Search Results - "de Soysa, Yvanka"

Oligogenic inheritance of a human heart disease involving a genetic modifier by Gifford, Casey A, Ranade, Sanjeev S, Samarakoon, Ryan, Salunga, Hazel T, de Soysa, T Yvanka, Huang, Yu, Zhou, Ping, Elfenbein, Aryé, Wyman, Stacia K, Bui, Yen Kim, Cordes Metzler, Kimberly R, Ursell, Philip, Ivey, Kathryn N, Srivastava, Deepak

“…Complex genetic mechanisms are thought to underlie many human diseases, yet experimental proof of this model has been elusive. Here, we show that a human…”
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Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects by de Soysa, T. Yvanka, Ranade, Sanjeev S., Okawa, Satoshi, Ravichandran, Srikanth, Huang, Yu, Salunga, Hazel T., Schricker, Amelia, del Sol, Antonio, Gifford, Casey A., Srivastava, Deepak

“…Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific gene networks results in birth defects, which affect 5% of live…”
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Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain by Marsh, Samuel E., Walker, Alec J., Kamath, Tushar, Dissing-Olesen, Lasse, Hammond, Timothy R., de Soysa, T. Yvanka, Young, Adam M. H., Murphy, Sarah, Abdulraouf, Abdulraouf, Nadaf, Naeem, Dufort, Connor, Walker, Alicia C., Lucca, Liliana E., Kozareva, Velina, Vanderburg, Charles, Hong, Soyon, Bulstrode, Harry, Hutchinson, Peter J., Gaffney, Daniel J., Hafler, David A., Franklin, Robin J. M., Macosko, Evan Z., Stevens, Beth

“…A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues into single-cell suspensions. While many protocols have been…”
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Fetal Deficiency of Lin28 Programs Life‐Long Aberrations in Growth and Glucose Metabolism by Shinoda, Gen, Shyh‐Chang, Ng, Soysa, T. Yvanka de, Zhu, Hao, Seligson, Marc T., Shah, Samar P., Abo‐Sido, Nora, Yabuuchi, Akiko, Hagan, John P., Gregory, Richard I., Asara, John M., Cantley, Lewis C., Moss, Eric G., Daley, George Q.

“…LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over‐expression of Lin28a…”
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Redefining microglia states: Lessons and limits of human and mouse models to study microglia states in neurodegenerative diseases by Yvanka de Soysa, T., Therrien, Martine, Walker, Alicia C., Stevens, Beth

“…Microglia are resident macrophages of the brain parenchyma and play an essential role in various aspects of brain development, plasticity, and homeostasis…”
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Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain by Scott-Hewitt, Nicole, Mahoney, Matthew, Huang, Youtong, Korte, Nils, Yvanka de Soysa, T, Wilton, Daniel K, Knorr, Emily, Mastro, Kevin, Chang, Allison, Zhang, Allison, Melville, David, Schenone, Monica, Hartigan, Christina, Stevens, Beth

“…Neuroimmune interactions mediate intercellular communication and underlie critical brain functions. Microglia, CNS-resident macrophages, modulate the brain…”
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Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism by Shyh-Chang, Ng, Zhu, Hao, Yvanka de Soysa, T., Shinoda, Gen, Seligson, Marc T., Tsanov, Kaloyan M., Nguyen, Liem, Asara, John M., Cantley, Lewis C., Daley, George Q.

“…Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue repair remains unexplained. Lin28a, a highly conserved RNA-binding…”
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Precise let-7 expression levels balance organ regeneration against tumor suppression by Wu, Linwei, Nguyen, Liem H, Zhou, Kejin, de Soysa, T Yvanka, Li, Lin, Miller, Jason B, Tian, Jianmin, Locker, Joseph, Zhang, Shuyuan, Shinoda, Gen, Seligson, Marc T, Zeitels, Lauren R, Acharya, Asha, Wang, Sam C, Mendell, Joshua T, He, Xiaoshun, Nishino, Jinsuke, Morrison, Sean J, Siegwart, Daniel J, Daley, George Q, Shyh-Chang, Ng, Zhu, Hao

