper, Johan, Foks, Amanda C

“…Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized by lipid accumulation and immune cell…”
Get full text

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140 by Ghiboub, Mohammed, Koster, Jan, Craggs, Peter D, Li Yim, Andrew Y. F, Shillings, Anthony, Hutchinson, Sue, Bingham, Ryan P, Gatfield, Kelly, Hageman, Ishtu L, Yao, Gang, O'Keefe, Heather P, Coffin, Aaron, Patel, Amish, Sloan, Lisa A, Mitchell, Darren J, Hayhow, Thomas G, Lunven, Laurent, Watson, Robert J, Blunt, Christopher E, Harrison, Lee A, Bruton, Gordon, Kumar, Umesh, Hamer, Natalie, Spaull, John R, Zwijnenburg, Danny A, Welting, Olaf, Hakvoort, Theodorus B. M, te Velde, Anje A, van Limbergen, Johan, Henneman, Peter, Prinjha, Rab K, de Winther, Menno P. J, Harker, Nicola R, Tough, David F, de Jonge, Wouter J

“…Abstract Background SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in…”
Get full text

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo by Jetten, Nadine, Verbruggen, Sanne, Gijbels, Marion J., Post, Mark J., De Winther, Menno P. J., Donners, Marjo M. P. C.

“…Objective Macrophages show extreme heterogeneity and different subsets have been characterized by their activation route and their function. For instance,…”
Get full text

MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction During Acute Viral Myocarditis by Corsten, Maarten F, Papageorgiou, Anna, Verhesen, Wouter, Carai, Paolo, Lindow, Morten, Obad, Susanna, Summer, Georg, Coort, Susan L.M, Hazebroek, Mark, van Leeuwen, Rick, Gijbels, Marion J.J, Wijnands, Erwin, Biessen, Erik A.L, De Winther, Menno P.J, Stassen, Frank R.M, Carmeliet, Peter, Kauppinen, Sakari, Schroen, Blanche, Heymans, Stephane

“…RATIONALE:Viral myocarditis results from an adverse immune response to cardiotropic viruses, which causes irreversible myocyte destruction and heart failure in…”
Get full text

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice by Poels, Kikkie, van Leent, Mandy M T, Reiche, Myrthe E, Kusters, Pascal J H, Huveneers, Stephan, de Winther, Menno P J, Mulder, Willem J M, Lutgens, Esther, Seijkens, Tom T P

“…T cell-driven inflammation plays a critical role in the initiation and progression of atherosclerosis. The co-inhibitory protein Cytotoxic T-Lymphocyte…”
Get full text

Arginase-1 deficiency regulates arginine concentrations and NOS2-mediated NO production during endotoxemia by Wijnands, Karolina A P, Hoeksema, Marten A, Meesters, Dennis M, van den Akker, Nynke M S, Molin, Daniel G M, Briedé, Jacob J, Ghosh, Mitrajit, Köhler, S Eleonore, van Zandvoort, Marc A M J, de Winther, Menno P J, Buurman, Wim A, Lamers, Wouter H, Poeze, Martijn

“…Arginase-1 is an important component of the intricate mechanism regulating arginine availability during immune responses and nitric oxide synthase (NOS)…”
Get full text

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging? by van Beek, Adriaan A., Van den Bossche, Jan, Mastroberardino, Pier G., de Winther, Menno P.J., Leenen, Pieter J.M.

“…Aging is a complex process with an impact on essentially all organs. Declined cellular repair causes increased damage at genomic and proteomic levels upon…”
Get full text

Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy by Beldman, Thijs J, Malinova, Tsveta S, Desclos, Emilie, Grootemaat, Anita E, Misiak, Aresh L. S, van der Velden, Saskia, van Roomen, Cindy P. A. A, Beckers, Linda, van Veen, Henk A, Krawczyk, Przemyslaw M, Hoebe, Ron A, Sluimer, Judith C, Neele, Annette E, de Winther, Menno P. J, van der Wel, Nicole N, Lutgens, Esther, Mulder, Willem J. M, Huveneers, Stephan, Kluza, Ewelina

“…Atherosclerosis is associated with a compromised endothelial barrier, facilitating the accumulation of immune cells and macromolecules in atherosclerotic…”
Get full text

Epigenetic Regulation of Monocyte and Macrophage Function by Hoeksema, Marten A, de Winther, Menno P J

“…Monocytes and macrophages are key players in tissue homeostasis and immune responses. Epigenetic processes tightly regulate cellular functioning in health and…”
Get more information

Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis by Beldman, Thijs J, Senders, Max L, Alaarg, Amr, Pérez-Medina, Carlos, Tang, Jun, Zhao, Yiming, Fay, Francois, Deichmöller, Jacqueline, Born, Benjamin, Desclos, Emilie, van der Wel, Nicole N, Hoebe, Ron A, Kohen, Fortune, Kartvelishvily, Elena, Neeman, Michal, Reiner, Thomas, Calcagno, Claudia, Fayad, Zahi A, de Winther, Menno P. J, Lutgens, Esther, Mulder, Willem J. M, Kluza, Ewelina

“…Hyaluronan is a biologically active polymer, which can be formulated into nanoparticles. In our study, we aimed to probe atherosclerosis-associated…”
Get full text

Local delivery of polarized macrophages improves reperfusion recovery in a mouse hind limb ischemia model by Jetten, Nadine, Donners, Marjo M P C, Wagenaar, Allard, Cleutjens, Jack P M, van Rooijen, Nico, de Winther, Menno P J, Post, Mark J

“…Enhancement of collateral development in coronary or peripheral artery disease is a therapeutic target, but it has proven difficult to achieve. Macrophages are…”
Get full text

Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice by Xanthoulea, Sofia, Thelen, Melanie, Pöttgens, Chantal, Gijbels, Marion J J, Lutgens, Esther, de Winther, Menno P J

“…The aim of the current study was to investigate the role of p55 TNF Receptor (p55 TNFR), the main signaling receptor for the pro-inflammatory cytokine tumor…”
Get full text