Search Results - "de Vries, André H. M."

Practical Aspects of Carbon−Carbon Cross-Coupling Reactions Using Heteroarenes by Slagt, Vincent F, de Vries, André H. M, de Vries, Johannes G, Kellogg, Richard M

“…The use of cross-coupling reactions for the preparation of alkylated and arylated heteroaromatic compounds has increased tremendously over the past two…”
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Influence of Phosphoramidites in Copper-Catalyzed Conjugate Borylation Reaction by Sole, Cristina, Bonet, Amadeu, de Vries, André H. M, de Vries, Johannes G, Lefort, Laurent, Gulyás, Henrik, Fernández, Elena

“…Copper(I) has become the preferred metal to catalyze the β-boration of α,β-unsaturated carbonyl compounds, and now we demonstrate that easily accessible…”
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Catalytic Asymmetric Reduction of a 3,4-Dihydroisoquinoline for the Large-Scale Production of Almorexant: Hydrogenation or Transfer Hydrogenation? by Verzijl, Gerard K. M, de Vries, André H. M, de Vries, Johannes G, Kapitan, Peter, Dax, Thomas, Helms, Matthias, Nazir, Zarghun, Skranc, Wolfgang, Imboden, Christoph, Stichler, Juergen, Ward, Richard A, Abele, Stefan, Lefort, Laurent

“…Several methods are presented for the enantioselective synthesis of the tetrahydroisoquinoline core of almorexant (ACT-078573A), a dual orexin receptor…”
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Cycloruthenated Primary and Secondary Amines as Efficient Catalyst Precursors for Asymmetric Transfer Hydrogenation by Sortais, Jean-Baptiste, Ritleng, Vincent, Voelklin, Adeline, Holuigue, Alexandre, Smail, Hakima, Barloy, Laurent, Sirlin, Claude, Verzijl, Gerard K. M, Boogers, Jeroen A. F, de Vries, André H. M, de Vries, Johannes G, Pfeffer, Michel

“…Ruthenacycles obtained by cyclometalation of enantiopure aromatic primary or secondary amines with [(η6-benzene)RuCl2]2 or with [(η6-p-cymene)RuCl2]2 are…”
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Scalable Synthesis of β‑Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate by Boyer, Serge H, Gonzalez-de-Castro, Angela, Dielemans, J.A. Hubertus, Lefort, Laurent, Zhu, Zuolin, Gnahn, Matthias, Schörghuber, Julia, Steinhofer, Stefan, de Vries, André H. M, Hecker, Scott J

“…We report the scalable, high-yielding, and highly selective synthesis of the β-lactamase inhibitor QPX7728 featuring two key synthetic steps: nickel-catalyzed…”
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Asymmetric Synthesis of a Key Intermediate for Tofacitinib via a Dynamic Kinetic Resolution-Reductive Amination Protocol by Verzijl, Gerard K. M, Schuster, Christian, Dax, Thomas, de Vries, André H. M, Lefort, Laurent

“…We report the first example of a catalytic asymmetric reductive amination under dynamic kinetic resolution (DKR) conditions for the preparation of a chiral…”
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Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation by Verzijl, Gerard K. M, Hassfeld, Jorma, de Vries, André H. M, Lefort, Laurent

“…Herein, we report the first example of the asymmetric hydrogenation of a prochiral benzodiazepine substrate as key transformation in a pilot-scale synthesis of…”
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Rapid Identification of a Scalable Catalyst for the Asymmetric Hydrogenation of a Sterically Demanding Aryl Enamide by Lefort, Laurent, Boogers, Jeroen A. F, Kuilman, Thijs, Vijn, Robert Jan, Janssen, John, Straatman, Harrie, de Vries, Johannes G, de Vries, André H. M

“…High throughput screening was used to find a cost-effective and scalable catalyst for the asymmetric hydrogenation of a sterically demanding enamide as an…”
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Highly Enantioselective Conjugate Additions of Potassium Organotrifluoroborates to Enones by Use of Monodentate Phosphoramidite Ligands by Duursma, Ate, Boiteau, Jean-Guy, Lefort, Laurent, Boogers, Jeroen A. F, de Vries, André H. M, de Vries, Johannes G, Minnaard, Adriaan J, Feringa, Ben L

“…The use of phosphoramidite ligands in the rhodium-catalyzed asymmetric conjugate addition of potassium organotrifluoroborates to various enones in the absence…”
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Homeopathic Ligand-Free Palladium as a Catalyst in the Heck Reaction. A Comparison with a Palladacycle by de Vries, André H. M, Mulders, Jan M. C. A, Mommers, John H. M, Henderickx, Huub J. W, de Vries, Johannes G

“…Ligand-free Pd(OAc)2 can be used as a catalyst in the Heck reaction of aryl bromides as long as the amount of catalyst is kept between 0.01 and 0.1 mol %. At…”
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Screening of a Supramolecular Catalyst Library in the Search for Selective Catalysts for the Asymmetric Hydrogenation of a Difficult Enamide Substrate by Jiang, Xiao-Bin, Lefort, Laurent, Goudriaan, P. Elsbeth, de Vries, André H. M., van Leeuwen, Piet W. N. M., de Vries, Johannes G., Reek, Joost N. H.

