Management of Multiple Secreting Paragangliomas in a Succinate Dehydrogenase Subunit D (SDHD) Variant Carrier

Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed...

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Bibliographic Details
Published in:	The Annals of thoracic surgery Vol. 109; no. 2; pp. e87 - e90
Main Authors:	Rijken, Johannes A., de Vos, Berry, Leemans, C. René, Zwezerijnen, G.J.C. Ben, de Graaf, Pim, Hensen, Erik F., Dreijerink, Koen M.A., Dickhoff, Chris, Symersky, Petr
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-02-2020
Subjects:	Adult DNA Mutational Analysis DNA, Neoplasm - genetics Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Humans Magnetic Resonance Imaging Male Mutation Neoplasms, Multiple Primary - diagnosis Neoplasms, Multiple Primary - genetics Neoplasms, Multiple Primary - metabolism Neoplastic Syndromes, Hereditary - diagnosis Neoplastic Syndromes, Hereditary - genetics Neoplastic Syndromes, Hereditary - metabolism Paraganglioma - diagnosis Paraganglioma - genetics Paraganglioma - metabolism Positron Emission Tomography Computed Tomography Succinate Dehydrogenase - genetics Succinate Dehydrogenase - metabolism Thoracic Neoplasms - diagnosis Thoracic Neoplasms - genetics Thoracic Neoplasms - metabolism
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Summary:	Management of functional intrathoracic sympathetic paragangliomas in succinate dehydrogenase subunit D (SDHD) mutation carriers is challenging, and there is no uniform guideline for treatment to date. The risks of potential malignant behavior and long-term cardiovascular morbidity have to be weighed against the risks of treatment complications. We report the multidisciplinary and shared decision-making approach that resulted in successful surgical removal of 3 paragangliomas in a SDHD mutation carrier.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0003-4975 1552-6259
DOI:	10.1016/j.athoracsur.2019.05.037