Search Results - "de Winther, M.P.J"

Disruption of the Cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation by LUTGENS, E, LUTGENS, S. P. M, FISHER, A, LONG, C. J, SAFTIG, P, BLACK, D, DAEMEN, M. J. A. P, CLEUTJENS, K. B. J. M, FABER, B. C. G, HEENEMAN, S, GIJBELS, M. M. J, DE WINTHER, M. P. J, FREDERIK, P, VAN DER MADE, I, DAUGHERTY, A, SIJBERS, A. M

“…Cathepsin K (catK), a lysosomal cysteine protease, was identified in a gene-profiling experiment that compared human early plaques, advanced stable plaques,…”
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Epigenetic control through histone modifications regulates macrophages during atherosclerosis by Neele, A.E, Van den Bossche, J, Hoeksema, M.A, de Winther, M.P.J

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Targeting Hdac3 limits foam cell formation and improves atherosclerotic plaque stability by Van den Bossche, J, Hoeksema, M.A, Gijbels, M.J.J, van der Velden, S, Sijm, A, Neele, A.E, Seijkens, T, Meiler, S, Boshuizen, M.C.S, Boon, L, Mullican, S.E, Spann, N.J, Dallinga-Thie, G.M, Cleutjens, J.P, Lazar, M.A, de Vries, C.J, Biessen, E.A.L, Daemen, M.J.A.P, Lutgens, E, de Winther, M.P.J

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The polycomb repressive complex 2 (PRC2) in macrophages and atherosclerosis by Neele, A.E., Willemsen, L., Chen, H.-J., Gijbels, M.J.J., Roomen, C.P.A.A., Griffith, G.R., Van Der Velden, S., Hoeksema, M.A., Prange, K.H.M., Boshuizen, M.C., Van Den Bossche, J., Tool, A.T., Matlung, H.L., Van Den Berg, T.K., Lutgens, E., De Winther, M.P.J.

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Histone methyltransferase DOT1L regulates macrophage inflammatory responses and lipid metabolism by Willemsen, L., Neele, A.E., Prange, K.H.M., Roomen, C.P.A.A., Bruinenberg, D. A.M. Lotgerink, Den Toom, M., Griffith, G.R., Chen, H.-J., Beckers, L., Bosmans, L.A., Binder, C.J., Van Leeuwen, F., Jacobs, H., De Winther, M.P.J.

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Single Cell Rna-Sequencing Identifies Numerous Cell Sub-Types And Suggests Lineage Plasticity In Human Atherosclerotic Plaques by Mokry, M., Depuydt, M.A.C., Prange, K.H.M., Slenders, L., Elbersen, D., Granneman, L.E.C., de Jager, S.C.A., Slütter, B.A., Bot, I., de Winther, M.P.J., Kuiper, J., Asselbergs, F.W., van der Laan, S.W., Pasterkamp, G.

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Microanatomy Of Advanced Human Atherosclerotic Plaques Through Single-Cell Transcriptomics by Depuydt, M., Prange, K.H.M., Slenders, L., Elbersen, D., Boltjes, A., de Jager, S.C.A., Slütter, B.A., Bot, I., van der Laan, S.W., Mokry, M., Pasterkamp, G., de Winther, M.P.J., Kuiper, J.

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Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice by van den Berg, S M, Seijkens, T T P, Kusters, P J H, Zarzycka, B, Beckers, L, den Toom, M, Gijbels, M J J, Chatzigeorgiou, A, Weber, C, de Winther, M P J, Chavakis, T, Nicolaes, G A F, Lutgens, E

“…Background: Immune processes contribute to the development of obesity and its complications, such as insulin resistance, type 2 diabetes mellitus and…”
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Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state by Bosmans, Laura A, van Tiel, Claudia M, Aarts, Suzanne A B M, Willemsen, Lisa, Baardman, Jeroen, van Os, Bram W, Toom, Myrthe den, Beckers, Linda, Ahern, David J, Levels, Johannes H M, Jongejan, Aldo, Moerland, Perry D, Verberk, Sanne G S, den Bossche, Jan van, de Winther, Menno M P J, Weber, Christian, Atzler, Dorothee, Monaco, Claudia, Gerdes, Norbert, Shami, Annelie, Lutgens, Esther

“…Abstract Aims CD40 and its ligand, CD40L, play a critical role in driving atherosclerotic plaque development. Disrupted CD40-signalling reduces experimental…”
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Leukocyte CD40L deficiency affects the CD25 + CD4 T cell population but does not affect atherosclerosis by Smook, M.L.F., Heeringa, P., Damoiseaux, J.G.M.C., Daemen, M.J.A.P., de Winther, M.P.J., Gijbels, M.J.J., Beckers, L., Lutgens, E., Cohen Tervaert, J.W.

“…Inhibition of CD40–CD40L interactions results in a reduction of innate regulatory T cells (Tregs) in CD40 −/− mice and induces a stable plaque phenotype in…”
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Spatial correlation of trace elements with morphological features of atherosclerotic plaques by Roijers, R.B., Dutta, R.K., Mutsaers, P.H.A., Gijbels, M.J.J., de Winther, M.P.J., de Goeij, J.J.M., van der Vusse, G.J.

“…A method is presented to correlate spatially trace elements with morphological features of atherosclerotic plaques by combining microprobe techniques and…”
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The effect of scavenger receptor A1 (SRA1) on arterosclerosis by de Winther, M.P.J., Kanters, E., Gijbels, M.J.J., van Dijk, K.W., van Vlijmen, B.J.M., Kraal, G., Hofker, M.H.

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Macrophage specific overexpression of the human macrophage scavenger receptor, using A 180 kb yeast artificial chromosome, reduces atherosclerosis in low density lipoprotein deficient mice by De Winther, M.P.J., van Dijk, K. Willems, Havekes, L.M., Hofker, M.H.

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Apolipophorin III levels in Locusta migratoria. Developmental regulation of gene expression and hemolymph protein concentration by De Winther, Menno P.J., Weers, Paul M.M., Bogerd, Jan, Van Der Horst, Dick J.

“…Apolipophorin III (apoLp-III) plays a key role in lipid mobilization during prolonged flight of the migratory locust, Locusta migratoria. In larval animals,…”
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Tu-P7:181 Hematopoietic deficiency of P55 TNF receptor negatively regulates plasma lipid levels and results in smaller atherosclerotic lesions by Xanthoulea, S., Ambagts, T., Gijbels, M.J.J., Van Der Made, I., Hofker, M.H., De Winther, M.P.J.

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W12-IS-001 The role of NF-icB in atherosclerosis by Hofkert, M.H., Kanterss, E., Gijbelst, M.J.J., Van der Made, I., Vergouwet, M., Pasparakis, M., Heeringa, P., Kraals, G., de Winther, M.P.J.

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