“…Bindings for libraries: Large numbers of bidentate ligands have been formed from two monodentate ligands (one based on zinc(II) porphyrin and the other on a…”
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High Enantioselectivity Is Induced by a Single Monodentate Phosphoramidite Ligand in Iridium-Catalyzed Asymmetric Hydrogenation by Giacomina, Francesca, Meetsma, Auke, Panella, Lavinia, Lefort, Laurent, de Vries, André H. M., de Vries, Johannes G.

“…The Full Monty? Stripping a catalyst down to its bare essentials gives a neutral iridium complex containing only one monodentate phosphoramidite ligand that is…”
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Exploiting Noninnocent (E,E)-Dibenzylideneacetone (dba) Effects in Palladium(0)-Mediated Cross-Coupling Reactions: Modulation of the Electronic Properties of dba Affects Catalyst Activity and Stability in Ligand and Ligand-Free Reaction Systems by Fairlamb, Ian J. S., Kapdi, Anant R., Lee, Adam F., McGlacken, Gerard P., Weissburger, Felix, de Vries, André H. M., Schmieder-van de Vondervoort, Lizette

“…The reactivity of palladium(0) complexes, [Pd02(dba‐n,n′‐Z)3] (n,n′‐Z=4,4′‐F; 4,4′‐CF3; 4,4′‐H; 4,4′‐MeO) and [Pd0(dba‐n,n′‐Z)2] (n,n′‐Z=4,4′‐CF3; 4,4′‐H;…”
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Selective Pd-Catalyzed Oxidative Coupling of Anilides with Olefins through C−H Bond Activation at Room Temperature by Boele, Maarten D. K, van Strijdonck, Gino P. F, de Vries, André H. M, Kamer, Paul C. J, de Vries, Johannes G, van Leeuwen, Piet W. N. M

“…Using a high-throughput experimentation approach we found a selective and mild Pd-catalyzed oxidative coupling reaction between anilide derivatives and…”
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Instant Ligand Libraries. Parallel Synthesis of Monodentate Phosphoramidites and in Situ Screening in Asymmetric Hydrogenation by Lefort, Laurent, Boogers, Jeroen A. F, de Vries, André H. M, de Vries, Johannes G

“…Chiral phosphoramidites have been identified as excellent ligands for various metal-catalyzed enantioselective transformations. Taking advantage of their easy…”
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A Mixed-Ligand Approach Enables the Asymmetric Hydrogenation of an α-Isopropylcinnamic Acid en Route to the Renin Inhibitor Aliskiren by Boogers, Jeroen A. F, Felfer, Ulfried, Kotthaus, Martina, Lefort, Laurent, Steinbauer, Gerhard, de Vries, André H. M, de Vries, Johannes G

“…An asymmetric hydrogenation process for the α-isopropyl dihydrocinnamic acid derivative 2, an intermediate for the renin inhibitor aliskiren (4), has been…”
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Asymmetric homogeneous hydrogenations at scale by Ager, David J, de Vries, André H M, de Vries, Johannes G

“…Asymmetric hydrogenations are increasingly being used to introduce stereogenic centres into products used in the life sciences industries. There are a number…”
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Mono- versus Bidentate Ligands in Rhodium-Catalyzed Asymmetric Hydrogenation. A Comparative Rate Study by Peña, Diego, Minnaard, Adriaan J, de Vries, André H. M, de Vries, Johannes G, Feringa, Ben L

“…Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of α- or β-dehydroamino acid derivatives. In…”
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Synthesis of Versatile Building Blocks through Asymmetric Hydrogenation of Functionalized Itaconic Acid Mono-Esters by Hekking, Koen F. W., Lefort, Laurent, de Vries, André H. M., van Delft, Floris L., Schoemaker, Hans E., de Vries, Johannes G., Rutjes, Floris P. J. T.

“…The rhodium‐catalyzed asymmetric hydrogenation of several β‐substituted itaconic acid monoesters, using a library of monodentate phosphoramidite and phosphite…”
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Asymmetric Synthesis of (S)-2-Indolinecarboxylic Acid by Combining Biocatalysis and Homogeneous Catalysis by de Lange, Ben, Hyett, David J., Maas, Peter J. D., Mink, Daniel, van Assema, Friso B. J., Sereinig, Natascha, de Vries, André H. M., de Vries, Johannes G.

“…A tale of two catalysts: (S)‐2‐Indolinecarboxylic acid, an intermediate for ACE inhibitors, was until recently produced by Fischer indole synthesis and…”
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