Search Results - "de Stanchina, E."

DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2 by Poirier, J T, Gardner, E E, Connis, N, Moreira, A L, de Stanchina, E, Hann, C L, Rudin, C M

“…Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis, rapid development of resistance to chemotherapy and genetic…”
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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53 by Schmitt, C A, McCurrach, M E, de Stanchina, E, Wallace-Brodeur, R R, Lowe, S W

“…The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor…”
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Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring BRAF by Xing, F, Persaud, Y, Pratilas, C A, Taylor, B S, Janakiraman, M, She, Q-B, Gallardo, H, Liu, C, Merghoub, T, Hefter, B, Dolgalev, I, Viale, A, Heguy, A, De Stanchina, E, Cobrinik, D, Bollag, G, Wolchok, J, Houghton, A, Solit, D B

“…Identifying the spectrum of genetic alterations that cooperate with critical oncogenes to promote transformation provides a foundation for understanding the…”
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Obstruction of BRAFV600E transcription by complementary PNA oligomers as a means to inhibit BRAF-mutant melanoma growth by Rothman, J H, Surriga, O, de Stanchina, E, Vasudeva, S D, Schwartz, G K

“…Peptide nucleic acid (PNA) oligomers are DNA mimics, which are capable of binding gene sequences 1000-fold more avidly than complementary native DNA by strand…”
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Obstruction of BRAF V600E transcription by complementary PNA oligomers as a means to inhibit BRAF-mutant melanoma growth by Rothman, J H, Surriga, O, de Stanchina, E, Vasudeva, S D, Schwartz, G K

“…Peptide nucleic acid (PNA) oligomers are DNA mimics, which are capable of binding gene sequences 1000-fold more avidly than complementary native DNA by strand…”
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p53 tumor suppressor protein regulates the levels of huntingtin gene expression by Feng, Z, Jin, S, Zupnick, A, Hoh, J, de Stanchina, E, Lowe, S, Prives, C, Levine, A J

“…The p53 protein is a transcription factor that integrates various cellular stress signals. The accumulation of the mutant huntingtin protein with an expanded…”
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387 (PB375): Tumor adaptation to PI3K inhibition and its stability increases as a function of time and is overcome by combined inhibiting Bcl2 family proteins by Mukherjee, R., Vanaja, K. Gireesan, Sharma, M., Solomon, H., De Stanchina, E., Chandarlapaty, S., Rosen, N.

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The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase by Sanghvi, Viraj R., Leibold, Josef, Mina, Marco, Mohan, Prathibha, Berishaj, Marjan, Li, Zhuoning, Miele, Matthew M., Lailler, Nathalie, Zhao, Chunying, de Stanchina, Elisa, Viale, Agnes, Akkari, Leila, Lowe, Scott W., Ciriello, Giovanni, Hendrickson, Ronald C., Wendel, Hans-Guido

“…The NRF2 transcription factor controls a cell stress program that is implicated in cancer and there is great interest in targeting NRF2 for therapy. We show…”
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125P LSD1 inhibition restores MHC class I expression and augments the anti-tumor response of immune checkpoint blockade in small cell lung cancer by Sen, T., Nguyen, M.N., Taniguchi, H., Chow, A., De Stanchina, E., Rudin, C.M.

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2233MO CDC7 inhibition constrains lineage plasticity and prevents resistance and neuroendocrine transformation in the lung and prostate by Quintanal-Villalonga, Á., Zaidi, S., Karthaus, W.R., Zhan, Y.A., Shafer, M., Qiu, J., de Stanchina, E., Haffner, M.C., Sawyers, C.L., Rudin, C.M.

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An approach to suppress the evolution of resistance in BRAF(V600E)-mutant cancer by Xue, Y. H., Martelotto, L., Baslan, T., Vides, A., Solomon, M., Mai, T. T., Chaudhary, N., Riely, G. J., Li, B. T., Scott, K., Cechhi, F., Stierner, Ulrika, Chadalavada, K., de Stanchina, E., Schwartz, S., Hembrough, T., Nanjangud, G., Nilsson, Jonas A, Lowe, S. W., Reis, J., Rosen, N., Lito, P.

