Search Results - "de Waal, Renee"
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Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction
Published in PloS one (28-05-2013)“…Lipoatrophy and/or central fat gain are observed frequently in patients on antiretroviral therapy (ART). Both are assumed to be antiretroviral adverse drug…”
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First-line antiretroviral drug discontinuations in children
Published in PloS one (13-02-2017)“…There are a limited number of paediatric antiretroviral drug options. Characterising the long term safety and durability of different antiretrovirals in…”
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Routine data underestimates the incidence of first-line antiretroviral drug discontinuations due to adverse drug reactions: Observational study in two South African cohorts
Published in PloS one (05-09-2018)“…Estimating the incidence of antiretroviral discontinuations due to adverse drug reactions (ADRs) is important to inform antiretroviral treatment (ART) regimen…”
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HIV drug resistance in sub-Saharan Africa: public health questions and the potential role of real-world data and mathematical modelling
Published in Journal of Virus Eradication (01-11-2018)“…The prevalence of pretreatment resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) is >10% in many low-income countries. As a consequence,…”
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Abacavir safety and effectiveness in young infants with HIV in South African observational cohorts
Published in Antiviral therapy (01-04-2023)“…WHO guidelines recommend abacavir in first-line antiretroviral treatment for children and neonates. However, there is no approved dose <3 months of age, and…”
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Adverse Drug Reactions Causing Admission to Medical Wards: A Cross-Sectional Survey at 4 Hospitals in South Africa
Published in Medicine (Baltimore) (01-05-2016)“…Limited data exist on the burden of serious adverse drug reactions (ADRs) in sub-Saharan Africa, which has high HIV and tuberculosis prevalence. We determined…”
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Determining antenatal medicine exposures in South African women: a comparison of three methods of ascertainment
Published in BMC pregnancy and childbirth (03-06-2022)“…In the absence of clinical trials, data on the safety of medicine exposures in pregnancy are dependent on observational studies conducted after the agent has…”
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Severe antiretroviral-associated skin reactions in South African patients: a case series and case-control analysis
Published in Pharmacoepidemiology and drug safety (01-11-2016)“…Purpose Severe skin reactions may complicate combination antiretroviral therapy (cART). Nevirapine is known to be associated with severe skin reactions, but…”
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Real‐world use and outcomes of dolutegravir‐containing antiretroviral therapy in HIV and tuberculosis co‐infection: a site survey and cohort study in sub‐Saharan Africa
Published in Journal of the International AIDS Society (01-07-2022)“…Introduction Dolutegravir is being scaled up globally as part of antiretroviral therapy (ART), but for people with HIV and tuberculosis co‐infection, its use…”
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Changes in estimated glomerular filtration rate over time in South African HIV‐1‐infected patients receiving tenofovir: a retrospective cohort study
Published in Journal of the International AIDS Society (10-04-2017)“…Introduction: Tenofovir has been associated with decline in kidney function, but in patients with low baseline kidney function, improvements over time have…”
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Changes in estimated glomerular filtration rate over time in South African HIV-1-infected patients receiving tenofovir: a retrospective cohort study
Published in Journal of the International AIDS Society (01-04-2017)“…Introduction: Tenofovir has been associated with decline in kidney function, but in patients with low baseline kidney function, improvements over time have…”
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Serious adverse drug reactions at two children's hospitals in South Africa
Published in BMC pediatrics (04-01-2020)“…The high HIV prevalence in South Africa may potentially be shaping the local adverse drug reaction (ADR) burden. We aimed to describe the prevalence and…”
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Nevirapine Concentrations in Preterm and Low Birth Weight HIV-Exposed Infants: Implications for Dosing Recommendations
Published in The Pediatric infectious disease journal (01-12-2014)“…World Health Organisation guidelines recommend nevirapine 2 mg/kg/d for HIV-exposed infants <2 kg, but 4–6 mg/kg/d for infants >2 kg. In 116 low birth weight…”
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Selection of psychotropic medications for the primary health care essential medicine list : rationale and process
Published in The South African journal of psychiatry (01-09-2018)“…Introduction: Equitable access to essential psychotropic medicines at primary level is fundamental to universal health coverage for mental health. It relies…”
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Metabolic causes of liver disease among adults living with HIV from low‐ and middle‐income countries: a cross‐sectional study
Published in Journal of the International AIDS Society (01-04-2024)“…Introduction Liver disease is a leading cause of morbidity and mortality among persons living with HIV (PLHIV). While chronic viral hepatitis has been…”
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Safety and Effectiveness of Isoniazid Preventive Therapy in Pregnant Women Living with Human Immunodeficiency Virus on Antiretroviral Therapy: An Observational Study Using Linked Population Data
Published in Clinical infectious diseases (05-11-2020)“…Abstract Background Isoniazid preventive therapy (IPT) is widely used to protect against tuberculosis (TB) in people living with human immunodeficiency virus…”
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Preexposure prophylaxis availability among health facilities participating in the global International epidemiology Databases to Evaluate AIDS (IeDEA) consortium
Published in AIDS (London) (01-04-2024)“…Background: While recognized as a key HIV prevention strategy, preexposure prophylaxis (PrEP) availability and accessibility are not well documented globally…”
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Implementing Team Based Learning in an Information Literacy Course
Published in Nordic journal of information literacy in higher education (22-12-2016)“…Introduction: Motivating students to improve their Information Literacy (IL) skills can be a challenge. As a pilot, we implemented Team Based Learning (TBL) in…”
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ART history prior to conception: trends and association with postpartum disengagement from HIV care in Khayelitsha, South Africa (2013–2019): a retrospective cohort study
Published in Journal of the International AIDS Society (01-04-2024)“…Introduction In recent years, the expansion of HIV treatment eligibility has resulted in an increase in people with antiretroviral therapy (ART) experience…”
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