Search Results - "de Wilde, Adriaan H"

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis by Snijder, Eric J, Limpens, Ronald W A L, de Wilde, Adriaan H, de Jong, Anja W M, Zevenhoven-Dobbe, Jessika C, Maier, Helena J, Faas, Frank F G A, Koster, Abraham J, Bárcena, Montserrat

“…Zoonotic coronavirus (CoV) infections, such as those responsible for the current severe acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave…”
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Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses by Bos, Rinke, Rutten, Lucy, van der Lubbe, Joan E. M., Bakkers, Mark J. G., Hardenberg, Gijs, Wegmann, Frank, Zuijdgeest, David, de Wilde, Adriaan H., Koornneef, Annemart, Verwilligen, Annemiek, van Manen, Danielle, Kwaks, Ted, Vogels, Ronald, Dalebout, Tim J., Myeni, Sebenzile K., Kikkert, Marjolein, Snijder, Eric J., Li, Zhenfeng, Barouch, Dan H., Vellinga, Jort, Langedijk, Johannes P. M., Zahn, Roland C., Custers, Jerome, Schuitemaker, Hanneke

“…Development of effective preventative interventions against SARS-CoV-2, the etiologic agent of COVID-19 is urgently needed. The viral surface spike (S) protein…”
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Cyclosporin A inhibits the replication of diverse coronaviruses by de Wilde, Adriaan H, Zevenhoven-Dobbe, Jessika C, van der Meer, Yvonne, Thiel, Volker, Narayanan, Krishna, Makino, Shinji, Snijder, Eric J, van Hemert, Martijn J

“…Low micromolar, non-cytotoxic concentrations of cyclosporin A (CsA) strongly affected the replication of severe acute respiratory syndrome coronavirus…”
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Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture by DE WILDE, Adriaan H, JOCHMANS, Dirk, POSTHUMA, Clara C, ZEVENHOVEN-DOBBE, Jessika C, VAN NIEUWKOOP, Stefan, BESTEBROER, Theo M, VAN DEN HOOGEN, Bernadette G, NEYTS, Johan, SNIJDER, Eric J

“…Coronaviruses can cause respiratory and enteric disease in a wide variety of human and animal hosts. The 2003 outbreak of severe acute respiratory syndrome…”
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Cyclophilin Inhibitors Block Arterivirus Replication by Interfering with Viral RNA Synthesis by de Wilde, Adriaan H, Li, Yanhua, van der Meer, Yvonne, Vuagniaux, Grégoire, Lysek, Robert, Fang, Ying, Snijder, Eric J, van Hemert, Martijn J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Host Factors in Coronavirus Replication by de Wilde, Adriaan H, Snijder, Eric J, Kikkert, Marjolein, van Hemert, Martijn J

“…Coronaviruses are pathogens with a serious impact on human and animal health. They mostly cause enteric or respiratory disease, which can be severe and life…”
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The in Vitro RNA Synthesizing Activity of the Isolated Arterivirus Replication/Transcription Complex Is Dependent on a Host Factor by van Hemert, Martijn J., de Wilde, Adriaan H., Gorbalenya, Alexander E., Snijder, Eric J.

“…The cytoplasmic replication of positive-stranded RNA viruses is associated with characteristic, virus-induced membrane structures that are derived from host…”
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Cyclophilins and cyclophilin inhibitors in nidovirus replication by de Wilde, Adriaan H., Pham, Uyen, Posthuma, Clara C., Snijder, Eric J.

“…Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug…”
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MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment by de Wilde, Adriaan H, Raj, V Stalin, Oudshoorn, Diede, Bestebroer, Theo M, van Nieuwkoop, Stefan, Limpens, Ronald W A L, Posthuma, Clara C, van der Meer, Yvonne, Bárcena, Montserrat, Haagmans, Bart L, Snijder, Eric J, van den Hoogen, Bernadette G

“…Coronavirus (CoV) infections are commonly associated with respiratory and enteric disease in humans and animals. The 2003 outbreak of severe acute respiratory…”
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Immunogenicity and efficacy of one and two doses of Ad26.COV2.S COVID vaccine in adult and aged NHP by Solforosi, Laura, Kuipers, Harmjan, Jongeneelen, Mandy, Rosendahl Huber, Sietske K, van der Lubbe, Joan E M, Dekking, Liesbeth, Czapska-Casey, Dominika N, Izquierdo Gil, Ana, Baert, Miranda R M, Drijver, Joke, Vaneman, Joost, van Huizen, Ella, Choi, Ying, Vreugdenhil, Jessica, Kroos, Sanne, de Wilde, Adriaan H, Kourkouta, Eleni, Custers, Jerome, van der Vlugt, Remko, Veldman, Daniel, Huizingh, Jeroen, Kaszas, Krisztian, Dalebout, Tim J, Myeni, Sebenzile K, Kikkert, Marjolein, Snijder, Eric J, Barouch, Dan H, Böszörményi, Kinga P, Stammes, Marieke A, Kondova, Ivanela, Verschoor, Ernst J, Verstrepen, Babs E, Koopman, Gerrit, Mooij, Petra, Bogers, Willy M J M, van Heerden, Marjolein, Muchene, Leacky, Tolboom, Jeroen T B M, Roozendaal, Ramon, Brandenburg, Boerries, Schuitemaker, Hanneke, Wegmann, Frank, Zahn, Roland C

“…Safe and effective coronavirus disease-19 (COVID-19) vaccines are urgently needed to control the ongoing pandemic. While single-dose vaccine regimens would…”
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Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model by de Wilde, Adriaan H., Falzarano, Darryl, Zevenhoven-Dobbe, Jessika C., Beugeling, Corrine, Fett, Craig, Martellaro, Cynthia, Posthuma, Clara C., Feldmann, Heinz, Perlman, Stanley, Snijder, Eric J.

“…•In cell culture models, low-micromolar doses of alisporivir block SARS-CoV and MERS-CoV replication.•Combination treatment with alisporivir and ribavirin…”
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Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity by Peters, Hannah L., Jochmans, Dirk, de Wilde, Adriaan H., Posthuma, Clara C., Snijder, Eric J., Neyts, Johan, Seley-Radtke, Katherine L.

“…[Display omitted] A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety…”
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A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins by de Wilde, Adriaan H, Wannee, Kazimier F, Scholte, Florine E M, Goeman, Jelle J, Ten Dijke, Peter, Snijder, Eric J, Kikkert, Marjolein, van Hemert, Martijn J

“…To identify host factors relevant for severe acute respiratory syndrome-coronavirus (SARS-CoV) replication, we performed a small interfering RNA (siRNA)…”
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Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture by de Wilde, Adriaan H., Zevenhoven-Dobbe, Jessika C., Beugeling, Corrine, Chatterji, Udayan, de Jong, Danielle, Gallay, Philippe, Szuhai, Karoly, Posthuma, Clara C., Snijder, Eric J.

“…Cyclophilin A (CypA) is an important host factor in the replication of a variety of RNA viruses. Also the replication of several nidoviruses was reported to…”
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Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors by de Wilde, Adriaan H, Boomaars-van der Zanden, A Linda, de Jong, Anja W M, Bárcena, Montserrat, Snijder, Eric J, Posthuma, Clara C

“…Previously, the cyclophilin inhibitors cyclosporine (CsA) and alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including…”
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