Search Results - "de Vasconcellos, Jaira F."

Three-Dimensional Modeling of the Structural Microenvironment in Post-Traumatic War Wounds by Christopherson, Gregory T, de Vasconcellos, Jaira F, Dunn, John C, Griffin, Daniel W, Jones, Patrick E, Nesti, Leon J

“…The development of post-traumatic heterotopic ossification (HO) is a common, undesirable sequela in patients with high-energy (war-related) extremity injuries…”
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Computational repositioning and preclinical validation of pentamidine for renal cell cancer by Zerbini, Luiz Fernando, Bhasin, Manoj K, de Vasconcellos, Jaira F, Paccez, Juliano D, Gu, Xuesong, Kung, Andrew L, Libermann, Towia A

“…Although early stages of clear cell renal cell carcinoma (ccRCC) are curable, survival outcome for metastatic ccRCC remains poor. We previously established a…”
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Circulating lymphocytes and monocytes transcriptomic analysis of patients with type 2 diabetes mellitus, dyslipidemia and periodontitis by Corbi, Sâmia C. T., de Vasconcellos, Jaira F., Bastos, Alliny S., Bussaneli, Diego Girotto, da Silva, Bárbara Roque, Santos, Raquel Alves, Takahashi, Catarina S., de S. Rocha, Cristiane, Carvalho, Benilton de Sá, Maurer-Morelli, Cláudia V., Orrico, Silvana R. P., Barros, Silvana P., Scarel-Caminaga, Raquel M.

“…Type 2 diabetes mellitus (T2DM), dyslipidemia and periodontitis are frequently associated pathologies; however, there are no studies showing the peripheral…”
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Tough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells by de Vasconcellos, Jaira F, Byrnes, Colleen, Lee, Y Terry, Allwardt, Joshua M, Kaushal, Megha, Rabel, Antoinette, Miller, Jeffery L

“…In humans, the heterochronic cascade composed of the RNA-binding protein LIN28 and its major target, the let-7 family of microRNAs (miRNAs), is highly…”
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HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts by de Vasconcellos, Jaira F, Lee, Y Terry, Byrnes, Colleen, Tumburu, Laxminath, Rabel, Antoinette, Miller, Jeffery L

“…Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with beta-hemoglobin disorders. Previous studies showed that let-7 microRNAs…”
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Characterization of traumatized muscle-derived multipotent progenitor cells from low-energy trauma by Dingle, Marvin, Fernicola, Stephen D, de Vasconcellos, Jaira F, Zicari, Sonia, Daniels, Christopher, Dunn, John C, Dimtchev, Alexander, Nesti, Leon J

“…Multipotent progenitor cells have been harvested from different human tissues, including the bone marrow, adipose tissue, and umbilical cord blood. Previously,…”
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In vivo model of human post-traumatic heterotopic ossification demonstrates early fibroproliferative signature by de Vasconcellos, Jaira F, Zicari, Sonia, Fernicola, Stephen D, Griffin, Daniel W, Ji, Youngmi, Shin, Emily H, Jones, Patrick, Christopherson, Gregory T, Bharmal, Husain, Cirino, Carl, Nguyen, Thao, Robertson, Astor, Pellegrini, Jr, Vincent D, Nesti, Leon J

“…The relationship between the tissue injury healing response and development of heterotopic ossification (HO) is poorly understood. Here we compare a rat blast…”
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Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts by Lee, Y Terry, de Vasconcellos, Jaira F, Byrnes, Colleen, Kaushal, Megha, Rabel, Antoinette, Tumburu, Laxminath, Allwardt, Joshua M, Miller, Jeffery L

“…Increasing fetal hemoglobin (HbF) levels in adult humans remains an active area in hematologic research. Here we explored erythroid-specific LIN28A expression…”
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LIN28A expression reduces sickling of cultured human erythrocytes by de Vasconcellos, Jaira F, Fasano, Ross M, Lee, Y Terry, Kaushal, Megha, Byrnes, Colleen, Meier, Emily R, Anderson, Molly, Rabel, Antoinette, Braylan, Raul, Stroncek, David F, Miller, Jeffery L

“…Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with sickle cell disease (SCD) and the beta-thalassemias. It was recently reported…”
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A synthetic model of human beta-thalassemia erythropoiesis using CD34+ cells from healthy adult donors by Lee, Y Terry, Kim, Ki Soon, Byrnes, Colleen, de Vasconcellos, Jaira F, Noh, Seung-Jae, Rabel, Antoinette, Meier, Emily R, Miller, Jeffery L

“…Based upon the lack of clinical samples available for research in many laboratories worldwide, a significant gap exists between basic and clinical studies of…”
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Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping by Krivega, Ivan, Byrnes, Colleen, de Vasconcellos, Jaira F., Lee, Y. Terry, Kaushal, Megha, Dean, Ann, Miller, Jeffery L.

