Dental panoramic indices and fractal dimension measurements in osteogenesis imperfecta children under pamidronate treatment

Dental panoramic indices and fractal dimension measurements in osteogenesis imperfecta children under pamidronate treatment

To verify radiomorphometric indices and fractal dimension (FD) in dental panoramic radiographs (DPRs) of children with different types of osteogenesis imperfecta (OI) and also to verify the effect of pamidronate (PAM) treatment in such panoramic analyses. In this retrospective study, 197 DPRs of 62...

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Bibliographic Details
Published in:Dento-maxillo-facial radiology Vol. 45; no. 4; p. 20150400
Main Authors: Apolinário, Ana C, Sindeaux, Rafael, de Souza Figueiredo, Paulo T, Guimarães, Ana T B, Acevedo, Ana C, Castro, Luiz C, de Paula, Ana P, de Paula, Lilian M, de Melo, Nilce S, Leite, André F
Format: Journal Article
Language:English
Published: England The British Institute of Radiology 01-01-2016
Subjects:
Adolescent
Bone Density - drug effects
Bone Density Conservation Agents - administration & dosage
Bone Density Conservation Agents - therapeutic use
Bone Resorption - diagnostic imaging
Bone Resorption - drug therapy
Child
Child, Preschool
Dental Arch - diagnostic imaging
Dental Arch - drug effects
Dentistry
Diphosphonates - administration & dosage
Diphosphonates - therapeutic use
Follow-Up Studies
Fractals
Humans
Injections, Intravenous
Mandible - diagnostic imaging
Mandible - drug effects
Osteogenesis Imperfecta - classification
Osteogenesis Imperfecta - diagnostic imaging
Osteogenesis Imperfecta - drug therapy
Radiography, Panoramic - methods
Radiography, Panoramic - statistics & numerical data
Retrospective Studies
Young Adult
panoramic radiography
bone disease
diphosphonate
fractals
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Summary:To verify radiomorphometric indices and fractal dimension (FD) in dental panoramic radiographs (DPRs) of children with different types of osteogenesis imperfecta (OI) and also to verify the effect of pamidronate (PAM) treatment in such panoramic analyses. In this retrospective study, 197 DPRs of 62 children with OI Types I, III and IV who were in treatment with a comparable dosage of intravenous PAM were selected. The mandibular cortical width (MCW), mandibular cortical index, visual estimation of the cortical width and FD of three standardized trabecular and cortical mandibular regions of interest were obtained from the radiographs. Factorial analysis of variance and Fisher test were used to compare FD and MCW measurements in children with different types of OI for different PAM cycles. Children with all types of OI have thinner and more porous mandibular cortices at the beginning of treatment. There were significant differences between MCW and FD of the cortical bone, regarding different types of OI and number of PAM cycles (p = 0.037 and p = 0.044, respectively). FD measurements of the trabecular bone were not statistically different among OI types nor were PAM cycles (p > 0.05). Children with OI presented cortical bone alterations after PAM treatment. Both MCW and the FD of the cortical bone were higher in children with OI after PAM treatment. It is argued that cortical bone should be considered for analyzing patients with OI, as well as to monitor the progress of PAM treatment.
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ISSN:0250-832X
1476-542X
DOI:10.1259/dmfr.20150400