“…The in vivo roles for even the most intensely studied microRNAs remain poorly defined. Here, analysis of mouse models revealed that let-7, a large and ancient…”
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Macondo crude oil from the Deepwater Horizon oil spill disrupts specific developmental processes during zebrafish embryogenesis by de Soysa, T Yvanka, Ulrich, Allison, Friedrich, Timo, Pite, Danielle, Compton, Shannon L, Ok, Deborah, Bernardos, Rebecca L, Downes, Gerald B, Hsieh, Shizuka, Stein, Rachael, Lagdameo, M Caterina, Halvorsen, Katherine, Kesich, Lydia-Rose, Barresi, Michael J F

“…The Deepwater Horizon disaster was the largest marine oil spill in history, and total vertical exposure of oil to the water column suggests it could impact an…”
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Lin28a Regulates Germ Cell Pool Size and Fertility by Shinoda, Gen, De Soysa, T. Yvanka, Seligson, Marc T., Yabuuchi, Akiko, Fujiwara, Yuko, Huang, Pei Yi, Hagan, John P., Gregory, Richard I., Moss, Eric G., Daley, George Q.

“…Overexpression of LIN28A is associated with human germ cell tumors and promotes primordial germ cell (PGC) development from embryonic stem cells in vitro and…”
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A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation by Padmanabhan, Arun, de Soysa, T Yvanka, Pelonero, Angelo, Sapp, Valerie, Shah, Parisha P, Wang, Qiaohong, Li, Li, Lee, Clara Youngna, Sadagopan, Nandhini, Nishino, Tomohiro, Ye, Lin, Yang, Rachel, Karnay, Ashley, Poleshko, Andrey, Bolar, Nikhita, Linares-Saldana, Ricardo, Ranade, Sanjeev S, Alexanian, Michael, Morton, Sarah U, Jain, Mohit, Haldar, Saptarsi M, Srivastava, Deepak, Jain, Rajan

“…Human induced pluripotent stem cell (hiPSC) to cardiomyocyte (CM) differentiation has reshaped approaches to studying cardiac development and disease. In this…”
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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

“…Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN . MYCN is itself a target of let-7 , a tumour suppressor family of microRNAs…”
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Embryonic microglia maintain the brain's cortical fault lines by Gupte, Anushree S., de Soysa, T. Yvanka, Stevens, Beth

“…Lawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract…”
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ISSCR Education Committee syllabus and learning guide for enhancing stem cell literacy by Perlin, Julie R., Anderson, William J., Bartfeld, Sina, Couturier, Anna, de Soysa, Yvanka, Hawley, R. Scott, Hu, Ping, Loh, Yuin-Han, Mandal, Lolitika, Master, Zubin, Muotri, Alysson R., Piddini, Eugenia, Polo, Jose M., Mazzoni, Esteban O.

“…The rapidly evolving stem cell field puts much stress on developing educational resources. The ISSCR Education Committee has created a flexible stem cell…”
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Abstract LB-290: Multiple distinct mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Roles, Frederik, Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theissen, Jessica, LaPier, Grace S., Pearson, Dan S., Berthold, Frank, Daley, George Q.

“…Abstract The let-7 microRNA family are known tumor suppressors often deregulated in cancer, yet the underlying mechanisms of let-7 disruption remain poorly…”
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Abstract LB-165: Multiple mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma by Powers, John T., Tsanov, Kaloyan, Roels, Frederik, Spina, Catherine, Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Pearson, Daniel, Theißen, Jessica, Tu, Ho-Chou, LaPier, Grace, Osborne, Jihan, Ross, Samantha, Collins, James, Berthold, Frank, Daley, George

“…Abstract The let-7 microRNA family are known tumor suppressors often deregulated in cancer, yet the underlying mechanisms of let-7 disruption remain poorly…”
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Transcriptional Dynamics of Normal and Hand2-Deficient Cardiogenesis at Single-Cell Resolution by De Soysa, Tarja Yvanka

“…Organogenesis involves integration of myriad cell types, each progressing through successive stages of lineage specification, proliferation and…”
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Abstract 14830: Oligogenic Inheritance of Congenital Heart Disease Involving an Nkx2-5 Modifier by Gifford, Casey, Ranade, Sanjeev, Samarakoon, Ryan, Salunga, Hazel, de Soysa, Yvanka, Huang, Yu, Zhou, Ping, Elfenbein, Arye, Wyman, Stacia, Bui, Yen, Metzler, Kimberly, Ursell, Philip, Ivey, Kathryn, Srivastava, Deepak

“…Complex genetic inheritance is thought to underlie many human diseases, yet experimental proof of this model has been elusive. Here, we show that a human…”
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