Search Results - "de Valliere, Cheryl"

The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis by Caratis, Fionä, Opiełka, Mikołaj, Hausmann, Martin, Velasco-Estevez, Maria, Rojek, Bartłomiej, de Vallière, Cheryl, Seuwen, Klaus, Rogler, Gerhard, Karaszewski, Bartosz, Rutkowska, Aleksandra

“…Acidosis is one of the hallmarks of demyelinating central nervous system (CNS) lesions in multiple sclerosis (MS). The response to acidic pH is primarily…”
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OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation by Perren, Leonie, Busch, Moana, Schuler, Cordelia, Ruiz, Pedro A., Foti, Federica, Weibel, Nathalie, de Vallière, Cheryl, Morsy, Yasser, Seuwen, Klaus, Hausmann, Martin, Rogler, Gerhard

“…G-protein-coupled receptors (GPRs), including pro-inflammatory ovarian cancer GPR1 (OGR1/GPR68) and anti-inflammatory T cell death-associated gene 8…”
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pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and Fibrosis by de Vallière, Cheryl, Cosin-Roger, Jesus, Baebler, Katharina, Schoepflin, Anja, Mamie, Céline, Mollet, Michelle, Schuler, Cordelia, Bengs, Susan, Lang, Silvia, Scharl, Michael, Seuwen, Klaus, Ruiz, Pedro A, Hausmann, Martin, Rogler, Gerhard

“…Local extracellular acidification occurs at sites of inflammation. Proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1, also known as GPR68)…”
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The Proton-activated Receptor GPR4 Modulates Intestinal Inflammation by Wang, Yu, de Vallière, Cheryl, Imenez Silva, Pedro H, Leonardi, Irina, Gruber, Sven, Gerstgrasser, Alexandra, Melhem, Hassan, Weber, Achim, Leucht, Katharina, Wolfram, Lutz, Hausmann, Martin, Krieg, Carsten, Thomasson, Koray, Boyman, Onur, Frey-Wagner, Isabelle, Rogler, Gerhard, Wagner, Carsten A

“…During active inflammation, intraluminal intestinal pH is decreased in patients with inflammatory bowel disease [IBD]. Acidic pH may play a role in IBD…”
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The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment by de Vallière, Cheryl, Vidal, Solange, Clay, Ieuan, Jurisic, Giorgia, Tcymbarevich, Irina, Lang, Silvia, Ludwig, Marie-Gabrielle, Okoniewski, Michal, Eloranta, Jyrki J, Kullak-Ublick, Gerd A, Wagner, Carsten A, Rogler, Gerhard, Seuwen, Klaus

“…The pH-sensing receptor ovarian cancer G protein-coupled receptor 1 (OGR1; GPR68) is expressed in the gut. Inflammatory bowel disease is typically associated…”
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Intestinal Activation of pH-Sensing Receptor OGR1 [GPR68] Contributes to Fibrogenesis by Hutter, Senta, van Haaften, Wouter T, Hünerwadel, Anouk, Baebler, Katharina, Herfarth, Neel, Raselli, Tina, Mamie, Céline, Misselwitz, Benjamin, Rogler, Gerhard, Weder, Bruce, Dijkstra, Gerard, Meier, Chantal Florence, de Vallière, Cheryl, Weber, Achim, Imenez Silva, Pedro H, Wagner, Carsten A, Frey-Wagner, Isabelle, Ruiz, Pedro A, Hausmann, Martin

“…pH-sensing ovarian cancer G-protein coupled receptor-1 [OGR1/GPR68] is regulated by key inflammatory cytokines. Patients suffering from inflammatory bowel…”
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Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation by Cosin-Roger, Jesus, Simmen, Simona, Melhem, Hassan, Atrott, Kirstin, Frey-Wagner, Isabelle, Hausmann, Martin, de Vallière, Cheryl, Spalinger, Marianne R., Spielmann, Patrick, Wenger, Roland H., Zeitz, Jonas, Vavricka, Stephan R., Rogler, Gerhard, Ruiz, Pedro A.

“…Hypoxia regulates autophagy and nucleotide-binding oligomerization domain receptor, pyrin domain containing (NLRP)3, two innate immune mechanisms linked by…”
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Deletion of Smad7 Ameliorates Intestinal Inflammation and Contributes to Fibrosis by Schuler, Cordelia, Foti, Federica, Perren, Leonie, Mamie, Céline, Weder, Bruce, Stokmaier, Michelle, de Vallière, Cheryl, Heuchel, Rainer, Ruiz, Pedro A, Rogler, Gerhard, Hausmann, Martin

“…Patients suffering from inflammatory bowel diseases (IBDs) express increased mucosal levels of transforming growth factor (TGF)-β compared with non-IBD…”
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Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model by Maeyashiki, Chiaki, Melhem, Hassan, Hering, Larissa, Baebler, Katharina, Cosin-Roger, Jesus, Schefer, Fabian, Weder, Bruce, Hausmann, Martin, Scharl, Michael, Rogler, Gerhard, de Vallière, Cheryl, Ruiz, Pedro A.

