Search Results - "de Vries, Rens M.J.M"

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists by Meijer, Femke A, Doveston, Richard G, de Vries, Rens M.J.M, Vos, Gaël M, Vos, Alex A.A, Leysen, Seppe, Scheepstra, Marcel, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc

“…Retinoic acid receptor-related orphan receptor γt (RORγt) is a nuclear receptor associated with the pathogenesis of autoimmune diseases. Allosteric inhibition…”
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Structure–Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt by Meijer, Femke A, Saris, Annet O.W.M, Doveston, Richard G, Oerlemans, Guido J.M, de Vries, Rens M.J.M, Somsen, Bente A, Unger, Anke, Klebl, Bert, Ottmann, Christian, Cossar, Peter J, Brunsveld, Luc

“…The inhibition of the nuclear receptor retinoic-acid-receptor-related orphan receptor γt (RORγt) is a promising strategy in the treatment of autoimmune…”
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Allosteric small molecule modulators of nuclear receptors by Meijer, Femke A., Leijten-van de Gevel, Iris A., de Vries, Rens M.J.M., Brunsveld, Luc

“…Nuclear Receptors (NRs) are multi-domain proteins, whose natural regulation occurs via ligands for a classical, orthosteric, binding pocket and via intra- and…”
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Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt by de Vries, Rens M. J. M., Meijer, Femke A., Doveston, Richard G., Leijten-van de Gevel, Iris A., Brunsveld, Luc

“…Cooperative ligand binding is an important phenomenon in biological systems where ligand binding influences the binding of another ligand at an alternative…”
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Structural interface between LRRK2 and 14-3-3 protein by Stevers, Loes M, de Vries, Rens M J M, Doveston, Richard G, Milroy, Lech-Gustav, Brunsveld, Luc, Ottmann, Christian

“…Binding of 14-3-3 proteins to leucine-rich repeat protein kinase 2 (LRRK2) is known to be impaired by many Parkinson's disease (PD)-relevant mutations…”
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Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR by Stevers, Loes M., Lam, Chan V., Leysen, Seppe F. R., Meijer, Femke A., van Scheppingen, Daphne S., de Vries, Rens M. J. M., Carlile, Graeme W., Milroy, Lech G., Thomas, David Y., Brunsveld, Luc, Ottmann, Christian

“…Cystic fibrosis is a fatal genetic disease, most frequently caused by the retention of the CFTR (cystic fibrosis transmembrane conductance regulator) mutant…”
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Indazole MRL-871 interacts with PPARγ via a binding mode that induces partial agonism by Leijten-van de Gevel, Iris A., van Herk, Kim H.N., de Vries, Rens M.J.M., Ottenheym, Nicolaas J., Ottmann, Christian, Brunsveld, Luc

“…[Display omitted] The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) plays a central role in metabolic processes. PPARγ full…”
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Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist by Vries, Rens M. J. M., Doveston, Richard G., Meijer, Femke A., Brunsveld, Luc

“…The demand for allosteric targeting of nuclear receptors is high, but examples are limited, and structural information is scarce. The retinoic acid‐related…”
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Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization by Scheepstra, Marcel, Andrei, Sebastian A, de Vries, Rens M. J. M, Meijer, Femke A, Ma, Jian-Nong, Burstein, Ethan S, Olsson, Roger, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc

“…Retinoid X receptors (RXRs) play key roles in many physiological processes in both the periphery and central nervous system. In addition, RXRs form…”
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