Search Results - "de Vree, J Marleen L"

Tissue Distribution and Induction of Human Multidrug Resistant Protein 3 by Scheffer, George L, Kool, Marcel, de Haas, Marcel, de Vree, J Marleen L, Pijnenborg, Adriana C L M, Bosman, Diederik K, Oude Elferink, Ronald P J, van der Valk, Paul, Borst, Piet, Scheper, Rik J

“…The multidrug resistance protein (MRP) family consists of several members and, for some of these transporter proteins, distinct roles in multidrug resistance…”
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Mutations in the MDR3 Gene Cause Progressive Familial Intrahepatic Cholestasis by J. Marleen L. De Vree, Jacquemin, Emmanuel, Sturm, Ekkehard, Cresteil, Daniele, Bosma, Piter J., Aten, Jan, Deleuze, Jean-Francois, Desrochers, Marc, Burdelski, Martin, Bernard, Olivier, Ronald P. J. Oude Elferink, Hadchouel, Michelle

“…Class III multidrug resistance (MDR) P-glycoproteins (P-gp), mdr2 in mice and MDR3 in man, mediate the translocation of phosphatidylcholine across the…”
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Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti‐MicroRNA‐122, RG‐101 by Stelma, Femke, van der Ree, Meike H., Sinnige, Marjan J., Brown, Anthony, Swadling, Leo, de Vree, J. Marleen L., Willemse, Sophie B., van der Valk, Marc, Grint, Paul, Neben, Steven, Klenerman, Paul, Barnes, Eleanor, Kootstra, Neeltje A., Reesink, Hendrik W.

“…MicroRNA‐122 is an important host factor for the hepatitis C virus (HCV). Treatment with RG‐101, an N‐acetylgalactosamine‐conjugated anti‐microRNA‐122…”
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Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing by van der Ree, Meike H., Stelma, Femke, Willemse, Sophie B., Brown, Anthony, Swadling, Leo, van der Valk, Marc, Sinnige, Marjan J., van Nuenen, Ad C., de Vree, J. Marleen L., Klenerman, Paul, Barnes, Eleanor, Kootstra, Neeltje A., Reesink, Hendrik W.

“…With the introduction of DAA's, the majority of treated chronic hepatitis C patients (CHC) achieve a viral cure. The exact mechanisms by which the virus is…”
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MRP3, an Organic Anion Transporter Able to Transport Anti-Cancer Drugs by Kool, Marcel, van der Linden, Marcel, de Haas, Marcel, Scheffer, George L., J. Marleen L. De Vree, Smith, Alexander J., Jansen, Gerrit, Peters, Godefridus J., Ponne, Nico, Scheper, Rik J., Ronald P. J. Oude Elferink, Baas, Frank, Borst, Piet

“…The human multidrug-resistance protein (MRP) gene family contains at least six members: MRP1, encoding the multidrug-resistance protein; MRP2 or cMOAT,…”
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The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood by Jacquemin, Emmanuel, De Vree, J. Marleen L., Cresteil, Danièle, Sokal, Etienne M., Sturm, Ekkehard, Dumont, Micheline, Scheffer, George L., Paul, Marianne, Burdelski, Martin, Bosma, Piter J., Bernard, Olivier, Hadchouel, Michelle, Oude Elferink, Ronald P.J.

“…Background & Aims: We have specified the features of progressive familial intrahepatic cholestasis type 3 and investigated in 31 patients whether a defect of…”
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Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis by De Vree, J.Marleen L., Ottenhoff, Roel, Bosma, Piter J., Smith, Alexander J., Aten, Jan, Oude Elferink, Ronald P.J.

“…Background & Aims: Patients with progressive familial intrahepatic cholestasis (PFIC) type 3 have a mutation in the MDR3 gene, encoding the hepatocanalicular…”
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Lack of enteral nutrition during critical illness is associated with profound decrements in biliary lipid concentrations by DE VREE, J. M. L, ROMIJN, J. A, MOK, K. S, MATHUS-VLIEGEN, L. M. H, STOUTENBEEK, C. P, OSTROW, J. D, TYTGAT, G. N. J, SAUERWEIN, H. P, ELFERINK, R. P. J. O, GROEN, A. K

“…Food in the intestine drives the enterohepatic circulation of bile components. We investigated whether parenteral or enteral delivery of nutrients alters serum…”
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A single dose of anti-miR-122, RG-101, in CHC patients results in NK cell normalization with no effect on HCV-specific CD8+ T cell function by Stelma, Femke, van der Ree, Meike H, Sinnige, Marjan J, Brown, Anthony, Swadling, Leo, de Vree, J Marleen L, Willemse, Sophie B, van der Valk, Marc, Grint, Paul, Neben, Steven, Klenerman, Paul, Barnes, Eleanor, Kootstra, Neeltje A, Reesink, Hendrik W

