Relationship of sarcopenia with bone geometry and mass among postmenopausal women

The aim of this study was to verify whether sarcopenia and its components are associated with hip areal bone mineral density (aBMD) and geometry in postmenopausal women (PW). In this cross-sectional study, appendicular bone-free lean mass (aLM) and hip bone mass and geometry were measured using dual...

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Bibliographic Details
Published in:	Menopause (New York, N.Y.) Vol. 30; no. 1; pp. 63 - 69
Main Authors:	França, Caroline F., Miranda, Camila, Martins, Fernanda M., Pelet, Danyelle C. S., de Souza Lino, Anderson D., Souza, Markus V. C., Orsatti, Fábio L.
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins 01-01-2023
Subjects:	Absorptiometry, Photon Bone Density - physiology Cross-Sectional Studies Female Femur Neck - pathology Humans Postmenopause Sarcopenia - complications
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Summary:	The aim of this study was to verify whether sarcopenia and its components are associated with hip areal bone mineral density (aBMD) and geometry in postmenopausal women (PW). In this cross-sectional study, appendicular bone-free lean mass (aLM) and hip bone mass and geometry were measured using dual-energy x-ray emission absorptiometry (DXA). Muscle power and strength were measured by five times Sit-to-Stand Test (5-STS) and dynamometry, respectively, in 175 PW. Sarcopenia was identified as low aLM plus low muscle strength or low muscle power. Multiple linear regression (covaried by age, smoking, hormonal therapy, and diseases) was used to determine the relationship between sarcopenia and bone geometry and mass. The results are presented as mean differences between groups. Dynamometry, five times Sit-to-Stand Test, and aLM indicated positive associations (P < 0.05) with most indicators of bone mass and geometry. Sarcopenia, applying low muscle strength or low muscle power, was negatively associated with femoral neck width (-0.2 mm, P = 0.001), cortical thickness of femoral calcar (-0.6 mm, P = 0.043), subtrochanteric cortical thickness (-1.2 mm, P = 0.002), femoral neck cross-sectional area (-19.5 mm2, P < 0.001), cross-section moment of inertia (-2,244 mm4, P < 0.001), section modulus (-115 mm3, P < 0.001), femoral neck aBMD (-0.1 g/cm2, P = 0.002), upper femoral neck aBMD (-0.1 g/cm2, P = 0.003), lower femoral neck aBMD (-0.1 g/cm2, P = 0.016), and trochanteric aBMD (-0.1 g/cm2, P = 0.035). Thus, muscle mass, strength and power, alone or in combination (ie, sarcopenia), are associated with low aBMD, impaired bone geometry, and, therefore, bone strength in PW. These measures may help identify PW at risk of hip fractures.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1072-3714 1530-0374
DOI:	10.1097/GME.0000000000002097