“…Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal inflammation…”
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Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening by Kiessling, Michael K, Schuierer, Sven, Stertz, Silke, Beibel, Martin, Bergling, Sebastian, Knehr, Judith, Carbone, Walter, de Vallière, Cheryl, Tchinda, Joelle, Bouwmeester, Tewis, Seuwen, Klaus, Rogler, Gerhard, Roma, Guglielmo

“…Genome-wide CRISPR-Cas9 dropout screens can identify genes whose knockout affects cell viability. Recent CRISPR screens detected thousands of essential genes…”
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Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease by Tcymbarevich, Irina, Richards, Shola M, Russo, Giancarlo, Kühn-Georgijevic, Jelena, Cosin-Roger, Jesus, Baebler, Katharina, Lang, Silvia, Bengs, Susan, Atrott, Kirstin, Bettoni, Carla, Gruber, Sven, Frey-Wagner, Isabelle, Scharl, Michael, Misselwitz, Benjamin, Wagner, Carsten A, Seuwen, Klaus, Rogler, Gerhard, Ruiz, Pedro A, Spalinger, Marianne, de Vallière, Cheryl

“…Abstract Background Tissue inflammation in inflammatory bowel diseases [IBD] is associated with local acidification. Genetic variants in the pH-sensing G…”
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Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis by Bentz, Susanne, Pesch, Theresa, Wolfram, Lutz, de Vallière, Cheryl, Leucht, Katharina, Fried, Michael, Coy, Johannes F, Hausmann, Martin, Rogler, Gerhard

“…Transketolase-like (TKTL) 1 indirectly replenishes NADPH preventing damage induced by reactive oxygen species (ROS) formed upon intestinal inflammation. We…”
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Role of pH-sensing receptors in colitis by Hausmann, Martin, Seuwen, Klaus, de Vallière, Cheryl, Busch, Moana, Ruiz, Pedro A., Rogler, Gerhard

“…Low pH in the gut is associated with severe inflammation, fibrosis, and colorectal cancer (CRC) and is a hallmark of active inflammatory bowel disease (IBD)…”
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New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4 by Weder, Bruce, Schefer, Fabian, van Haaften, Wouter Tobias, Patsenker, Eleonora, Stickel, Felix, Mueller, Sebastian, Hutter, Senta, Schuler, Cordelia, Baebler, Katharina, Wang, Yu, Mamie, Céline, Dijkstra, Gerard, de Vallière, Cheryl, Imenez Silva, Pedro H, Wagner, Carsten A, Frey-Wagner, Isabelle, Ruiz, Pedro A, Seuwen, Klaus, Rogler, Gerhard, Hausmann, Martin

“…Abstract Background Patients suffering from inflammatory bowel diseases (IBDs) express increased mucosal levels of pH-sensing receptors compared with non-IBD…”
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G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation by de Vallière, Cheryl, Wang, Yu, Eloranta, Jyrki J, Vidal, Solange, Clay, Ieuan, Spalinger, Marianne R, Tcymbarevich, Irina, Terhalle, Anne, Ludwig, Marie-Gabrielle, Suply, Thomas, Fried, Michael, Kullak-Ublick, Gerd A, Frey-Wagner, Isabelle, Scharl, Michael, Seuwen, Klaus, Wagner, Carsten A, Rogler, Gerhard

“…A novel family of proton-sensing G protein-coupled receptors, including OGR1, GPR4, and TDAG8, was identified to be important for physiological pH homeostasis…”
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A Novel OGR1 (GPR68) Inhibitor Attenuates Inflammation in Murine Models of Colitis by de Vallière, Cheryl, Bäbler, Katharina, Busenhart, Philipp, Schwarzfischer, Marlene, Maeyashiki, Chiaki, Schuler, Cordelia, Atrott, Kirstin, Lang, Silvia, Spalinger, Marianne R., Scharl, Michael, Ruiz-Castro, Pedro A., Hausmann, Martin, Rogler, Gerhard

“…Background and Aims: Local extracellular acidification is associated with several conditions, such as ischemia, cancer, metabolic disease, respiratory…”
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The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation by Tcymbarevich, Irina V, Eloranta, Jyrki J, Rossel, Jean-Benoît, Obialo, Nicole, Spalinger, Marianne, Cosin-Roger, Jesus, Lang, Silvia, Kullak-Ublick, Gerd A, Wagner, Carsten A, Scharl, Michael, Seuwen, Klaus, Ruiz, Pedro A, Rogler, Gerhard, de Vallière, Cheryl, Misselwitz, Benjamin

“…Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has…”
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Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68) by de Vallière, Cheryl, Cosin-Roger, Jesus, Simmen, Simona, Atrott, Kirstin, Melhem, Hassan, Zeitz, Jonas, Madanchi, Mehdi, Tcymbarevich, Irina, Fried, Michael, Kullak-Ublick, Gerd A, Vavricka, Stephan R, Misselwitz, Benjamin, Seuwen, Klaus, Wagner, Carsten A, Eloranta, Jyrki J, Rogler, Gerhard, Ruiz, Pedro A

“…Background & Aims A novel family of proton-sensing G-protein–coupled receptors, including ovarian cancer G-protein–coupled receptor 1 (OGR1) (GPR68) has been…”
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Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium by Simmen, Simona, Cosin-Roger, Jesus, Melhem, Hassan, Maliachovas, Nikolaos, Maane, Max, Baebler, Katharina, Weder, Bruce, Maeyashiki, Chiaki, Spanaus, Katharina, Scharl, Michael, de Vallière, Cheryl, Zeitz, Jonas, Vavricka, Stephan R, Hausmann, Martin, Rogler, Gerhard, Ruiz, Pedro A

“…Background & Aims Hypoxia-associated pathways influence the development of inflammatory bowel disease. Adaptive responses to hypoxia are mediated through…”
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82 - Activation of PH-Sensing Receptor OGR1 (GPR68) Induces ER Stress and Autophagy in an Intestinal Epithelial Cell Model by Maeyashiki, Chiaki, Melhem, Hassan, Baebler, Katharina, Lang, Silvia, Scharl, Michael M., Rogler, Gerhard, de Valliere, Cheryl

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