“…The principles that govern the evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of an…”
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Vepafestinib is effective in preclinical models of sarcomas with RET fusion including a brain metastasis model by Odintsov, I., Liu, A., Khodos, I., Chang, Q., Giuliano, C., Mattar, M., Vojnic, M., Bonifacio, A., De Stanchina, E., Lovati, E., Ladanyi, M., Somwar, R.

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PARP trapping by Talazoparib is a Potent Mechanism of Radiosensitization in Small Cell Lung Cancer Cell Lines and Patient-Derived Xenografts by Laird, J.H., Lok, B.H., Ma, J., Bell, A., De Stanchina, E., Poirier, J., Rudin, C.M.

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Blocking metastatic behavior of MUC16/CA-125-expressing cancer by targeting galectin-3 by Smith, E., Stasenko, M., Rao, T.D., Feit, N.Z., de Stanchina, E., White, T., Weigelt, B., Lorenz, I.C., Spriggs, D.

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy by Lowe, Scott W, Wendel, Hans-Guido, Stanchina, Elisa de, Fridman, Jordan S, Malina, Abba, Ray, Sagarika, Kogan, Scott, Cordon-Cardo, Carlos, Pelletier, Jerry

“…Evading apoptosis is considered to be a hallmark of cancer, because mutations in apoptotic regulators invariably accompany tumorigenesis. Many chemotherapeutic…”
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2MO XPO1 inhibition strongly sensitizes to first-line and second-line therapy in small cell lung cancer by Quintanal-Villalonga, Á., Taniguchi, H., Hao, Y., Chow, A., Zhan, Y.A., Uddin, F., Allaj, V., Manoj, P., Shah, N., Chan, J.M., Offin, M., Ciampricotti, M., Egger, J., Qiu, J., De Stanchina, E., Hollmann, T.J., Koche, R.P., Sen, T., Poirier, J.T., Rudin, C.M.

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1MO Multi-omic characterization of lung tumors identify AKT and EZH2 as potential therapeutic targets in adenocarcinoma-to-squamous transdifferentiation by Quintanal-Villalonga, Á., Taniguchi, H., Zhan, Y.A., Hasan, M.M., Chavan, S.S., Uddin, F., Allaj, V., Manoj, P., Shah, N., Ciampricotti, M., Bhanot, U., Egger, J., Qiu, J., De Stanchina, E., Rekhtman, N., Houck-Loomis, B., Koche, R.P., Yu, H.A., Sen, T., Rudin, C.M.

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1800O Multi-omic characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation by Quintanal-Villalonga, Á., Taniguchi, H., Zhan, Y.A., Hasan, M.M., Chavan, S.S., Uddin, F., Allaj, V., Manoj, P., Shah, N.S., Chan, J.M., Ciampricotti, M., Chow, A., Bhanot, U., Egger, J., Qiu, J., De Stanchina, E., Rekhtman, N., Yu, H.A., Sen, T., Rudin, C.M.

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Obstruction of BRAF.sup.V600E transcription by complementary PNA oligomers as a means to inhibit BRAF-mutant melanoma growth by Rothman, J H, Surriga, O, de Stanchina, E, Vasudeva, S D, Schwartz, G K

“…Peptide nucleic acid (PNA) oligomers are DNA mimics, which are capable of binding gene sequences 1000-fold more avidly than complementary native DNA by strand…”
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Determinants of Exon 7 Splicing in the Spinal Muscular Atrophy Genes, SMN1 and SMN2 by Cartegni, Luca, Hastings, Michelle L., Calarco, John A., de Stanchina, Elisa, Krainer, Adrian R.

“…Spinal muscular atrophy is a neurodegenerative disorder caused by the deletion or mutation of the survival-of-motor-neuron gene, SMN1. An SMN1 paralog, SMN2,…”
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