Search Results - "de Winter, Brenda"

Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial by Ewoldt, Tim M. J., Abdulla, Alan, Rietdijk, Wim J. R., Muller, Anouk E., de Winter, Brenda C. M., Hunfeld, Nicole G. M., Purmer, Ilse M., van Vliet, Peter, Wils, Evert-Jan, Haringman, Jasper, Draisma, Annelies, Rijpstra, Tom A., Karakus, Attila, Gommers, Diederik, Endeman, Henrik, Koch, Birgit C. P.

“…Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-lactam antibiotics and ciprofloxacin has been proposed as an…”
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Clinical applications of population pharmacokinetic models of antibiotics: Challenges and perspectives by de Velde, Femke, Mouton, Johan W., de Winter, Brenda C.M., van Gelder, Teun, Koch, Birgit C.P.

“…[Display omitted] Because of increasing antimicrobial resistance and the shortage of new antibiotics, there is a growing need to optimize the use of old and…”
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Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19 by Lemaitre, Florian, Budde, Klemens, Van Gelder, Teun, Bergan, Stein, Lawson, Roland, Noceti, Ofelia, Venkataramanan, Raman, Elens, Laure, Moes, Dirk Jan A. R., Hesselink, Dennis A., Pawinski, Tomasz, Johnson-Davis, Kamisha L., De Winter, Brenda C. M., Pattanaik, Smita, Brunet, Mercè, Masuda, Satohiro, Langman, Loralie J.

“…Nirmatrelvir/ritonavir (Paxlovid) consists of a peptidomimetic inhibitor (nirmatrelvir) of the SARS-CoV-2 main protease and a pharmacokinetic enhancer…”
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Should we abandon therapeutic drug monitoring of tacrolimus in whole blood and move to intracellular concentration measurements? by Udomkarnjananun, Suwasin, Eiamsitrakoon, Thanee, de Winter, Brenda C. M., van Gelder, Teun, Hesselink, Dennis A.

“…The measurement of whole blood (WB) concentrations has been the primary method for therapeutic drug monitoring of tacrolimus since its introduction in the…”
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Health-related Quality of Life and Fatigue in Liver Transplant Recipients Receiving Tacrolimus Versus Sirolimus-based Immunosuppression: Results From a Randomized Trial by Mulder, Midas B., Busschbach, Jan van, van Hoek, Bart, van den Berg, Aad P., Polak, Wojtek G., Alwayn, Ian P.J., de Winter, Brenda de C.M., Verhey-Hart, Elke, Erler, Nicole S., den Hoed, Caroline M., Metselaar, Herold J.

“…The impact of different immunosuppression regimes on the health-related quality of life (HRQoL) and the severity of fatigue in liver transplant recipients is…”
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Health-related Quality of Life and Fatigue in Liver Transplant Recipients Receiving Tacrolimus Versus Sirolimus-based Immunosuppression: Results From a Randomized Trial by Mulder, Midas B, Busschbach, Jan van, van Hoek, Bart, van den Berg, Aad P, Polak, Wojtek G, Alwayn, Ian P J, de Winter, Brenda de C M, Verhey-Hart, Elke, Erler, Nicole S, den Hoed, Caroline M, Metselaar, Herold J

“…The impact of different immunosuppression regimes on the health-related quality of life (HRQoL) and the severity of fatigue in liver transplant recipients is…”
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Pharmacokinetic and pharmacodynamic properties of polymyxin B in Escherichia coli and Klebsiella pneumoniae murine infection models by van der Meijden, Aart, Aranzana-Climent, Vincent, van der Spek, Heleen, de Winter, Brenda C M, Couet, William, Meletiadis, Joseph, Muller, Anouk E, van den Berg, Sanne

“…Abstract Background Although polymyxin B has been in use since the late 1950s, there have been limited studies done to unravel its pharmacokinetics (PK) and…”
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Towards optimizing cefepime/tazobactam (WCK 4282) exposure to achieve efficacy against piperacillin/tazobactam-resistant ESBL infections: dose recommendations for various renal functions, including intermittent haemodialysis, in healthy individuals by Muller, Anouk E, De Winter, Brenda C M, Koch, Birgit C P

“…WCK 4282 is a novel combination of cefepime 2 g and tazobactam 2 g being developed for the treatment of infections caused by piperacillin/tazobactam-resistant…”
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Non-linear absorption pharmacokinetics of amoxicillin: consequences for dosing regimens and clinical breakpoints by de Velde, Femke, de Winter, Brenda C M, Koch, Birgit C P, van Gelder, Teun, Mouton, Johan W

“…To describe the population pharmacokinetics of oral amoxicillin and to compare the PTA of current dosing regimens. Two groups, each with 14 healthy male…”
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Population pharmacokinetics and target attainment of ciprofloxacin in critically ill patients by Abdulla, Alan, Rogouti, Omar, Hunfeld, Nicole G. M., Endeman, Henrik, Dijkstra, Annemieke, van Gelder, Teun, Muller, Anouk E., de Winter, Brenda C. M., Koch, Birgit C. P.