“…MicroRNA-122 (miR-122) is an important host factor for the hepatitis C virus. Treatment with RG-101, a GalNAc conjugated anti-miR-122 oligonucleotide, resulted…”
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Dietary cholesterol does not normalize low plasma cholesterol levels but induces hyperbilirubinemia and hypercholanemia in Mdr2 P-glycoprotein-deficient mice by Voshol, Peter J, Koopen, Nynke R, de Vree, J.Marleen L, Havinga, Rick, Princen, Hans M.G, Oude Elferink, Ronald P.J, Groen, Albert K, Kuipers, Folkert

“…Background/Aims : Mdr2 P-glycoprotein deficiency in mice ( Mdr2 (−/−) ) leads to formation of cholesterol/cholesterol-depleted bile and reduced plasma HDL…”
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Specific detection of multidrug resistance proteins mrp1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies by SCHEFFER, George L, KOOL, Marcel, VAN DER LINDEN, Marcel, DE VREE, J. Marleen L, VAN DER VALK, Paul, ELFERINK, Ronald P. J. Oude, BORST, Piet, SCHEPER, Rik J, HEIJN, Marc, DE HAAS, Marcel, PIJNENBORG, Adriana C. L. M, WIJNHOLDS, Jan, VAN HELVOORT, Ardy, DE JONG, Mariska C, HOOIJBERG, Jan H, MOL, Carla A. A. M

“…Tumor cells may display a multidrug resistance phenotype by overexpression of ATP binding cassette transporter genes such as multidrug resistance (MDR) 1…”
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FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte by Eppens, Elaine F., van Mil, Saskia W.C., de Vree, J.Marleen L., Mok, Kam S., Juijn, Jenneke A., Oude Elferink, Ronald P.J., Berger, Ruud, Houwen, Roderick H.J., Klomp, Leo W.J.

“…Background/Aims : FIC1 (familial intrahepatic cholestasis 1) is affected in two clinically distinct forms of hereditary cholestasis, namely progressive…”
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Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice by SMITH, A. J, DE VREE, J. M. L, OTTENHOFF, R, OUDE ELFERINK, R. P. J, SCHINKEL, A. H, BORST, P

“…Mice homozygous for a disruption in the Mdr2 gene (Mdr2 (-/-) mice) lack the Mdr2 P-glycoprotein (P-gp) in the canalicular membrane of the hepatocyte and are…”
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Lack of enteral nutrition during critical illness is associated with profound decrements in biliary lipid concentrationsrted by the Dutch Organization for Scientific Research, project no. 902-23-097.rted by the Dutch Organization for Scientific Research, project no. 902-23-097.rted by the Dutch Organization for Scientific Research, project no. 902-23-097 by de Vree, J Marleen L, Romijn, Johannes A, Mok, Kam S, Mathus-Vliegen, Lisbeth MH, Stoutenbeek, Chris P, Ostrow, J Donald, Tytgat, Guido NJ, Sauerwein, Hans P, Elferink, Ronald PJ Oude, Groen, Albert K

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Lack of enteral nutrition during critical illness is associated with profound decrements in biliary lipid concentrationsrted by the Dutch Organization for Scientific Research, project no. 902-23-097.rted by the Dutch Organization for Scientific Research, project no. 902-23-097.rted by the Dutch Organization for Scientific Research, project no. 902-23-097.2 by de Vree, J Marleen L, Romijn, Johannes A, Mok, Kam S, Mathus-Vliegen, Lisbeth MH, Stoutenbeek, Chris P, Ostrow, J Donald, Tytgat, Guido NJ, Sauerwein, Hans P, Elferink, Ronald PJ Oude, Groen, Albert K

“…Food in the intestine drives the enterohepatic circulation of bile components. We investigated whether parenteral or enteral delivery of nutrients alters serum…”
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Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis by de Vree, J. Marleen L., Jacquemin, Emmanuel, Sturm, Ekkehard, Cresteil, Danièle, Bosma, Piter J., Aten, Jan, Deleuze, Jean-François, Desrochers, Marc, Burdelski, Martin, Bernard, Olivier, Elferink, Ronald P. J. Oude, Hadchouel, Michelle

“…Class III multidrug resistance (MDR) P-glycoproteins (P-gp), mdr2 in mice and MDR3 in man, mediate the translocation of phosphatidylcholine across the…”
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FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte. Editorial by EPPENS, Elaine F, VAN MIL, Saskia W. C, DE VREE, J. Marleen L, MOK, Kam S, JUIJN, Jenneke A, ELFERINK, Ronald P. J. Oude, BERGER, Ruud, HOUWEN, Roderick H. J, KLOMP, Leo W. J, STIEGER, Bruno

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