Resistance training may concomitantly benefit body composition, blood pressure and muscle MMP-2 activity on the left ventricle of high-fat fed diet rats

Abstract Objective The purpose of this study was to evaluate the effect of resistance training (RT) on body composition, systolic and diastolic blood pressures (BP), and activity of muscle MMP-2 in the left ventricle of high-fat fed rats. Materials/Methods We have evaluated 32 male Wistar rats divid...

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Published in:	Metabolism, clinical and experimental Vol. 62; no. 10; pp. 1477 - 1484
Main Authors:	Leite, Richard Diego, Durigan, Rita de Cássia Marqueti, de Souza Lino, Anderson Diogo, de Souza Campos, Markus Vinicius, Souza, Maria das Graças, Selistre-de-Araújo, Heloisa Silvestre, Bouskela, Eliete, Kraemer-Aguiar, Luiz Guilherme
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-10-2013 Elsevier
Subjects:	Animals Biological and medical sciences Blood Pressure - physiology Body Composition - physiology Diet, High-Fat - methods Endocrinology & Metabolism Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Heart Ventricles - metabolism Heart Ventricles - physiopathology Left ventricle Male Matrix metallopeptidase Matrix Metalloproteinase 2 - metabolism Muscles - metabolism Muscles - physiopathology Obesity Obesity - metabolism Obesity - physiopathology Physical Conditioning, Animal Rats Rats, Wistar Resistance training Resistance Training - methods Vertebrates: anatomy and physiology, studies on body, several organs or systems SED-OB Resistance training group RT Resistance training obese group Matrix metallopeptidase Metalloproteinases BP Left ventricle mass to body mass ratio RT-OB Heart mass to body mass ratio Resistance training Sedentary group Extracellular matrix Tumour necrosis factor-alfa Blood pressure LV:FFM Carrying load Obesity MMPs CL LV:BM ECM Left ventricle Metalloproteinase-2 CV SED MMP-2 TNF-α Cardiovascular risk HM:BM Left ventricle mass to fat free mass Sedentary obese group Rat Rodentia Activity Body composition Feeding Resistance Vertebrata Mammalia Diet Animal Fat Arterial pressure Muscle Hemodynamics Endocrinology
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Summary:	Abstract Objective The purpose of this study was to evaluate the effect of resistance training (RT) on body composition, systolic and diastolic blood pressures (BP), and activity of muscle MMP-2 in the left ventricle of high-fat fed rats. Materials/Methods We have evaluated 32 male Wistar rats divided into four experimental groups (n = 8/each) according to diet and exercise status: sedentary (SED; standard diet), sedentary obese (SED-OB; diet: 30% of fat), RT (RT; standard diet) and RT obese (RT-OB; diet: 30% of fat). After weaning (day 21), animals were subjected to the experimental diet according to their groups during 24 weeks. A 12-week strength-training period was used, during which the rats climbed a 1.1-m vertical ladder with weights attached to their tails. Sessions were performed three times/week (Mondays, Wednesdays and Fridays), with 4–9 climbs/session and 8–12 dynamic movements/climb. Results RT induced higher muscle MMP-2 activity in the left ventricle in RT and RT-OB groups. Moreover, this study demonstrated that RT promoted lower body and fat masses, fat percentage, systolic and diastolic BPs and higher fat free mass in both trained groups. Conclusion RT increased muscle MMP-2 activity in the left ventricle, induced positive changes on body composition and lowered BPs in high-fat diet fed rats, suggesting that it may be a useful tool to prevent alterations induced by high-fat diet consumption.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0026-0495 1532-8600
DOI:	10.1016/j.metabol.2013.05.009