Search Results - "de Wildt, S"

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group by Brouwer, KLR, Aleksunes, LM, Brandys, B, Giacoia, GP, Knipp, G, Lukacova, V, Meibohm, B, Nigam, SK, Rieder, M, de Wildt, SN

“…The critical importance of membrane‐bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in…”
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Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species by van Groen, B D, Nicolaï, J, Kuik, A C, Van Cruchten, S, van Peer, E, Smits, A, Schmidt, S, de Wildt, S N, Allegaert, K, De Schaepdrijver, L, Annaert, P, Badée, J

“…The liver represents a major eliminating and detoxifying organ, determining exposure to endogenous compounds, drugs, and other xenobiotics. Drug transporters…”
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Willingness-to-use and preferences for model-informed antenatal doses: a cross-sectional study among European healthcare practitioners and pregnant women by Koldeweij, C J M, Dibbets, A C, Ceulemans, M, de Vries, L C, Franklin, B D, Scheepers, H C J, de Wildt, S N

“…Physiological changes in pregnancy may affect drug safety and efficacy, sometimes requiring dose adjustments. Pregnancy-adjusted doses, however, are missing…”
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Microdosing and Other Phase 0 Clinical Trials: Facilitating Translation in Drug Development by Burt, T, Yoshida, K, Lappin, G, Vuong, L, John, C, Wildt, SN, Sugiyama, Y, Rowland, M

“…A number of drivers and developments suggest that microdosing and other phase 0 applications will experience increased utilization in the near-to-medium…”
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Pharmacotherapy in neonatal and pediatric extracorporeal membrane oxygenation (ECMO) by Wildschut, E D, Ahsman, M J, Houmes, R J, Pokorna, P, de Wildt, S N, Mathot, R A A, Tibboel, D

“…ECMO support is an established life saving therapy for potentially reversible respiratory and/or cardiac failure. Improvement of outcome depends on effective…”
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Glucuronidation in humans : Pharmacogenetic and developmental aspects by DE WILDT, S. N, KEARNS, G. L, LEEDER, J. S, VAN DEN ANKER, J. N

“…During human development impressive changes in drug disposition occur. An important determinant of drug clearance is metabolism, something that is not only…”
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Pharmacokinetics and metabolism of intravenous midazolam in preterm infants by de Wildt, S

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Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future by Darwich, A S, Ogungbenro, K, Vinks, A A, Powell, J R, Reny, J‐L, Marsousi, N, Daali, Y, Fairman, D, Cook, J, Lesko, L J, McCune, J S, Knibbe, C A J, Wildt, S N, Leeder, J S, Neely, M, Zuppa, A F, Vicini, P, Aarons, L, Johnson, T N, Boiani, J, Rostami‐Hodjegan, A

“…Patient groups prone to polypharmacy and special subpopulations are susceptible to suboptimal treatment. Refined dosing in special populations is imperative to…”
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Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients by de Wildt, S N, de Hoog, M, Vinks, A A, van der Giesen, E, van den Anker, J N

“…OBJECTIVETo determine the pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. DESIGNProspective population pharmacokinetic…”
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Protocolized post-operative pain management in infants; do we stick to it? by Ceelie, I., de Wildt, S.N., de Jong, M., Ista, E., Tibboel, D., van Dijk, M.

“…Background The American Academy of Pediatrics states that ongoing assessment of pain is essential for adequate pain treatment. Pain assessment by means of the…”
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Feasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation by Wildschut, E. D., Hanekamp, M. N., Vet, N. J., Houmes, R. J., Ahsman, M. J., Mathot, R. A. A., de Wildt, S. N., Tibboel, D.

“…Purpose In most extracorporeal membrane oxygenation (ECMO) centers patients are heavily sedated to prevent accidental decannulation and bleeding complications…”
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Nephrotoxicity of concomitant piperacillin/tazobactam and teicoplanin compared with monotherapy by Workum, J D, Kramers, C, Kolwijck, E, Schouten, J A, de Wildt, S N, Brüggemann, R J

“…Piperacillin/tazobactam combined with vancomycin has been associated with a decline in renal function when compared with monotherapy. Teicoplanin is a…”
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Pharmacokinetics and metabolism of oral midazolam in preterm infants by De Wildt, S. N., Kearns, G. L., Hop, W. C. J., Murry, D. J., Abdel‐Rahman, S. M., Van Den Anker, J. N.

“…Aims  To characterize the pharmacokinetics and metabolism of oral midazolam in 15 preterm infants. Methods  After an oral dose (0.1 mg kg−1), blood was drawn…”
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Developmental patterns in human blood–brain barrier and blood–cerebrospinal fluid barrier ABC drug transporter expression by Verscheijden, L. F. M., van Hattem, A. C., Pertijs, J. C. L. M., de Jongh, C. A., Verdijk, R. M., Smeets, B., Koenderink, J. B., Russel, F. G. M., de Wildt, S. N.

“…When drugs exert their effects in the brain, linear extrapolation of doses from adults could be harmful for children as the blood–brain barrier (BBB) and…”
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Cytochrome P450 3A: Ontogeny and drug disposition by DE WILDT, S. N, KEARNS, G. L, LEEDER, J. S, VAN DEN ANKER, J. N

“…The maturation of organ systems during fetal life and childhood exerts a profound effect on drug disposition. The maturation of drug-metabolising enzymes is…”
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Pediatric microdose and microtracer studies using 14C in Europe by Turner, MA, Mooij, MG, Vaes, WHJ, Windhorst, AD, Hendrikse, NH, Knibbe, CAJ, Kõrgvee, LT, Maruszak, W, Grynkiewicz, G, Garner, RC, Tibboel, D, Park, BK, de Wildt, SN

“…Important information gaps remain on the efficacy and safety of drugs in children. Pediatric drug development encounters several ethical, practical, and…”
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The COMFORT behaviour scale detects clinically meaningful effects of analgesic and sedative treatment by Boerlage, A.A., Ista, E., Duivenvoorden, H.J., de Wildt, S.N., Tibboel, D., van Dijk, M.

“…Background The COMFORT behaviour scale (COMFORT‐B scale) is widely used in paediatric intensive care units to assess young children's pain and distress. It is…”
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Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants by Mooij, Miriam G, de Koning, Barbara E A, Lindenbergh-Kortleve, Dicky J, Simons-Oosterhuis, Ytje, van Groen, Bianca D, Tibboel, Dick, Samsom, Janneke N, de Wildt, Saskia N

“…The intestinal influx oligopeptide transporter peptide transporter 1 (PEPT1) (SLC15A1) is best known for nutrient-derived di- and tripeptide transport. Its…”
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Adverse events of haloperidol for the treatment of delirium in critically ill children by Slooff, V. D., Spaans, E., van Puijenbroek, E., Jessurun, N., van Beusekom, B. S., de Hoog, M., Tibboel, D., de Wildt, S. N.

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The CYP3A43 Allele: Is it really rare? by VAN SCHAIK, Ron H. N, DE WILDT, Saskia N, BROSENS, Rebecca, LINDEMANS, Jan, VAN DEN ANKER, John N, VAN FESSEM, Marianne

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