Search Results - "de Waal, Robert M. W"

Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease by Wilhelmus, Micha M M, de Waal, Robert M W, Verbeek, Marcel M

“…The pathologic lesions of Alzheimer's disease (AD) are characterized by accumulation of protein aggregates consisting of intracellular or extracellular…”
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Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood‐brain barrier by Biemans, Elisanne A.L.M., Jäkel, Lieke, de Waal, Robert M.W., Kuiperij, H. Bea, Verbeek, Marcel M.

“…Alzheimer's disease and cerebral amyloid angiopathy are characterized by accumulation of amyloid‐β (Aβ) at the cerebrovasculature due to decreased clearance at…”
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Small heat shock proteins induce a cerebral inflammatory reaction by Bruinsma, Ilona B, de Jager, Mieke, Carrano, Anna, Versleijen, Alexandra A M, Veerhuis, Robert, Boelens, Wilbert, Rozemuller, Annemieke J M, de Waal, Robert M W, Verbeek, Marcel M

“…More than 80% of Alzheimer's disease (AD) patients have some degree of cerebral amyloid angiopathy (CAA). In addition to arteries and veins, capillaries can…”
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Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels by Timmer, Nienke M, van Dijk, Laura, der Zee, Catharina E.E.M. van, Kiliaan, Amanda, de Waal, Robert M.W, Verbeek, Marcel M

“…Abstract Enoxaparin (Enox), a low molecular weight heparin, has been shown to lower brain amyloid β (Aβ) load in a mouse model for Alzheimer's disease…”
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Small heat shock proteins inhibit amyloid-β protein aggregation and cerebrovascular amyloid-β protein toxicity by Wilhelmus, Micha M.M., Boelens, Wilbert C., Otte-Höller, Irene, Kamps, Bram, de Waal, Robert M.W., Verbeek, Marcel M.

“…Small heat shock proteins Hsp20 and HspB2/B3 co-localize with Aβ deposition in senile plaques and cerebral amyloid angiopathy in Alzheimer's disease brains,…”
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Functional and Morphologic Analysis of the Fluid-Conducting Meshwork in Xenografted Cutaneous and Primary Uveal Melanoma by Clarijs, Ruud, van Dijk, Marcory, Ruiter, Dirk J, de Waal, Robert M. W

“…In primary uveal and cutaneous melanoma lesions, extracellular matrix (ECM) is often deposited in arcs, loops, and network patterns. Based on prognostic…”
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Metastatic Dormancy Imposed by the Primary Tumor: Does it Exist in Humans? by Peeters, Charlotte F. J. M., de Waal, Robert M. W., Wobbes, Theo, Ruers, Theo J. M.

“…Background In cancer patients, occult micrometastases may become apparent shortly after removal of the primary tumor. Animal experiments have shown that…”
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Outgrowth of human liver metastases after resection of the primary colorectal tumor: A shift in the balance between apoptosis and proliferation by Peeters, Charlotte F.J.M., de Waal, Robert M.W., Wobbes, Theo, Westphal, Johan R., Ruers, Theo J.M.

“…Rapid outgrowth of metastases after removal of the primary tumor has been described in several mouse models. Loss of primary tumor‐induced inhibition of…”
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Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion by Wilhelmus, Micha M.M, Boelens, Wilbert C, Kox, Matthijs, Maat-Schieman, Marion L.C, Veerhuis, Rob, de Waal, Robert M.W, Verbeek, Marcel M

“…Abstract In hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), severe cerebral amyloid angiopathy (CAA) is associated with an…”
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Apolipoprotein E genotype regulates amyloid-beta cytotoxicity by Wilhelmus, Micha M M, Otte-Höller, Irene, Davis, Judianne, Van Nostrand, William E, de Waal, Robert M W, Verbeek, Marcel M

“…The epsilon4 allele of apolipoprotein E (ApoE) is a risk factor for Alzheimer's disease (AD), whereas the epsilon2 allele may be relatively protective. Both…”
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Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators by de Groot-Besseling, Renate R J, Ruers, Theo J M, Lamers-Elemans, Iris L, Maass, Cathy N, de Waal, Robert M W, Westphal, Johan R