“…Induction of fetal hemoglobin (HbF) production in adult erythrocytes can reduce the severity of sickle cell disease and β-thalassemia. Transcription of…”
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A microRNA Signature for Impaired Wound-Healing and Ectopic Bone Formation in Humans by de Vasconcellos, Jaira F., Jackson, Wesley M., Dimtchev, Alexander, Nesti, Leon J.

“…BACKGROUND:Heterotopic ossification (HO) is characterized by the abnormal growth of ectopic bone in soft tissues, frequently occurring within the military…”
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DCUN1D1 and neddylation: Potential targets for cancer therapy by Paccez, Juliano D., Foret, Chiara L.M., de Vasconcellos, Jaira F., Donaldson, Lara, Zerbini, Luiz F.

“…Cancer affects millions of people and understanding the molecular mechanisms related to disease development and progression is essential to manage the disease…”
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LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo by Lee, Y. Terry, de Vasconcellos, Jaira F., Yuan, Joan, Byrnes, Colleen, Noh, Seung-Jae, Meier, Emily R., Kim, Ki Soon, Rabel, Antoinette, Kaushal, Megha, Muljo, Stefan A., Miller, Jeffery L.

“…Reactivation of fetal hemoglobin (HbF) holds therapeutic potential for sickle cell disease and β-thalassemias. In human erythroid cells and hematopoietic…”
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Gene expression profile suggests different mechanisms underlying sporadic and familial mesial temporal lobe epilepsy by Maurer-Morelli, Claudia V, de Vasconcellos, Jaira F, Bruxel, Estela M, Rocha, Cristiane S, do Canto, Amanda M, Tedeschi, Helder, Yasuda, Clarissa L, Cendes, Fernando, Lopes-Cendes, Iscia

“…Most patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) have hippocampal sclerosis on the postoperative histopathological examination…”
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IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts by de Vasconcellos, Jaira F., Tumburu, Laxminath, Byrnes, Colleen, Lee, Y. Terry, Xu, Pauline C., Li, May, Rabel, Antoinette, Clarke, Benjamin A., Guydosh, Nicholas R., Proia, Richard L., Miller, Jeffery L.

“…Here we investigated in primary human erythroid tissues a downstream element of the heterochronic let-7 miRNA pathway, the insulin-like growth factor 2…”
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A Yorkshire swine (Sus scrofa domesticus) model for nerve regeneration and ischemia based on the sciatic nerve and femoral artery by Kinsley, Sarah E., Fernicola, Stephen D., Dingle, Marvin E., Williams, Milfred S., Richardson, Jody M., Taylor, Dennis, de Vasconcellos, Jaira F., Malone, Timothy R., Blattner, Matthew R., Smith, Jonathan K., Oliver, Alli, Koch, Amory L., Riddle, Laura E., Reiter, Cara, Culp, William E., Caterson, Edward J., Nesti, Leon J., Talbot, Simon G.

“…Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve…”
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A comparison between different reference genes for expression studies in human hippocampal tissue by Maurer-Morelli, Claudia V., de Vasconcellos, Jaira F., Reis-Pinto, Fernanda C., Rocha, Cristiane de S., Domingues, Romenia R., Yasuda, Clarissa L., Tedeschi, Helder, De Oliveira, Evandro, Cendes, Fernando, Lopes-Cendes, Iscia

“…The reliability of gene expression studies by mRNA quantification is highly dependent upon several experimental procedures, including the choice of reference…”
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The Let-7 Chronoregulatory Cascade Components May Act Independently to Regulate Fetal Hemoglobin in Human Adult Erythroblasts by de Vasconcellos, Jaira F., Byrnes, Colleen, Lee, Y. Terry, Li, May, Rabel, Antoinette, Proia, Richard L., Miller, Jeffery L.

“…Multiple components of the highly conserved let-7 cascade are developmentally regulated during the fetal-to adult transition of human ontogeny. Previous…”
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Erythroid-Expression of HMGA2 Increases Fetal Hemoglobin in Human Adult Erythroblasts by de Vasconcellos, Jaira F., Lee, Y. Terry, Byrnes, Colleen, Tumburu, Laxminath, Rabel, Antoinette, Miller, Jeffery L.

“…HMGA2 is a member of the high-mobility group A family and plays a role in the regulation of gene transcription and chromatin structure. HMGA2 is a validated…”
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