Search Results - "de Villiers, Sabina"

Increased efficacy of a trivalent nicotine vaccine compared to a dose-matched monovalent vaccine when formulated with alum by de Villiers, Sabina H.L, Cornish, Katherine E, Troska, Andrew J, Pravetoni, Marco, Pentel, Paul R

“…Highlights • A trivalent nicotine vaccine was more immunogenic than monovalent vaccine in rats. • The trivalent vaccine generated higher mean titer and fewer…”
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Nicotine hapten structure, antibody selectivity and effect relationships: Results from a nicotine vaccine screening procedure by de Villiers, Sabina H.L, Lindblom, Nina, Kalayanov, Genadiy, Gordon, Sandra, Baraznenok, Ivan, Malmerfelt, Anna, Marcus, Monica M, Johansson, Anette M, Svensson, Torgny H

“…Abstract The aim of the present study was to synthesise and screen a set of novel nicotine hapten immunogens used for the treatment of nicotine dependence. In…”
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Immunogenicity of individual vaccine components in a bivalent nicotine vaccine differ according to vaccine formulation and administration conditions by Cornish, Katherine E, de Villiers, Sabina H L, Pravetoni, Marco, Pentel, Paul R

“…Structurally distinct nicotine immunogens can elicit independent antibody responses against nicotine when administered concurrently. Co-administering different…”
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Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs by Lindblom, Nina, de Villiers, Sabina H L, Semenova, Svetlana, Kalayanov, Genadiy, Gordon, Sandra, Schilström, Björn, Johansson, Anette M, Markou, Athina, Svensson, Torgny H

“…We recently showed that active immunisation with the nicotine immunoconjugate IP18-KLH reduces the nicotine-induced increase in dopamine (DA) output in the…”
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Active immunization against nicotine alters the distribution of nicotine but not the metabolism to cotinine in the rat by de Villiers, Sabina H L, Lindblom, Nina, Kalayanov, Genadiy, Gordon, Sandra, Johansson, Anette M, Svensson, Torgny H

“…We have previously shown that active immunization with the nicotine immunoconjugate IP18-KLH attenuates the reinforcing effects of nicotine, i.e., suppresses…”
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Negatively Charged Carbon Nanohorn Supported Cationic Liposome Nanoparticles: A Novel Delivery Vehicle for Anti-Nicotine Vaccine by Zheng, Hong, Hu, Yun, Huang, Wei, de Villiers, Sabina, Pentel, Paul, Zhang, Jianfei, Dorn, Harry, Ehrich, Marion, Zhang, Chenming

“…Tobacco addiction is the second-leading cause of death in the world. Due to the nature of nicotine (a small molecule), finding ways to combat nicotine's…”
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Niccine®, a Nicotine Vaccine, for Relapse Prevention: A Phase II, Randomized, Placebo-Controlled, Multicenter Clinical Trial by Tonstad, Serena, Heggen, Eli, Giljam, Hans, Lagerbäck, Per-Åke, Tønnesen, Philip, Wikingsson, Lena Degling, Lindblom, Nina, de Villiers, Sabina, Svensson, Torgny H., Fagerström, Karl-Olov

“…A nicotine vaccine could prevent relapse to smoking by hindering blood nicotine from reaching the brain. Niccine® is a nicotine hapten tetanus-toxoid conjugate…”
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Active Immunization Against Nicotine Dependence by de Villiers, Sabina

“…Tobacco smoking is the largest preventable cause of morbidity and premature mortality in the world. Although its medical consequences are well documented,…”
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Nicotine-induced Fos expression in the nucleus accumbens and the medial prefrontal cortex of the rat: Role of nicotinic and NMDA receptors in the ventral tegmental area by Schilström, Björn, De Villiers, Sabina, Malmerfelt, Anna, Svensson, Torgny H., Nomikos, George G.

“…We have previously shown that the nicotine‐induced dopamine release in the nucleus accumbens can be attenuated by local administration into the ventral…”
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