“…Upregulation of endogenous angiostatin levels may constitute a novel anti-angiogenic, and therefore anti-tumor therapy. In vitro, angiostatin generation is a…”
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EMAP-II Expression Is Associated with Macrophage Accumulation in Primary Uveal Melanoma by Clarijs, Ruud, Schalkwijk, Lia, Ruiter, Dirk J, de Waal, Robert M. W

“…Primary uveal melanoma may contain arcs, loops, and networks of periodic acid-Schiff (PAS)-positive patterns, along which numerous macrophages are present…”
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Inhibition of α-synuclein aggregation by small heat shock proteins by Bruinsma, Ilona B., Bruggink, Kim A., Kinast, Karsten, Versleijen, Alexandra A. M., Segers-Nolten, Ine M. J., Subramaniam, Vinod, Bea Kuiperij, H., Boelens, Wilbert, de Waal, Robert M. W., Verbeek, Marcel M.

“…The fibrillization of α‐synuclein (α‐syn) is a key event in the pathogenesis of α‐synucleinopathies. Mutant α‐syn (A53T, A30P, or E46K), each linked to…”
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Vessel co-option: how tumors obtain blood supply in the absence of sprouting angiogenesis by Leenders, William P J, Küsters, Benno, de Waal, Robert M W

“…The hypothesis that solid tumors are dependent on angiogenesis, the formation of new vessels, for outgrowth and metastasis has acquired a central position in…”
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Plexin D1 expression is induced on tumor vasculature and tumor cells : A novel target for diagnosis and therapy? by ROODINK, Ilse, RAATS, Jos, VAN DER ZWAAG, Bert, VERRIJP, Kiek, KUSTERS, Benno, VAN BOKHOVEN, Hans, LINKELS, Marianne, DE WAAL, Robert M. W, LEENDERS, William P. J

“…We previously reported that during mouse embryogenesis, plexin D1 (plxnD1) is expressed on neuronal and endothelial cells. Endothelial cells gradually loose…”
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Vascular endothelial growth factor‐A determines detectability of experimental melanoma brain metastasis in GD‐DTPA‐enhanced MRI by Leenders, William, Küsters, Benno, Pikkemaat, Jeroen, Wesseling, Pieter, Ruiter, Dirk, Heerschap, Arend, Barentsz, Jelle, de Waal, Robert MW

“…We have previously shown that the dense vascular network in mouse brain allows for growth of human melanoma xenografts (Mel57) by co‐option of preexisting…”
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Lipoprotein Receptor-Related Protein-1 Mediates Amyloid-β-Mediated Cell Death of Cerebrovascular Cells by Wilhelmus, Micha M.M, Otte-Höller, Irene, van Triel, Jos J.J, Veerhuis, Robert, Maat-Schieman, Marion L.C, Bu, Guojun, de Waal, Robert M.W, Verbeek, Marcel M

“…Inefficient clearance of Aβ, caused by impaired blood-brain barrier crossing into the circulation, seems to be a major cause of Aβ accumulation in the brain of…”
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Sulfation of heparan sulfate associated with amyloid-β plaques in patients with Alzheimer’s disease by Bruinsma, Ilona B., te Riet, Luuk, Gevers, Tom, ten Dam, Gerdy B., van Kuppevelt, Toin H., David, Guido, Küsters, Benno, de Waal, Robert M. W., Verbeek, Marcel M.

“…Alzheimer’s disease (AD) is characterized by pathological lesions such as amyloid-β (Aβ) plaques and cerebral amyloid angiopathy. Both these lesions consist…”
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Progressive loss of endothelial P-selectin expression with increasing malignancy in colorectal cancer by Peeters, Charlotte F J M, Ruers, Theo J M, Westphal, Johan R, de Waal, Robert M W

“…Adhesion of inflammatory cells to vascular endothelium is mediated by specific cell adhesion receptors on both leukocytes and endothelial cells. One of the…”
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Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity by Wilhelmus, Micha M M, Boelens, Wilbert C, Otte-Höller, Irene, Kamps, Bram, Kusters, Benno, Maat-Schieman, Marion L C, de Waal, Robert M W, Verbeek, Marcel M

“…Alzheimer's disease (AD) is characterized by pathological lesions, such as senile plaques (SPs) and cerebral amyloid angiopathy (CAA), both predominantly…”
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