“…Purpose To develop and validate a population pharmacokinetic model of ciprofloxacin intravenously in critically ill patients, and determine target attainment…”
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Therapeutic Drug Monitoring of Antibiotics in Critically Ill Patients: Current Practice and Future Perspectives With a Focus on Clinical Outcome by Koch, Birgit C. P., Muller, Anouk E., Hunfeld, Nicole G. M., de Winter, Brenda C.M., Ewoldt, Tim M. J., Abdulla, Alan, Endeman, Henrik

“…Early initiation of antibiotics is essential for ameliorating infections in critically ill patients. The correct dosage of antibiotics is imperative to ensure…”
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Model-Based Tacrolimus Follow-up Dosing in Adult Renal Transplant Recipients: A Simulation Trial by Francke, Marith I., Hesselink, Dennis A., Andrews, Louise M., van Gelder, Teun, Keizer, Ron J., de Winter, Brenda C. M.

“…Initial algorithm-based dosing appears to be effective in predicting tacrolimus dose requirement. However, achieving and maintaining the target concentrations…”
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Usage of Tacrolimus and Mycophenolic Acid During Conception, Pregnancy, and Lactation, and Its Implications for Therapeutic Drug Monitoring: A Systematic Critical Review by Le, Hoang Lan, Francke, Marith I., Andrews, Louise M., de Winter, Brenda C. M., van Gelder, Teun, Hesselink, Dennis A.

“…Conception, pregnancy, and lactation following solid organ transplantation require appropriate management. The most frequently used immunosuppressive drug…”
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Pharmacodynamics of Temocillin in Neutropenic Murine Infection Models by Muller, Anouk E, Raaphorst, Merel, van der Meijden, Aart, de Winter, Brenda C M, Meletiadis, Joseph, van den Berg, Sanne

“…Temocillin is used for the treatment of various infections caused by . The pharmacokinetic (PK)/pharmacodynamic (PD) index that is best correlated with the…”
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Best Practices to Implement Dried Blood Spot Sampling for Therapeutic Drug Monitoring in Clinical Practice by Francke, Marith I., Peeters, Laura E. J., Hesselink, Dennis A., Kloosterboer, Sanne M., Koch, Birgit C. P., Veenhof, Herman, de Winter, Brenda C. M.

“…Sampling of blood at home to determine the concentration of drugs or other compounds can be effective in limiting hospital-based sampling. This could lower…”
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A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus for Tunisian Adults after Renal Transplantation by Abderahmene, Amani, Francke, Marith I, Andrews, Louise M, Hesselink, Dennis A, Amor, Dorra, Sahtout, Wissal, Ajmi, Marwa, Mastouri, Hayfa, Bouslama, Ali, Zellama, Dorsaf, Omezzine, Asma, De Winter, Brenda C M

“…Tacrolimus is the most frequently used immunosuppressive drug for preventing renal rejection. However, its use is hampered by its narrow therapeutic index and…”
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Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology by Udomkarnjananun, Suwasin, Francke, Marith I., De Winter, Brenda C.M., Mulder, Midas B., Baan, Carla C., Metselaar, Herold J., den Hoed, Caroline M., Hesselink, Dennis A.

“…Immunosuppressive drugs have been key to the success of liver transplantation and are essential components of the treatment of inflammatory bowel disease (IBD)…”
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Pharmacokinetics and pharmacogenetics of high-dose methotrexate in Chinese adult patients with non-Hodgkin lymphoma: a population analysis by Yang, Lin, Wu, Hui, de Winter, Brenda C. M., Sheng, Chang-cheng, Qiu, Hong-qiang, Cheng, Yu, Chen, Juan, Zhao, Qiu-ling, Huang, Jing, Jiao, Zheng, Xie, Rui-xiang

“…Purpose High-dose methotrexate (HD-MTX) is widely used in the treatment of non-Hodgkin lymphoma (NHL), but the pharmacokinetic properties of HD-MTX in Chinese…”
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Development and Validation of Hematocrit Level Measurement in Dried Blood Spots Using Near-Infrared Spectroscopy by van de Velde, Daan, van der Graaf, Jordy L., Boussaidi, Mariam, Huisman, Ruud, Hesselink, Dennis A., Russcher, Henk, Kooij-Egas, Annelies C., van Maarseveen, Erik, de Winter, Brenda C.M.

“…Dried blood spots (DBSs) have gained recent popularity as a sampling method for therapeutic drug monitoring. For patients, DBS sampling has several advantages…”
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P-glycoprotein, FK-binding Protein-12, and the Intracellular Tacrolimus Concentration in T-lymphocytes and Monocytes of Kidney Transplant Recipients by Udomkarnjananun, Suwasin, Francke, Marith I., Dieterich, Marjolein, van De Velde, Daan, Litjens, Nicolle H.R., Boer, Karin, De Winter, Brenda C.M., Baan, Carla C., Hesselink, Dennis A.

“… Transplant recipients may develop rejection despite having adequate tacrolimus whole blood predose concentrations (C 0 ). The intra-immune cellular…”
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